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Pharmacological options for the protection of ovarian function in patients undergoing chemotherapy

dc.contributor.authorBotha, Matthys Hennieen_ZA
dc.date.accessioned2016-12-06T07:49:08Z
dc.date.available2016-12-06T07:49:08Z
dc.date.issued2015
dc.identifier.citationBotha, M. H. 2015. Pharmacological options for the protection of ovarian function in patients undergoing chemotherapy. Southern African Journal of Gynaecological Oncology, 7(1):27-33.
dc.identifier.issn2220-105X (online)
dc.identifier.issn2074-2835 (print)
dc.identifier.urihttp://hdl.handle.net/10019.1/99935
dc.descriptionCITATION: Botha, M. H. 2015. Pharmacological options for the protection of ovarian function in patients undergoing chemotherapy. Southern African Journal of Gynaecological Oncology, 7(1):27-33.
dc.descriptionThe original publication is available at http://www.sajgo.co.za
dc.description.abstractChemotherapy, particularly alkylating agents, can be toxic to germ cells, and may lead to treatment amenorrhoea in young women. The age at which chemotherapy is administered is a strong predictor of subsequent premature ovarian failure, with older patients being at the highest risk. Smaller primordial follicles may survive the insult of chemotherapy better, and the suppression of follicle development may protect the germ cell pool. The suppression of follicle development by gonadotrophin-releasing hormone agonists (or antagonists) or combined oral contraceptives has been reported in the literature. The results are promising, but conflicting reports on the protection makes further studies essential.en_ZA
dc.description.urihttp://www.sajgo.co.za/index.php/sajgo/article/view/185
dc.format.extent7 pagesen_ZA
dc.language.isoen_ZAen_ZA
dc.publisherMedpharm Publicationsen_ZA
dc.subjectChemotherapyen_ZA
dc.subjectOvarian functionen_ZA
dc.subjectPremature ovarian failureen_ZA
dc.subjectRadiotherapyen_ZA
dc.subjectPharmacologyen_ZA
dc.titlePharmacological options for the protection of ovarian function in patients undergoing chemotherapyen_ZA
dc.typeArticleen_ZA
dc.description.versionPublisher's version
dc.rights.holderSouth African Society of Gynaecologic Oncologyen_ZA


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