Desmond Tutu TB Centre (Tygerberg)
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Protecting children in low-income and middle-income countries from COVID-19
(BMJ, 2020)A saving grace of the COVID-19 pandemic in high-income and upper middle-income countries has been the relative sparing of children. As the disease spreads across low-income and middle-income countries (LMICs), ... -
Provider attitudes about childhood tuberculosis prevention in Lesotho : a qualitative study
(BMC (part of Springer Nature), 2020-05-25)Background: The World Health Organization estimated that 1.12 million children developed tuberculosis (TB) in 2018, and at least 200,000 children died from TB. Implementation of effective child contact management is ... -
Towards 90-90 : findings after two years of the HPTN 071 (PopART) cluster-randomized trial of a universal testing-and-treatment intervention in Zambia
(Public Library of Science, 2018)Background: HPTN071(PopART) is a 3-arm community-randomised study in 21 peri-urban/urban communities in Zambia and the Western Cape of South Africa, with high HIV prevalence and high mobility especially among young adults. ... -
Attrition when providing antiretroviral treatment at CD4 counts >500cells/μL at three government clinics included in the HPTN 071 (PopART) trial in South Africa
(Public Library of Science, 2018-04-19)Introduction: WHO recommends antiretroviral treatment (ART) for all HIV-positive individuals. This study evaluated the association between baseline CD4 count and attrition in a cohort of HIV positive adults initiating ART ... -
C-Tb skin test to diagnose Mycobacterium tuberculosis infection in children and HIV infected adults : a phase 3 trial
(Public Library of Science, 2018)Background C-Tb, an ESAT-6/CFP-10-based skin test, has similar sensitivity for active TB compared to tuberculin skin test (TST) and QuantiFERON-TB-Gold-In-Tube (QFT). However, data are limited in children and HIV-infected ... -
Factors associated with linkage to HIV care and TB treatment at community-based HIV testing services in Cape Town, South Africa
(Public Library of Science, 2018-04-02)Background Diagnosing HIV and/or TB is not sufficient; linkage to care and treatment is conditional to reduce the burden of disease. This study aimed to determine factors associated with linkage to HIV care and TB treatment ... -
Rapid point-of-care CD4 testing at mobile units and linkage to HIV care : an evaluation of community-based mobile HIV testing services in South Africa
(BMC (part of Springer Nature), 2020)Background: Mobile HIV testing services (HTS) are effective at reaching undiagnosed people living with HIV. However, linkage to HIV care from mobile HTS is often poor, ranging from 10 to 60%. Point-of-care (POC) CD4 testing ... -
Tuberculosis control interventions targeted to previously treated people in a high-incidence setting : a modelling study
(Elsevier, 2018-02-19)Background In high-incidence settings, recurrent disease among previously treated individuals contributes substantially to the burden of incident and prevalent tuberculosis. The extent to which interventions targeted to ... -
Potential effect of household contact management on childhood tuberculosis : a mathematical modelling study
(Elsevier, 2018)Summary Background Tuberculosis is recognised as a major cause of morbidity and mortality in children, with most cases in children going undiagnosed and resulting in poor outcomes. Household contact management, which ... -
Spinning plates : livelihood mobility, household responsibility and anti-retroviral treatment in an urban Zambian community during the HPTN 071 (PopART) study
(Wiley Open Access, 2018)Introduction: Qualitative data are lacking on the impact of mobility among people living with HIV (PLHIV) and their decisionmaking around anti-retroviral treatment (ART). We describe challenges of juggling household ... -
Households, fluidity, and HIV service delivery in Zambia and South Africa – an exploratory analysis of longitudinal qualitative data from the HPTN 071 (PopART) trial
(Wiley Open Access, 2018)Introduction: Population distributions, family and household compositions, and people’s sense of belonging and social stability in southern Africa have been shaped by tumultuous, continuing large-scale historical disruptions. ... -
Where are we in the battle of ending tuberculosis in children and adolescents in South Africa?
(Health & Medical Publishing Group, 2020)Ambitious targets to end tuberculosis (TB) were set at the United Nations General Assembly High-Level Meeting (UNHLM) on TB in September 2018, with children and adolescents specifically noted as key populations deserving ... -
TB transmission is associated with prolonged stay in a low socio-economic, high burdened TB and HIV community in Cape Town, South Africa
(BMC (part of Springer Nature), 2020-02-10)Background: While several studies have assessed the associations between biological factors and tuberculosis (TB) transmission, our understanding of the associations between TB transmission and social and economic ... -
Identification of subclinical tuberculosis in household contacts using exposure scores and contact investigations
(BMC (part of Springer Nature), 2020-01-31)Background: The goal of tuberculosis elimination put forward in the End TB Strategy prioritizes diagnosis and treatment of incipient and subclinical TB, recently defined by key stakeholders as “asymptomatic, early pre-clinical ... -
Community narratives about women and HIV risk in 21 high-burden communities in Zambia and South Africa
(Dove Medical Press, 2017)ENGLISH ABSTRACT: Public health researchers repeatedly represent women as a group vulnerable to ill health. This has been particularly true in the field of HIV research, where women are disproportionately affected by HIV ... -
Levofloxacin versus placebo for the prevention of tuberculosis disease in child contacts of multidrug-resistant tuberculosis : study protocol for a phase III cluster randomised controlled trial (TB-CHAMP)
(BMC (part of Springer Nature), 2018-12-20)Background: Multidrug-resistant (MDR) tuberculosis (TB) presents a challenge for global TB control. Treating individuals with MDR-TB infection to prevent progression to disease could be an effective public health ... -
Understanding low sensitivity of community-based HIV rapid testing : experiences from the HPTN 071 (PopART) trial in Zambia and South Africa
(Wiley Open Access, 2017-08-27)Introduction: Population-wide HIV testing services (HTS) must be delivered in order to achieve universal antiretroviral treatment (ART) coverage. To accurately deliver HTS at such scale, non-facility-based HIV point-of-care ... -
Shorter treatment for minimal tuberculosis (TB) in children (SHINE) : a study protocol for a randomised controlled trial
(BioMed Central, 2018-04-19)Background: Tuberculosis (TB) in children is frequently paucibacillary and non-severe forms of pulmonary TB are common. Evidence for tuberculosis treatment in children is largely extrapolated from adult studies. Trials in ... -
Complementary surveillance strategies are needed to better characterise the epidemiology, care pathways and treatment outcomes of tuberculosis in children
(BioMed Central, 2018-03-23)Background: Tuberculosis (TB) in young and HIV-infected children is frequently diagnosed at hospital level. In settings where general hospitals do not function as TB reporting units, the burden and severity of childhood ... -
Cost analysis of two community-based HIV testing service modalities led by a Non-Governmental Organization in Cape Town, South Africa
(BioMed Central, 2017-12-02)Background: In South Africa, the financing and sustainability of HIV services is a priority. Community-based HIV testing services (CB-HTS) play a vital role in diagnosis and linkage to HIV care for those least likely to ...
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