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A comparison of elasticities of viral levels to specific immune response mechanisms in human immunodeficiency virus infection

dc.contributor.authorShowa, Sarudzai P.en_ZA
dc.contributor.authorNyabadza, Faraien_ZA
dc.contributor.authorHove-Musekwa, Senelani D.en_ZA
dc.contributor.authorMagombedze, Geshamen_ZA
dc.date.accessioned2015-07-23T14:27:55Z
dc.date.available2015-07-23T14:27:55Z
dc.date.issued2014-10
dc.identifier.citationShowa, S. P., Nyabadza, F., Hove-Musekwa, S. D. & Magombedze, G. 2014. A comparison of elasticities of viral levels to specific immune response mechanisms in human immunodeficiency virus infection. BMC Research Notes, 7(1):737, doi:10.1186/1756-0500-7-737.en_ZA
dc.identifier.issn1756-0500 (online)
dc.identifier.otherdoi:10.1186/1756-0500-7-737
dc.identifier.urihttp://hdl.handle.net/10019.1/97253
dc.descriptionCITATION: Showa, S. P., Nyabadza, F., Hove-Musekwa, S. D. & Magombedze, G. 2014. A comparison of elasticities of viral levels to specific immune response mechanisms in human immunodeficiency virus infection. BMC Research Notes, 7(1):737, doi:10.1186/1756-0500-7-737.en_ZA
dc.descriptionThe original publication is available at http://www.biomedcentral.com/1756-0500/7/737en_ZA
dc.description.abstractBackground The presence of an asymptomatic phase in an HIV infection indicates that the immune system can partially control the infection. Determining the immune mechanisms that contribute significantly to the partial control of the infection enhance the HIV infection intervention strategies and is important in vaccine development. Towards this goal, a discrete time HIV model, which incorporates the life cycle aspects of the virus, the antibody (humoral) response and the cell-mediated immune response is formulated to determine immune system components that are most efficient in controlling viral levels. Ecological relationships are used to model the interplay between the immune system components and the HIV pathogen. Model simulations and transient elasticity analysis of the viral levels to immune response parameters are used to compare the different immune mechanisms. Results It is shown that cell-mediated immune response is more effective in controlling the viral levels than the antibody response. Killing of infected cells is shown to be crucial in controlling the viral levels. Our results show a negative correlation between the antibody response and the viral levels in the early stages of the infection, but we predicted this immune mechanism to be positively correlated with the viral levels in the late stage of the infection. A result that suggests lack of relevance of antibody response with infection progression. On the contrary, we predicted the cell-mediated immune response to be always negatively correlated with viral levels. Conclusion Neutralizing antibodies can only control the viral levels in the early days of the HIV infection whereas cell-mediated immune response is beneficial during all the stages of the infection. This study predicts that vaccine design efforts should also focus on stimulating killer T cells that target infected cells.en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherBioMed Centralen_ZA
dc.subjectImmune response -- Mathematical modelsen_ZA
dc.subjectHIV infections -- Immunological aspectsen_ZA
dc.subjectCellular immunityen_ZA
dc.subjectViral levels -- Elasticityen_ZA
dc.titleA comparison of elasticities of viral levels to specific immune response mechanisms in human immunodeficiency virus infectionen_ZA
dc.typeArticleen_ZA
dc.date.updated2014-11-04T00:03:36Z
dc.description.versionPublishers’ versionen_ZA
dc.rights.holderSarudzai P Showa et al.; licensee BioMed Central Ltd.en_ZA


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