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Comparison of cross-sectional HIV incidence assay results from dried blood spots and plasma
(Public Library of Science, 2017-02-23)
Background:
Assays have been developed for cross-sectional HIV incidence estimation using plasma samples. Large scale surveillance programs are planned using dried blood spot (DBS) specimens for incidence assessment. ...
Strengthening HIV surveillance in the antiretroviral therapy era : rationale and design of a longitudinal study to monitor HIV prevalence and incidence in the uMgungundlovu District, KwaZulu-Natal, South Africa
(BioMed Central, 2015)
Background:
South Africa has over 6,000,000 HIV infected individuals and the province of KwaZulu-Natal (KZN) is
the most severely affected. As public health initiatives to better control the HIV epidemic are implemented, ...
Recalibration of the limiting antigen avidity EIA to determine mean duration of recent infection in divergent HIV-1 subtypes
(Public Library of Science, 2015)
Background:
Mean duration of recent infection (MDRI) and misclassification of long-term HIV-1 infections, as proportion false recent (PFR), are critical parameters for laboratory-based assays for estimating HIV-1 ...
Incidence of TB and HIV in prospectively followed household contacts of TB index patients in South Africa
(PLoS, 2014-04)
Objective: To report the incidence rates of TB and HIV in household contacts of index patients diagnosed with TB.
Design: A prospective cohort study in the Matlosana sub-district of North West Province, South Africa.
Methods: ...
Evaluating audio computer assisted self-interviews in urban south African communities : evidence for good suitability and reduced social desirability bias of a cross-sectional survey on sexual behaviour
(BioMed Central, 2013-01)
Abstract: Efficient HIV prevention requires accurate identification of individuals with risky sexual behaviour. However, self-reported data from sexual behaviour surveys are prone to social desirability bias (SDB). Audio ...
Cost-effectiveness of Xpert MTB/RIF and investing in health care in Africa
(Elsevier, 2014-10)
The Xpert MTB/RIF assay is an accurate test for the diagnosis of tuberculosis when an adequate sputum sample can be obtained; even in smear-negative tuberculosis the sensitivity is about 67%.1, 2 Although the assay turnaround ...
A comparison of biomarker based incidence estimators
(Public Library of Science (PLOS), 2009-10)
Background: Cross-sectional surveys utilizing biomarkers that test for recent infection provide a convenient and cost effective way to estimate HIV incidence. In particular, the BED assay has been developed for this purpose. ...
Seroconverting blood donors as a resource for characterising and optimising recent infection testing algorithms for incidence estimation
(Public Library of Science, 2011-06-09)
Introduction: Biomarker-based cross-sectional incidence estimation requires a Recent Infection Testing Algorithm (RITA) with an adequately large mean recency duration, to achieve reasonable survey counts, and a low ...
HIV treatment as prevention : principles of good HIV epidemiology modelling for public health decision- making in all modes of prevention and evaluation
(Public Library of Science (PLOS), 2012-07)
Public health responses to HIV epidemics have
long relied on epidemiological modelling analyses to help
prospectively project and retrospectively estimate the
impact, cost-effectiveness, affordability, and investment
returns ...
Cost-effectiveness of different strategies to monitor adults on antiretroviral treatment : a combined analysis of three mathematical models
(Elsevier, 2014-01)
Background
WHO's 2013 revisions to its Consolidated Guidelines on antiretroviral drugs recommend routine viral load monitoring, rather than clinical or immunological monitoring, as the preferred monitoring approach on the ...