Browsing South African Centre for Epidemiological Modelling and Analysis (SACEMA) by Title
Now showing items 1-20 of 129
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Accounting for regional transmission variability and the impact of malaria control interventions in Ghana : a population level mathematical modelling approach
(BMC (part of Springer Nature), 2020-11-23)Background: This paper investigates the impact of malaria preventive interventions in Ghana and the prospects of achieving programme goals using mathematical models based on regionally diverse climatic zones of the ... -
African voices and leadership is imperative for the global AIDS response
(Pan African Medical Journal, 2019-02-22)This position paper is written in reference to the recent extensive media coverage of the report of the Independent Panel describing Harassment, Including Sexual Harassment, Bullying and Abuse of Power at UNAIDS Secretariat ... -
Age differences between sexual partners, behavioural and demographic correlates, and HIV infection on Likoma Island, Malawi
(Springer Nature, 2016)Patterns of age differences between sexual partners – age-mixing – may partially explain the magnitude of HIV epidemics in Sub-Saharan Africa. However, evidence of age-disparity as a risk factor for HIV remains mixed. We ... -
Antiretroviral therapy for prevention of tuberculosis in adults with HIV : a systematic review and Meta-Analysis
(Public Library of Science, 2012-07)Background: Human immunodeficiency virus (HIV) infection is the strongest risk factor for developing tuberculosis and has fuelled its resurgence, especially in sub-Saharan Africa. In 2010, there were an estimated 1.1 ... -
Are HIV and reproductive health services adapted to the needs of female sex workers? results of a policy and situational analysis in Tete, Mozambique
(BioMed Central, 2016)Background In the context of an implementation research project aiming at improving use of HIV and sexual and reproductive health (SRH) services for female sex workers (FSWs), a broad situational analysis was conducted ... -
Artificial warthog burrows used to sample adult and immature tsetse (Glossina spp) in the Zambezi Valley of Zimbabwe
(PLoS, 2015-03)Background: The biology of adult tsetse (Glossina spp), vectors of trypanosomiasis in Africa, has been extensively studied – but little is known about larviposition in the field. Methodology/Principal Findings: In ... -
The association between timing of initiation of antenatal care and stillbirths : a retrospective cohort study of pregnant women in Cape Town, South Africa
(BioMed Central, 2014-06-13)Background There is renewed interest in stillbirth prevention for lower-middle income countries. Early initiation of and properly timed antenatal care (ANC) is thought to reduce the risk of many adverse birth outcomes. ... -
Barriers to HIV and sexual and reproductive health care for female sex workers in Tete, Mozambique : results from a cross-sectional survey and focus group discussions
(BioMed Central, 2016)Background: In the context of an operational research project in Tete, Mozambique, use of, and barriers to, HIV and sexual and reproductive health (HIV/SRH) commodities and services for female sex workers (FSWs) were assessed ... -
BED estimates of HIV incidence : resolving the differences, making things simpler
(PLOS, 2012-01)Objective: Develop a simple method for optimal estimation of HIV incidence using the BED capture enzyme immunoassay. Design: Use existing BED data to estimate mean recency duration, false recency rates and HIV incidence ... -
Beyond risk compensation : clusters of antiretroviral treatment (ART) users in sexual networks can modify the impact of ART on HIV incidence
(Public Library of Science, 2016)Introduction: Concerns about risk compensation—increased risk behaviours in response to a perception of reduced HIV transmission risk—after the initiation of ART have largely been dispelled in empirical studies, but ... -
Birth outcomes following antiretroviral exposure during pregnancy : initial results from a pregnancy exposure registry in South Africa
(AOSIS, 2019)Background: In 2013, a pregnancy exposure registry and birth defects surveillance (PER/BDS) system was initiated in eThekwini District, KwaZulu-Natal (KZN), to assess the impact of antiretroviral treatment (ART) on birth ... -
Burden of new and recurrent tuberculosis in a major South African city stratified by age and HIV-status
(Public Library of Science, 2011-10-10)Aim To describe the burden of tuberculosis (TB) in Cape Town by calculating TB incidence rates stratified by age and HIV-status, assessing the contribution of retreatment disease and estimating the cumulative lifetime TB ... -
Climate change and African trypanosomiasis vector populations in Zimbabwe’s Zambezi Valley : a mathematical modelling study
(Public Library of Science, 2018)Background: Quantifying the effects of climate change on the entomological and epidemiological components of vector-borne diseases is an essential part of climate change research, but evidence for such effects remains ... -
Clinical prognostic value of RNA viral load and CD4 cell counts during untreated HIV-1 infection : a quantitative review
(Public Library of Science, 2009-16-07)Background: The prognostic value of CD4 counts and RNA viral load for identifying treatment need in HIV-infected individuals depends on (a) variation within and among individuals, and (b) relative risks of clinical progression ... -
A comparison of biomarker based incidence estimators
(Public Library of Science (PLOS), 2009-10)Background: Cross-sectional surveys utilizing biomarkers that test for recent infection provide a convenient and cost effective way to estimate HIV incidence. In particular, the BED assay has been developed for this purpose. ... -
Comparison of cross-sectional HIV incidence assay results from dried blood spots and plasma
(Public Library of Science, 2017-02-23)Background: Assays have been developed for cross-sectional HIV incidence estimation using plasma samples. Large scale surveillance programs are planned using dried blood spot (DBS) specimens for incidence assessment. ... -
A comparison of self-report and antiretroviral detection to inform estimates of antiretroviral therapy coverage, viral load suppression and HIV incidence in Kwazulu-Natal, South Africa
(BioMed Central, 2017-09-29)Abstract Background Accurately identifying individuals who are on antiretroviral therapy (ART) is important to determine ART coverage and proportion on ART who are virally ... -
Complete genome sequence of dengue virus serotype 2, Asian/American genotype, isolated from the urine of a Venezuelan child with hemorrhagic fever in 2016
(American Society for Microbiology, 2018)The complete genome sequence was obtained for a Dengue virus 2 isolate from the urine of an 8-year-old girl who was hospitalized with dengue hemorrhagic fever in 2016 in Venezuela. -
Complete genome sequences of identical zika virus isolates in a nursing mother and her infant
(American Society for Microbiology, 2017)ENGLISH ABSTRACT: Complete genome sequences were obtained for Zika viruses isolated from the breast milk of a Venezuelan patient and her child, who was exclusively breastfeeding at the time. These sequences are the first ... -
Computational analysis of antibody dynamics identifies recent HIV-1 infection
(American Society for Clinical Investigation, 2018)Accurate HIV-1 incidence estimation is critical to the success of HIV-1 prevention strategies. Current assays are limited by high false recent rates (FRRs) in certain populations and a short mean duration of recent infection ...
