Onyalai - therapeutic effects of vincristine sulphate : a prospective randomized trial

Hesseling, P. B. ; Girdle-Brown, B. ; Smith, J. (1986-08)

Please cite as follows: Hesseling, P. B., Girdle-Brown, B. & Smit. J. 1986. Onyalai - Therapeutic effects of vincristine sulphate: A prospective randomized trial. S Afr Med J, 70:201-202.

The original publication is available at http://www.samj.org.za


Twenty out of 40 patients with onyalai admitted to Rundu State Hospital, Kavango, SWA/Namibia, were randomized to receive a vincristine sulphate bolus of 1,5 mg/m2 or an equivalent volume of normal saline intravenously on days 8 and 15 when haemorrhage or a platelet count of less than 50 x 109/l persisted for more than 1 week after admission. All patients were observed in hospital for at least 21 days. Five out of 10 patients who received vincristine achieved a platelet count in excess of 100 x 109/l on day 21 and only 2 out of 10 patients who received placebo achieved a similar rise in the platelet count. Two patients, neither of whom was treated with vincristine, died of cerebral haemorrhage.

Please refer to this item in SUNScholar by using the following persistent URL: http://hdl.handle.net/10019.1/7978
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