Subject
Now showing items 1-7 of 7
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BED estimates of HIV incidence : resolving the differences, making things simpler
(PLOS, 2012-01)Objective: Develop a simple method for optimal estimation of HIV incidence using the BED capture enzyme immunoassay. Design: Use existing BED data to estimate mean recency duration, false recency rates and HIV incidence ... -
Clinical prognostic value of RNA viral load and CD4 cell counts during untreated HIV-1 infection : a quantitative review
(Public Library of Science, 2009-16-07)Background: The prognostic value of CD4 counts and RNA viral load for identifying treatment need in HIV-infected individuals depends on (a) variation within and among individuals, and (b) relative risks of clinical progression ... -
A general HIV incidence inference scheme based on likelihood of individual level data and a population renewal equation
(PLOS, 2012-09-12)We derive a new method to estimate the age specific incidence of an infection with a differential mortality, using individual level infection status data from successive surveys. The method consists of a) an SI-type model ... -
How should we best estimate the mean recency duration for the BED method?
(PLOS, 2012-11-16)BED estimates of HIV incidence from cross-sectional surveys are obtained by restricting, to fixed time T, the period over which incidence is estimated. The appropriate mean recency duration (VT) then refers to the time ... -
A model of HIV infection with two viral strains and cytotoxic T-lymphocyte response under structured treatment interruptions
(Academy of Science of South Africa, 2008)We develop a model of HIV infection with two viral strains, a cytotoxic T-lymphocyte (CTL) response and structured treatment interruptions. We derive new analytical relations characterizing the dynamics between drug-sensitive ... -
Screening for HIV-associated tuberculosis and rifampicin resistance before antiretroviral therapy using the Xpert MTB/RIF assay : a prospective study
(Public Library of Science, 2011-07-26)Background: The World Health Organization has endorsed the Xpert MTB/RIF assay for investigation of patients suspected of having tuberculosis (TB). However, its utility for routine TB screening and detection of rifampicin ... -
Statistical power and estimation of incidence rate ratios obtained from BED incidence testing for evaluating HIV interventions among young people
(Public Library of Science, 2011-08-10)Background: The objectives of this study were to determine the capacity of BED incidence testing to a) estimate the effect of a HIV prevention intervention and b) provide adequate statistical power, when used among young ...
