• An analysis of adverse events and human error associated with the imaging of patients at a major trauma centre in South Africa 

      Bashir, A. A.; Kong, V. Y.; Buitendag, J. J. P.; Manchev, V.; Bekker, W.; Bruce, J. L.; Laing, G. L.; Brysiewicz, P.; Clarke, D. L. (Health & Medical Publishing Group, 2019)
      Background. There is growing realisation that human error contributes significantly to morbidity and mortality in modern healthcare. A number of taxonomies and classification systems have been developed in an attempt to ...
    • Antibacterial activities of crude secondary metabolite extracts from pantoea species obtained from the stem of solanum mauritianum and their effects on two cancer cell lines 

      Uche-Okereafor, Nkemdinma; Sebola, Tendani; Tapfuma, Kudzanai; Mekuto, Lukhanyo; Green, Ezekiel; Mavumengwana, Vuyo (MDPI, 2019)
      Endophytes are microorganisms that are perceived as non-pathogenic symbionts found inside plants since they cause no symptoms of disease on the host plant. Soil conditions and geography among other factors contribute to ...
    • Bedaquiline microheteroresistance after cessation of tuberculosis treatment 

      de Vos, Margaretha; Wiggins, Kristin B.; Derendinger, Brigitta; Reuter, Anja; Dolby, Tania; Burns, Scott; Schito, Marco; Engelthaler, David M.; Metcalfe, John; Theron, Grant; van Rie, Annelies; Posey, James; Warren, Rob; Cox, Helen (Massachusetts Medical Society, 2019-05-30)
      Bedaquiline improves survival among persons with multidrug-resistant tuberculosis (MDR-TB).1 We report the case of a 65-year-old South African man who was negative for human immunodeficiency virus and in whom MDR-TB was ...
    • A calix[4]arene based boronic acid catalyst for amide bond formation: proof of principle study 

      Mafaune, Asslly Tafara; Arnott, Gareth E. (2019-06-25)
      ENGLISH ABSTRACT: A calix[4]arene boronic acid was synthesized and tested for catalysis in amide formation. The results were positive and paved the way for future designs, even though protodeboronation was observed under ...
    • Chronic kidney disease in sub-Saharan Africa 

      Matsha, Tandi E.; Erasmus, Rajiv T. (Elsevier, 2019)
      No abstract available.
    • The collapsible nature of residual granite soils of the Cape Granite Suite 

      Fouche, N.; Asante, S. Y. (South African Institution of Civil Engineering, 2019)
      No abstract available.
    • Detection of second line drug resistance among drug resistant Mycobacterium tuberculosis isolates in Botswana 

      Mogashoa, Tuelo; Melamu, Pinkie; Derendinger, Brigitta; Ley, Serej D.; Streicher, Elizabeth M.; Iketleng, Thato; Mupfumi, Lucy; Mokomane, Margaret; Kgwaadira, Botshelo; Rankgoane-Pono, Goabaone; Tsholofelo, Thusoyaone T.; Kasvosve, Ishmael; Moyo, Sikhulile; Warren, Robin M.; Gaseitsiwe, Simani (MDPI, 2019-10-28)
      ENGLISH ABSTRACT: The emergence and transmission of multidrug resistant (MDR) and extensively drug resistant (XDR) Mycobacterium tuberculosis (M.tb) strains is a threat to global tuberculosis (TB) control. The early detection ...
    • Effect of Universal Testing and Treatment on HIV Incidence — HPTN 071 (PopART) 

