Browsing Research Articles (Biochemistry) by Title
Now showing items 1-20 of 72
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11-ketotestosterone and 11-ketodihydrotestosterone in castration resistant prostate cancer : potent androgens which can no longer be ignored
(Public Library of Science, 2016)Dihydrotestosterone (DHT) is regarded as the most potent natural androgen and is implicated in the development and progression of castration resistant prostate cancer (CRPC). Under castrate conditions, DHT is produced from ... -
11β-Hydroxyandrostenedione returns to the steroid arena : biosynthesis, metabolism and function
(MDPI, 2013-10)The biological significance of 11β-hydroxyandrostenedione (11OHA4) has eluded researchers for the past six decades. It is now known that 11OHA4 is biosynthesized in the androgen arm of the adrenal steroidogenesis pathway ... -
A fully dissociated compound of plant origin for inflammatory gene repression
(PNAS, 2005-11)The identification of selective glucocorticoid receptor (GR) modifiers, which separate transactivation and transrepression properties, represents an important research goal for steroid pharmacology. Although the gene-activating ... -
Abrogation of glucocorticoid receptor dimerization correlates with dissociated glucocorticoid behavior of compound A
(HighWire Press, 2010-03)Compound A (CpdA), a dissociated glucocorticoid receptor modulator, decreases corticosteroid-binding globulin (CBG), adrenocorticotropic hormone (ACTH), and luteneinizing hormone levels in rats. Whether this is due to ... -
Acetyl-4′-phosphopantetheine is stable in serum and prevents phenotypes induced by pantothenate kinase deficiency
(Nature Research, 2017-09-12)Coenzyme A is an essential metabolite known for its central role in over one hundred cellular metabolic reactions. In cells, Coenzyme A is synthesized de novo in five enzymatic steps with vitamin B5 as the starting metabolite, ... -
Anti-inflammatory effects of Aspalathus linearis and Cyclopia spp. extracts in a UVB/keratinocyte (HaCaT) model utilising interleukin-1α accumulation as biomarker
(MDPI, 2016-10-02)Ultraviolet B (UVB) radiation is one of the major predisposing risk factors of skin cancer. The anticancer and photoprotective effects of unoxidized rooibos (Aspalathus linearis) and honeybush (Cyclopia) herbal teas, ... -
The biodiversity hotspot as evolutionary hot-bed : spectacular radiation of Erica in the Cape Floristic Region
(BioMed Central, 2016-09-17)Background: The disproportionate species richness of the world’s biodiversity hotspots could be explained by low extinction (the evolutionary “museum”) and/or high speciation (the “hot-bed”) models. We test these models ... -
Chemoprevention of LA7-induced mammary tumor growth by SM6Met, a well-characterized cyclopia extract
(Frontiers, 2018)Breast cancer (BC) is the leading cause of cancer-related deaths in women. Chemoprevention of BC by using plant extracts is gaining attention. SM6Met, a wellcharacterized extract of Cyclopia subternata with reported ... -
Complex stability and dynamic subunit interchange modulates the disparate activities of the yeast moonlighting proteins Hal3 and Vhs3
(Springer Nature, 2015-10)Saccharomyces cerevisiae Hal3 and Vhs3 are moonlighting proteins, acting both as inhibitors of the serine/threonine protein phosphatase Ppz1 and as subunits (together with Cab3) of the unique heterotrimeric phosphopant ... -
Conservation implications of avian malaria exposure for African penguins during rehabilitation
(Academy of Science of South Africa, 2017-02-15)ENGLISH ABSTRACT: The African penguin (Spheniscus demersus) is the only penguin species that breeds on the African continent and it is currently classified as endangered. Its conservation is assisted by the Southern ... -
Consistent phenological shifts in the making of a biodiversity hotspot : the Cape flora
(BioMed Central, 2011-02)ABSTRACT: Background: The best documented survival responses of organisms to past climate change on short (glacial-interglacial) timescales are distributional shifts. Despite ample evidence on such timescales for local ... -
Cyclopia extracts act as ERα antagonists and ERβ agonists, in vitro and in vivo
(Public Library of Science (PLOS), 2013-11)Hormone replacement therapy associated risks, and the concomitant reluctance of usage, has instigated the search for new generations of estrogen analogues that would maintain estrogen benefits without associated ... -
Data comparing the separation and elution of vitamin D metabolites on an ultra performance supercritical fluid chromatography tandem-mass spectrometer (UPSFC-MS/MS) compared to liquid chromatography (LC) and data presenting approaches to UPSFC method optimization
(Elsevier, 2018)The data presented is related to the research article "Analysis of multiple vitamin D metabolites by ultra performance supercritical fluid chromatography-tandem mass spectrometry (UPSFC-MS/MS)" (Jenkinson et al., 2018) ... -
Degradation of synthetic xylan effluent using a membrane bioreactor
(Academy of Science for South Africa, 2003)We have built a novel membrane bioreactor for the degradation of synthetic xylan effluent. The reactor contains 30 internally skinned polysulphone membranes as an immobilization matrix for xylanase, the degrading agent, ... -
Delving deeper : relating the behaviour of a metabolic system to the properties of its components using symbolic metabolic control analysis
(Public Library of Science, 2018-11-28)High-level behaviour of metabolic systems results from the properties of, and interactions between, numerous molecular components. Reaching a complete understanding of metabolic behaviour based on the system’s components ... -
Determining enzyme kinetics for systems biology with nuclear magnetic resonance spectroscopy
(MDPI, 2012)Enzyme kinetics for systems biology should ideally yield information about the enzyme’s activity under in vivo conditions, including such reaction features as substrate cooperativity, reversibility and allostery, and be ... -
The development of computational biology in South Africa : successes achieved and lessons learnt
(PLoS, 2016)Bioinformatics is now a critical skill in many research and commercial environments as biological data are increasing in both size and complexity. South African researchers recognized this need in the mid-1990s and responded ... -
A dimer of the toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins
(Public Library of Science, 2007-08-29)The Toll-like receptor 4 (TLR4) is a class I transmembrane receptor expressed on the surface of immune system cells. TLR4 is activated by exposure to lipopolysaccharides derived from the outer membrane of Gram negative ... -
Discovery of Compound A : a selective activator of the glucocorticoid receptor with anti-inflammatory and anti-cancer activity
(Impact Journals, 2015)Glucocorticoids are among the most effective anti-inflammatory drugs, and are widely used for cancer therapy. Unfortunately, chronic treatment with glucocorticoids results in multiple side effects. Thus, there was an ... -
Disease- and treatment-associated acquired glucocorticoid resistance
(BioScientifica, 2018-10-11)ENGLISH ABSTRACT: The development of resistance to glucocorticoids (GCs) in therapeutic regimens poses a major threat. Generally, GC resistance is congenital or acquired over time as a result of disease progression, prolonged ...
