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Medication possession ratio associated with short-term virologic response in individuals initiating antiretroviral therapy in Namibia

dc.contributor.authorHong, Steven Y.en_ZA
dc.contributor.authorJerger, Loganen_ZA
dc.contributor.authorJonas, Annaen_ZA
dc.contributor.authorBadi, Alfonsen_ZA
dc.contributor.authorCohen, Stevenen_ZA
dc.contributor.authorNachega, Jean B.en_ZA
dc.contributor.authorParienti, Jean-Jacquesen_ZA
dc.contributor.authorTang, Alice M.en_ZA
dc.contributor.authorWanke, Christineen_ZA
dc.contributor.authorTerrin, Normaen_ZA
dc.contributor.authorPereko, Dawnen_ZA
dc.contributor.authorBlom, Abrahamen_ZA
dc.contributor.authorTrotter, Andrew B.en_ZA
dc.contributor.authorJordan, Michael R.en_ZA
dc.date.accessioned2013-03-11T14:01:57Z
dc.date.available2013-03-11T14:01:57Z
dc.date.issued2013
dc.identifier.citationHong, S. Y., et al. 2013. Medication possession ratio associated with short-term virologic response in individuals initiating antiretroviral therapy in Namibia. PLoS ONE, 8(2): 1-7, doi: 10.1371/journal.pone.0056307
dc.identifier.issn1932-6203 (online)
dc.identifier.issn1932-6203 (print)
dc.identifier.otherdoi: 10.1371/journal.pone.0056307
dc.identifier.urihttp://hdl.handle.net/10019.1/79747
dc.descriptionCITATION: Hong, S. Y., et al. 2013. Medication possession ratio associated with short-term virologic response in individuals initiating antiretroviral therapy in Namibia. PLoS ONE, 8(2): 1-7, doi: 10.1371/journal.pone.0056307.
dc.descriptionThe original publication is available at http://journals.plos.org/plosone
dc.description.abstractENGLISH ABSTRACT: The visual-analogue scale (VAS), Likert item (rating scale), pills identification test (PIT), and medication possession ratio (MPR) provide estimates of antiretroviral therapy (ART) adherence which correlate with HIV viral suppression. These simple adherence measures are inexpensive and easy to administer; however, require validation and adjustment prior to implementation. The objective of this study was to define the optimal adherence assessment measure in Namibia to identify patients at risk for sub-optimal adherence and poor virologic response 6 months after ART initiation. We conducted a crosssectional survey in HIV-infected adults receiving ART for 6–12 months prior to the adherence assessment. Adherence measures included 30-day VAS, 30-day Likert item, self-reported treatment interruptions, PIT, and MPR. Association of adherence measures with 6-month HIV-1 RNA level was assessed using two thresholds (1000 copies/mL and 5000 copies/mL). Adherence was assessed in 236 patients, mean age 37.3 years, 54% female. Mean adherence was 98.1% by 30-day VAS, 84.7% by 30-day Likert item, 97.0% by self-reported treatment interruptions, 90.6% by PIT, and 98.8% by MPR. Agreement between adherence measures was poor using kappa statistic. 76% had HIV-1 RNA ,1000 copies/ml, and 88% had HIV-1 RNA ,5000 copies/ml. MPR (continuous) was associated with viral suppression ,5000 copies/ml (p = 0.036). MPR ,75% was associated with virologic failure at $5000 copies/ml with OR 3.89 (1.24, 12.21), p = 0.013. Adherence was high with all measures. Only MPR, was associated with short-term virologic response, suggesting its cross-culturally utility for early identification of patients at high risk for virologic failure.en_ZA
dc.description.urihttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0056307
dc.format.extent7 pagesen_ZA
dc.language.isoen_ZAen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.subjectVisual-analogue scaleen_ZA
dc.subjectPillsen_ZA
dc.subjectAntiretroviral agentsen_ZA
dc.subjectMedical virologyen_ZA
dc.titleMedication possession ratio associated with short-term virologic response in individuals initiating antiretroviral therapy in Namibiaen_ZA
dc.typeArticleen_ZA
dc.description.versionPublisher's versionen_ZA
dc.rights.holderAuthors retain copyrighten_ZA


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