Desmond Tutu TB Centre (Tygerberg)
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Knowledge gaps and research priorities in tuberculous meningitis
(Wellcome Open Research, 2019-11-28)ENGLISH ABSTRACT: Tuberculous meningitis (TBM) is the most severe and disabling form of tuberculosis (TB), accounting for around 1-5% of the global TB caseload, with mortality of approximately 20% in children and up to 60% ... -
Decision-making in the diagnosis of tuberculous meningitis
(Wellcome Open Research, 2020-01-23)ENGLISH ABSTRACT: Tuberculous meningitis (TBM) is the most devastating form of tuberculosis (TB) but diagnosis is difficult and delays in initiating therapy increase mortality. All currently available tests are imperfect; ... -
Tuberculous meningitis : new tools and new approaches required [version 1; peer review: not peer reviewed]
(F1000Research, 2019)ENGLISH ABSTRACT: Tuberculous meningitis is the most severe form of tuberculosis and causes widespread mortality and morbidity. Understanding of the epidemiology and pathogenesis is incomplete, and the optimal diagnosis ... -
The current global situation for tuberculous meningitis : epidemiology, diagnostics, treatment and outcomes [version 1; peer review: 2 approved]
(F1000Research, 2019)ENGLISH ABSTRACT: Tuberculous meningitis (TBM) results from dissemination of M. tuberculosis to the cerebrospinal fluid (CSF) and meninges. Ischaemia, hydrocephalus and raised intracranial pressure frequently result, leading ... -
Renal dysfunction by baseline CD4 cell count in a cohort of adults starting antiretroviral treatment regardless of CD4 count in the HIV Prevention Trials Network 071 [HPTN 071; Population Effect of Antiretroviral Therapy to Reduce HIV Transmission (PopART)] study in South Africa
(Wiley, 2019)Objectives: Renal dysfunction is a significant cause of morbidity and mortality among HIV-positive individuals. This study evaluated renal dysfunction in a cohort of adults who started antiretroviral treatment (ART) ... -
Morbidity and mortality up to 5 years post tuberculosis treatment in South Africa : a pilot study
(Elsevier, 2019)Background: A high risk of tuberculosis (TB), chronic lung disease, and mortality have been reported among people with a history of previous TB treatment, but data from high-incidence settings remain limited. The aim of ... -
Point of care Xpert MTB/RIF versus smear microscopy for tuberculosis diagnosis in southern African primary care clinics : a multicentre economic evaluation
(Elsevier, 2019-06-01)Background: Rapid on-site diagnosis facilitates tuberculosis control. Performing Xpert MTB/RIF (Xpert) at point of care is feasible, even when performed by minimally trained health-care workers, and when compared with ... -
Inclusion of key populations in clinical trials of new antituberculosis treatments : current barriers and recommendations for pregnant and lactating women, children, and HIV-infected persons
(Public Library of Science, 2019)ENGLISH ABSTRACT: Pregnant women, children < 15 years old and, HIV-infected persons contribute approximately 20% of the global tuberculosis (TB) burden, with an estimated 216,000, 1,000,000, and 1,040,000 cases each ... -
Pharmacokinetics, optimal dosing, and safety of linezolid in children with multidrugresistant tuberculosis : combined data from two prospective observational studies
(Public Library of Science, 2019)Background: Linezolid is increasingly important for multidrug-resistant tuberculosis (MDR-TB) treatment. However, among children with MDR-TB, there are no linezolid pharmacokinetic data, and its adverse effects have not ... -
Development and validation of a prediction model for active tuberculosis case finding among HIV-negative/unknown populations
(Nature Research (part of Springer Nature), 2019)ENGLISH ABSTRACT: A prediction model of prevalent pulmonary tuberculosis (TB) in HIV negative/unknown individuals was developed to assist systematic screening. Data from a large TB screening trial were used. A multivariable ... -
Evaluation of adherence monitoring system using evriMED with a differentiated response compared to standard of care among drug-sensitive TB patients in three provinces in South Africa : a protocol for a cluster randomised control trial
(BMC (part of Springer Nature), 2021-06-09)Background: South Africa has achieved drug-susceptible TB (DS-TB) treatment success of only 77% among people with new and previously treated TB. Alternative approaches are required to improve medication adherence ... -
Health system determinants of tuberculosis mortality in South Africa : a causal loop model
(BMC (part of Springer Nature), 2021-04-26)Background: Tuberculosis (TB) is a major public health concern in South Africa and TB-related mortality remains unacceptably high. Numerous clinical studies have examined the direct causes of TB-related mortality, but its ... -
A philosophical perspective on pulmonary hypertension : what is 'rare'?
(ASSAf, 2020-05-27)ENGLISH ABSTRACT: Pulmonary hypertension (PH) is a fatal disease and public health concern.1 The global prevalence of PH is not known1 and a major focus is to establish registries in order to determine the actual prevalence ... -
Impact of systematic early tuberculosis detection using Xpert MTB/RIF Ultra in children with severe pneumonia in high tuberculosis burden countries (TB-Speed pneumonia) : a stepped wedge cluster randomized trial
(BMC (part of Springer Nature), 2021-03-20)Background: In high tuberculosis (TB) burden settings, there is growing evidence that TB is common in children with pneumonia, the leading cause of death in children under 5 years worldwide. The current WHO standard ... -
High burden of viral respiratory co-infections in a cohort of children with suspected pulmonary tuberculosis
(BMC (part of Springer Nature), 2020-12-04)Background: The presentation of pulmonary tuberculosis (PTB) in young children is often clinically indistinguishable from other common respiratory illnesses, which are frequently infections of viral aetiology. As little is ... -
Stigma and HIV service access among transfeminine and gender diverse women in South Africa – a narrative analysis of longitudinal qualitative data from the HPTN 071 (PopART) trial
(BMC (part of Springer Nature), 2020-12-10)Background: Transgender women have a disproportionately high HIV prevalence compared to cisgender women and men who have sex with men, which puts them at risk of HIV-related stigma (Baral SD et al., Lancet Infect Dis, 13;3, ... -
Burden, spectrum and outcomes of children with tuberculosis diagnosed at a district-level hospital in South Africa
(International Union Against Tuberculosis and Lung Disease, 2018)SETTING: The Khayelitsha subdistrict has the highest burden of reported tuberculosis (TB) cases in Cape Town, Western Cape Province, South Africa. OBJECTIVES: To characterise the TB burden, spectrum and treatment outcomes ... -
Opportunities for mobile app–based adherence support for children with tuberculosis in South Africa
(JMIR Publications, 2020)ENGLISH ABSTRACT: Tuberculosis is the number one infectious cause of death globally. Young children, generally those younger than 5 years, are at the highest risk of progressing from tuberculosis infection to tuberculosis ... -
Closing the reporting gap for childhood tuberculosis in South Africa : improving hospital referrals and linkages
(IUATLD -- International Union Against Tuberculosis and Lung Disease, 2020-03-21)Setting: A referral hospital in Cape Town, Western Cape Province, Republic of South Africa. Objective: To measure the impact of a hospital-based referral service (intervention) to reduce initial loss to follow-up among ... -
Global shortages of BCG vaccine and tuberculous meningitis in children
(Elsevier, 2019)ENGLISH ABSTRACT: No abstract available.
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