Desmond Tutu TB Centre (Tygerberg)
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Burden, spectrum and outcomes of children with tuberculosis diagnosed at a district-level hospital in South Africa
(International Union Against Tuberculosis and Lung Disease, 2018)SETTING: The Khayelitsha subdistrict has the highest burden of reported tuberculosis (TB) cases in Cape Town, Western Cape Province, South Africa. OBJECTIVES: To characterise the TB burden, spectrum and treatment outcomes ... -
Opportunities for mobile app–based adherence support for children with tuberculosis in South Africa
(JMIR Publications, 2020)ENGLISH ABSTRACT: Tuberculosis is the number one infectious cause of death globally. Young children, generally those younger than 5 years, are at the highest risk of progressing from tuberculosis infection to tuberculosis ... -
Closing the reporting gap for childhood tuberculosis in South Africa : improving hospital referrals and linkages
(IUATLD -- International Union Against Tuberculosis and Lung Disease, 2020-03-21)Setting: A referral hospital in Cape Town, Western Cape Province, Republic of South Africa. Objective: To measure the impact of a hospital-based referral service (intervention) to reduce initial loss to follow-up among ... -
Global shortages of BCG vaccine and tuberculous meningitis in children
(Elsevier, 2019)ENGLISH ABSTRACT: No abstract available. -
Retention in care and factors critical for effectively implementing antiretroviral adherence clubs in a rural district in South Africa
(Wiley Open Access, 2019-09-03)Introduction: Differentiated models of care that include referral of antiretroviral treatment (ART) clients to adherence clubs are an important strategy to help clinics manage increased number of clients living with HIV ... -
Protecting children in low-income and middle-income countries from COVID-19
(BMJ, 2020)A saving grace of the COVID-19 pandemic in high-income and upper middle-income countries has been the relative sparing of children. As the disease spreads across low-income and middle-income countries (LMICs), ... -
Provider attitudes about childhood tuberculosis prevention in Lesotho : a qualitative study
(BMC (part of Springer Nature), 2020-05-25)Background: The World Health Organization estimated that 1.12 million children developed tuberculosis (TB) in 2018, and at least 200,000 children died from TB. Implementation of effective child contact management is ... -
Towards 90-90 : findings after two years of the HPTN 071 (PopART) cluster-randomized trial of a universal testing-and-treatment intervention in Zambia
(Public Library of Science, 2018)Background: HPTN071(PopART) is a 3-arm community-randomised study in 21 peri-urban/urban communities in Zambia and the Western Cape of South Africa, with high HIV prevalence and high mobility especially among young adults. ... -
Attrition when providing antiretroviral treatment at CD4 counts >500cells/μL at three government clinics included in the HPTN 071 (PopART) trial in South Africa
(Public Library of Science, 2018-04-19)Introduction: WHO recommends antiretroviral treatment (ART) for all HIV-positive individuals. This study evaluated the association between baseline CD4 count and attrition in a cohort of HIV positive adults initiating ART ... -
C-Tb skin test to diagnose Mycobacterium tuberculosis infection in children and HIV infected adults : a phase 3 trial
(Public Library of Science, 2018)Background C-Tb, an ESAT-6/CFP-10-based skin test, has similar sensitivity for active TB compared to tuberculin skin test (TST) and QuantiFERON-TB-Gold-In-Tube (QFT). However, data are limited in children and HIV-infected ... -
Factors associated with linkage to HIV care and TB treatment at community-based HIV testing services in Cape Town, South Africa
(Public Library of Science, 2018-04-02)Background Diagnosing HIV and/or TB is not sufficient; linkage to care and treatment is conditional to reduce the burden of disease. This study aimed to determine factors associated with linkage to HIV care and TB treatment ... -
Rapid point-of-care CD4 testing at mobile units and linkage to HIV care : an evaluation of community-based mobile HIV testing services in South Africa
(BMC (part of Springer Nature), 2020)Background: Mobile HIV testing services (HTS) are effective at reaching undiagnosed people living with HIV. However, linkage to HIV care from mobile HTS is often poor, ranging from 10 to 60%. Point-of-care (POC) CD4 testing ... -
Tuberculosis control interventions targeted to previously treated people in a high-incidence setting : a modelling study
(Elsevier, 2018-02-19)Background In high-incidence settings, recurrent disease among previously treated individuals contributes substantially to the burden of incident and prevalent tuberculosis. The extent to which interventions targeted to ... -
Potential effect of household contact management on childhood tuberculosis : a mathematical modelling study
(Elsevier, 2018)Summary Background Tuberculosis is recognised as a major cause of morbidity and mortality in children, with most cases in children going undiagnosed and resulting in poor outcomes. Household contact management, which ... -
Spinning plates : livelihood mobility, household responsibility and anti-retroviral treatment in an urban Zambian community during the HPTN 071 (PopART) study
(Wiley Open Access, 2018)Introduction: Qualitative data are lacking on the impact of mobility among people living with HIV (PLHIV) and their decisionmaking around anti-retroviral treatment (ART). We describe challenges of juggling household ... -
Households, fluidity, and HIV service delivery in Zambia and South Africa – an exploratory analysis of longitudinal qualitative data from the HPTN 071 (PopART) trial
(Wiley Open Access, 2018)Introduction: Population distributions, family and household compositions, and people’s sense of belonging and social stability in southern Africa have been shaped by tumultuous, continuing large-scale historical disruptions. ... -
Where are we in the battle of ending tuberculosis in children and adolescents in South Africa?
(Health & Medical Publishing Group, 2020)Ambitious targets to end tuberculosis (TB) were set at the United Nations General Assembly High-Level Meeting (UNHLM) on TB in September 2018, with children and adolescents specifically noted as key populations deserving ... -
TB transmission is associated with prolonged stay in a low socio-economic, high burdened TB and HIV community in Cape Town, South Africa
(BMC (part of Springer Nature), 2020-02-10)Background: While several studies have assessed the associations between biological factors and tuberculosis (TB) transmission, our understanding of the associations between TB transmission and social and economic ... -
Identification of subclinical tuberculosis in household contacts using exposure scores and contact investigations
(BMC (part of Springer Nature), 2020-01-31)Background: The goal of tuberculosis elimination put forward in the End TB Strategy prioritizes diagnosis and treatment of incipient and subclinical TB, recently defined by key stakeholders as “asymptomatic, early pre-clinical ... -
Community narratives about women and HIV risk in 21 high-burden communities in Zambia and South Africa
(Dove Medical Press, 2017)ENGLISH ABSTRACT: Public health researchers repeatedly represent women as a group vulnerable to ill health. This has been particularly true in the field of HIV research, where women are disproportionately affected by HIV ...
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