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Understanding interventions for improving routine immunization coverage in children in low- and middle-income countries : a systematic review protocol

dc.contributor.authorMachingaidze, Shingaien_ZA
dc.contributor.authorRehfuess, Evaen_ZA
dc.contributor.authorVon Kries, Rudigeren_ZA
dc.contributor.authorHussey, Gregory D.en_ZA
dc.contributor.authorWiysonge, Charles S.en_ZA
dc.date.accessioned2014-09-17T08:14:24Z
dc.date.available2014-09-17T08:14:24Z
dc.date.issued2013-11
dc.identifier.citationMachingaidze, S. et al. 2013. Understanding interventions for improving routine immunization coverage in children in low- and middle-income countries: a systematic review protocol. Systematic Reviews, 2(1):106, doi:10.1186/2046-4053-2-106.en_ZA
dc.identifier.issn2046-4053 (online)
dc.identifier.otherdoi:10.1186/2046-4053-2-106
dc.identifier.urihttp://hdl.handle.net/10019.1/95573
dc.descriptionCITATION: Machingaidze, S. et al. 2013. Understanding interventions for improving routine immunization coverage in children in low- and middle-income countries: a systematic review protocol. Systematic Reviews, 2(1):106, doi:10.1186/2046-4053-2-106.en_ZA
dc.descriptionThe original publication is available at http://www.systematicreviewsjournal.com/content/2/1/106en_ZA
dc.description.abstractBackground: Virtually all low- and middle-income countries are dependent on the World Health Organization’s Expanded Program on Immunization for delivery of vaccines to children. The Expanded Program on Immunization delivers routine immunization services from health facilities free of charge. Understanding interventions for improving immunization coverage remains key in achieving universal childhood immunization. Methods: We will conduct a systematic review that aims to assess the effectiveness of the full range of potential interventions to improve routine immunization coverage in children in low- and middle-income countries. We will include intervention studies, as well as observational studies. We will search the Cochrane Database of Systematic Reviews (CDSR), Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, electronic databases for eligible studies published by 31 August 2013. At least two authors will independently screen search outputs, select studies, extract data and assess the risk of bias (using separate criteria for interventions and observational studies); resolving any disagreements by discussion and consensus. The use of logic models and the Cochrane Complexity Matrix will be explored in order to better understand and contextualize studies. We will express the result of each study as a risk ratio with its corresponding 95% confidence intervals for dichotomous data, or mean difference with its standard deviation for continuous data. We will conduct meta-analysis for the same type of participants, interventions, study designs, and outcome measures where homogeneity of data allows. Use of harvest plots may be explored as an alternative. Heterogeneity will be assessed using the χ2 test of heterogeneity, and quantified using the I2 statistic. This protocol has not been registered with PROSPERO. Discussion: This review will allow us to document evidence across a broad range of intervention types for improving routine immunization coverage in children and also distinguish between those that are well supported by evidence (to direct policy recommendations) and those that are not well supported (to direct research agenda).en_ZA
dc.format.extent5 pages
dc.language.isoen_ZAen_ZA
dc.publisherBioMed Centralen_ZA
dc.subjectImmunization of children -- Developing countriesen_ZA
dc.subjectImmunization of infants -- Developing countriesen_ZA
dc.subjectVaccination of children -- Developing countriesen_ZA
dc.subjectWorld Health Organization. Expanded Programme on Immunizationen_ZA
dc.subjectVaccination of infants -- Developing countriesen_ZA
dc.titleUnderstanding interventions for improving routine immunization coverage in children in low- and middle-income countries : a systematic review protocolen_ZA
dc.typeArticleen_ZA
dc.date.updated2014-04-05T15:13:54Z
dc.description.versionPublishers' versionen_ZA
dc.rights.holderShingai Machingaidze et al.; licensee BioMed Central Ltd.en_ZA


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