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Meeting the challenges in the diagnosis of inflammatory myopathies

dc.contributor.authorManie, Mouroeden_ZA
dc.date.accessioned2016-08-01T11:48:35Z
dc.date.available2016-08-01T11:48:35Z
dc.date.issued2015
dc.identifier.citationManie, M. 2015. Meeting the challenges in the diagnosis of inflammatory myopathies. South African Medical Journal, 105(12):1076, doi:10.7196/SAMJ.2015.v105i12.10226
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.otherdoi:10.7196/SAMJ.2015.v105i12.10226
dc.identifier.urihttp://hdl.handle.net/10019.1/99290
dc.descriptionCITATION: Manie, M. 2015. Meeting the challenges in the diagnosis of inflammatory myopathies. South African Medical Journal, 105(12):1076, doi:10.7196/SAMJ.2015.v105i12.10226.
dc.descriptionThe original publication is available at http://www.samj.org.za
dc.description.abstractInflammatory myopathy (IM) is a rubric term to describe a heterogeneous group of muscle diseases typified by dermatomyositis and polymyositis. The current classifications are unsatisfactory, but IM associated with other connective tissue diseases (CTDs), such as systemic lupus erythematosus, underlying malignancy and HIV, should also be included. Although uncommon, IM should always be considered in a patient who presents with proximal weakness of gradual onset and has raised serum muscle enzymes. The diagnosis may be obvious if the patient has diagnostic skin signs such as heliotropic rash (peri-orbital discoloration) and Gottron’s lesions (typically on the extensor surfaces of the fingers). In the absence of obvious skin manifestations, other features of a CTD such as Raynaud’s phenomenon, abnormal capilloroscopy and the presence of serum antinuclear factor antibody should be searched for. Conditions that mimic IM include other causes of myopathy such as endocrine disorders, adverse effects of medication, metabolic myopathies and muscle dystrophies. Atypical features suggesting an alternative diagnosis are acute onset, severe pain, assymmetrical involvement, distal weakness and wasting. Appropriate investigations include a chest radiograph indicating interstitial lung disease or malignancy. Electromyography and muscle biopsy are useful in cases where other diagnoses are suspected.en_ZA
dc.description.abstractAFRIKAANSE OPSOMMING: Geen opsomming beskikbaaraf_ZA
dc.description.urihttp://www.samj.org.za/index.php/samj/article/view/10226
dc.format.extent3 pages : illustrationsen_ZA
dc.language.isoen_ZAen_ZA
dc.publisherHealth & Medical Publishing Groupen_ZA
dc.subjectMuscles -- Diseasesen_ZA
dc.subjectDermatomyositis -- Diagnosisen_ZA
dc.subjectPolymyositis -- Diagnosisen_ZA
dc.titleMeeting the challenges in the diagnosis of inflammatory myopathiesen_ZA
dc.typeArticleen_ZA
dc.description.versionPublisher's version
dc.rights.holderHealth & Medical Publishing Groupen_ZA


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