      Hayes, Richard J.; Donnell, Deborah; Floyd, Sian; Mandla, Nomtha; Bwalya, Justin; Sabapathy, Kalpana; Yang, Blia; Phiri, Mwelwa; Schaap, Ab; Eshleman, Susan H.; Piwowar-Manning, Estelle; Kosloff, Barry; James, Anelet; Skalland, Timothy; Wilson, Ethan; Emel, Lynda; Macleod, David; Dunbar, Rory; Simwinga, Musonda; Makola, Nozizwe; Bond, Virginia; Moore, Ayana; Griffith, Sam; Sista, Nirupama Deshmane; Vermund, Sten H.; El-Sadr, Wafaa; Burns, David N.; Hargreaves, James R.; Hauck, Katharina; Fraser, Christophe; Shanaube, Kwame; Bock, Peter; Beyers, Nulda; Ayles, Helen; Fidler, Sarah (Massachusetts Medical Society, 2019-07-18)
      BACKGROUND: A universal testing and treatment strategy is a potential approach to reduce the incidence of human immunodeficiency virus (HIV) infection, yet previous trial results are inconsistent. METHODS: In the HPTN ...
    • Final analysis of a trial of M72/AS01E vaccine to prevent tuberculosis 

      Tait, D. R.; Hatherill, M.; Van Der Meeren, O.; Ginsberg, A. M.; Van Brakel, E.; Salaun, B.; Scriba, T. J.; Akite, E. J.; Ayles, H. M.; Bollaerts, A.; Demoitie, M. -A.; Diacon, A.; Evans, T. G.; Gillard, P.; Hellstrom, E.; Innes, J. C.; Lempicki, M.; Malahleha, M.; Martinson, N.; Vela, D. Mesia; Muyoyeta, M.; Nduba, V.; Pascal, T. G.; Tameris, M.; Thienemann, F.; Wilkinson, R. J.; Roman, F. (Massachusetts Medical Society, 2019-12-19)
      BACKGROUND: Results of an earlier analysis of a trial of the M72/AS01E candidate vaccine against Mycobacterium tuberculosis showed that in infected adults, the vaccine provided 54.0% protection against active pulmonary ...
    • Four-year review of admissions to a South African regional hospital general surgery department 

      Pape, J.; Swart, O.; Duvenage, R. (Health & Medical Publishing Group, 2019)
      Background. There are limited published data describing surgical admissions at a regional hospital level in the South African (SA) context. Objectives. To retrospectively review data from an electronic discharge summary ...
    • Implementation of a performance-grade bitumen specification in South Africa 

      Bredenhann, Steph; Myburgh, P. A.; Jenkins, Kim J.; O’Connell, Johan; Rowe, Geoff; D’Angelo, John (South African Institution of Civil Engineering, 2019-09)
      South Africa has been experiencing higher traffic volumes and heavier loads over the past several years. This has been accompanied by an increase in premature asphalt failures. Selection of the appropriate asphalt binder ...
    • Improving perioperative pain management: a preintervention and postintervention study in 7 developing countries 

      Zaslansky, Ruth; Chapman, C. Richard; Baumbach, Philipp; Bytyqi, Adem; Lopes, Jose M. Castro; Chetty, Sean; Kopf, Andreas; Li, Li; Ming, Lim Ern; Olawoye, Olayinka; Parico, Jane Rizza; Soyannwo, Olaitan; Stamenkovic, Dusica; Wang, Hongwei; Meissner, Winfried (Wolters Kluwer Health, 2019-01-01)
      Introduction: The burden of untreated postoperative pain is high. Objective: This study assessed feasibility of using quality improvement (QI) tools to improve management of perioperative pain in hospitals in multiple ...
    • Increasing access to integrated ESKD care as part of universal health coverage 

      Harris, David C. H.; Davies, Simon J.; Finkelstein, Fredric O.; Jha, Vivekanand; Donner, Jo-Ann; Abraham, Georgi; Bello, Aminu K.; Caskey, Fergus J.; Garcia, Guillermo Garcia; Harden, Paul; Hemmelgarn, Brenda; Johnson, David W.; Levin, Nathan W.; Luyckx, Valerie A.; Martin, Dominique E.; McCulloch, Mignon I.; Moosa, Mohammed Rafique; O’Connell, Philip J.; Okpechi, Ikechi G.; Filho, Roberto Pecoits; Shah, Kamal D.; Sola, Laura; Swanepoel, Charles; Tonelli, Marcello; Twahir, Ahmed; van Biesen, Wim; Varghese, Cherian; Yang, Chih-Wei; Zuniga, Carlos (Elsevier, 2019)
      The global nephrology community recognizes the need for a cohesive strategy to address the growing problem of end-stage kidney disease (ESKD). In March 2018, the International Society of Nephrology hosted a summit on ...
    • Inflammation and oxidative stress in an obese state and the protective effects of gallic acid 

