Diagnostic problems of leptomeningeal lymphoma : a report of 3 cases
CITATION: Gardiner, A., De Graaf, A. S. & Hewlett, R. H. 1987. Diagnostic problems of leptomeningeal lymphoma : a report of 3 cases. South African Medical Journal, 71:457-459.
The original publication is available at http://www.samj.org.za
Three cases are presented in which occult lymphoreticular malignant tumour spread to the spinal and cranial subarachnoid spaces inducing a problematic neurological illness characterised by poorly localised neuralgic pain, slowly progressive paresis and, in 2 patients, papilloedema with computed tomographic evidence of ventricular dilatation. Despite intensive investigations, diagnosis was only achieved at autopsy. A progressive disturbance of spinal and cranial nerve function should direct the attention of the clinician to the possibility of diffuse meningeal involvement by a malignant or inflammatory process.