      Dludla, Phiwayinkosi V.; Nkambule, Bongani B.; Jack, Babalwa; Mkandla, Zibusiso; Mutize, Tinashe; Silvestri, Sonia; Orlando, Patrick; Tiano, Luca; Louw, Johan; Mazibuko-Mbeje, Sithandiwe E. (MDPI, 2019)
      Metabolic complications in an obese state can be aggravated by an abnormal inflammatory response and enhanced production of reactive oxygen species. Pro-inflammatory response is known to be associated with the formation ...
    • The influence of gradient on saturation flow rate at signalised intersections 

      Bruwer, Megan M.; Bester, Christo J.; Viljoen, Elizabeth S. (South African Institution of Civil Engineering, 2019-06)
      Saturation flow rate is the maximum hourly traffic volume per lane that can be accommodated through an intersection, and is used in the design and analysis of signalised intersections and traffic signal plans. The most ...
    • Investigation of flow regime transition in a column flotation cell using CFD 

      Mwandawande, I.; Akdogan, G.; Bradshaw, S. M.; Karimi, M.; Snyders, N. (Southern African Institute of Mining and Metallurgy, 2019-02)
      ENGLISH ABSTRACT: Flotation columns are normally operated at optimal superficial gas velocities to maintain bubbly flow conditions. However, with increasing superficial gas velocity, loss of bubbly flow may occur with ...
    • Isoniazid Preventive Therapy in HIV-Infected Pregnant and Postpartum Women 

      Gupta, Amita; Montepiedra, Grace; Aaron, Lisa; Theron, Gerhard; McCarthy, Katie; Bradford, Sarah; Chipato, Tsungai; Vhembo, Tichaona; Stranix-Chibanda, Lynda; Onyango-Makumbi, Carolyne; Masheto, Gaerolwe R.; Mmbaga, Blandina T.; Aurpibul, Linda; Bhosale, Ramesh; Mave, Vidya; Rouzier, Vanessa; Hesseling, Anneke; Shin, Katherine; Zimmer, Bonnie; Costello, Diane; Sterling, Timothy R.; Chakhtoura, Nahida; Jean-Philippe, Patrick; Weinberg, Adriana (Massachusetts Medical Society, 2019-10-03)
      BACKGROUND: The safety, efficacy, and appropriate timing of isoniazid therapy to prevent tuberculosis in pregnant women with human immunodeficiency virus (HIV) infection who are receiving antiretroviral therapy are ...
    • The level of the endoplasmic reticulum stress chaperone protein, binding immunoglobulin protein (BiP), decreases following successful tuberculosis treatment 

      Motaung, Bongani; Walzl, Gerhard; Loxton, Andre G. (Elsevier, 2019)
      An increased Mycobacterium tuberculosis burden inside the host leads to higher demand of response proteins. This in turn results in metabolic shift and cellular stress, which is caused by the accumulation and trafficking ...
    • Long-term impact of neonatal intake of oleanolic acid on the expression of AMP-activated protein kinase, adiponectin and inflammatory cytokines in rats fed with a high fructose diet 

      Matumba, Mashudu Given; Ayeleso, Ademola Olabode; Nyakudya, Trevor; Erlwanger, Kennedy; Chegou, Novel N.; Mukwevho, Emmanuel (MDPI, 2019-01-22)
      AMP-activated protein kinase (AMPK) is known to regulate both glucose and lipid metabolism, which play vital roles in the development of metabolic syndrome. One way of regulating AMPK is through hormonal activation using ...
    • MicroCT-based bulk density measurement method for soils 

      Le Roux, S. G.; Du Plessis, A.; Clarke, C. E. (South African Institution of Civil Engineering, 2019)
      High-resolution micro-computed tomography (microCT) is a method growing rapidly in popularity and has been applied to various soil studies with great success, especially for 3D characterisation of pore spaces or mineral ...