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    Browsing Research Articles (Biochemistry) by Title

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    Now showing items 1-20 of 89

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        11-ketotestosterone and 11-ketodihydrotestosterone in castration resistant prostate cancer : potent androgens which can no longer be ignored 

        Pretorius, Elzette; Africander, Donita J.; Vlok, Mare; Perkins, Meghan S.; Quanson, Jonathan; Storbeck, Karl-Heinz (Public Library of Science, 2016)
        Dihydrotestosterone (DHT) is regarded as the most potent natural androgen and is implicated in the development and progression of castration resistant prostate cancer (CRPC). Under castrate conditions, DHT is produced from ...
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        11β-Hydroxyandrostenedione returns to the steroid arena : biosynthesis, metabolism and function 

        Bloem, Liezl M.; Storbeck, Karl-Heinz; Schloms, Lindie; Swart, Amanda C. (MDPI, 2013-10)
        The biological significance of 11β-hydroxyandrostenedione (11OHA4) has eluded researchers for the past six decades. It is now known that 11OHA4 is biosynthesized in the androgen arm of the adrenal steroidogenesis pathway ...
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        A fully dissociated compound of plant origin for inflammatory gene repression 

        De Bosscher, Karolien; Van den Berghe, Wim; Beck, Ilse M. E.; Van Molle, Wim; Hennuyer, Nathalie; Hapgood, Janet; Liber, Claude; Staels, Bart; Louw, Ann; Haegeman, Guy (PNAS, 2005-11)
        The identification of selective glucocorticoid receptor (GR) modifiers, which separate transactivation and transrepression properties, represents an important research goal for steroid pharmacology. Although the gene-activating ...
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        Abrogation of glucocorticoid receptor dimerization correlates with dissociated glucocorticoid behavior of compound A 

        Robertson, Steven; Allie-Reid, Fatima; Vanden Berghe, Wim; Visser, Koch; Binder, Anke; Africander, Donita; Vismer, Michael; De Bosscher, Karolien; Hapgood, Janet; Haegeman, Guy; Louw, Ann (HighWire Press, 2010-03)
        Compound A (CpdA), a dissociated glucocorticoid receptor modulator, decreases corticosteroid-binding globulin (CBG), adrenocorticotropic hormone (ACTH), and luteneinizing hormone levels in rats. Whether this is due to ...
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        Acetyl-4′-phosphopantetheine is stable in serum and prevents phenotypes induced by pantothenate kinase deficiency 

        Di Meo, Ivano; Colombelli, Cristina; Srinivasan, Balaji; De Villiers, Marianne; Hamada, Jeffrey; Jeong, Suh Y.; Fox, Rachel; Woltjer, Randall L.; Tepper, Pieter G.; Lahaye, Liza L.; Rizzetto, Emanuela; Harrs, Clara H.; De Boer, Theo; Van der Zwaag, Marianne; Jenko, Branko; Cusak, Alen; Pahor, Jerca; Kosec, Gregor; Grzeschik, Nicola A.; Hayflick, Susan J.; Tiranti, Valeria; Sibon, Ody C. M. (Nature Research, 2017-09-12)
        Coenzyme A is an essential metabolite known for its central role in over one hundred cellular metabolic reactions. In cells, Coenzyme A is synthesized de novo in five enzymatic steps with vitamin B5 as the starting metabolite, ...
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        Anti-inflammatory effects of Aspalathus linearis and Cyclopia spp. extracts in a UVB/keratinocyte (HaCaT) model utilising interleukin-1α accumulation as biomarker 

        Magcwebeba, Tandeka; Swart, Pieter; Swanevelder, Sonja; Joubert, Elizabeth; Gelderblom, Wentzel (MDPI, 2016-10-02)
        Ultraviolet B (UVB) radiation is one of the major predisposing risk factors of skin cancer. The anticancer and photoprotective effects of unoxidized rooibos (Aspalathus linearis) and honeybush (Cyclopia) herbal teas, ...
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        Antimikrobiese nanovesels vir waterbehandeling : poli(vinielalkohol)- en poli(akrielonitriel)- nanovesels met silwer-nanopartikels 

        Du Plessis, Danielle; Botes, Marelize; Dicks, Leon Milner Theodore, 1961-; Cloete, Thomas Eugene (LitNet, 2012)
        Daar moet verbeter word op bestaande watersuiweringsmetodes ten einde mikrobiologies veilige en bekostigbare drinkwater te verskaf. Nanovesels word reeds gebruik in waterfiltrasiesisteme en nanofiltrasie mag selfs as ’n ...
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        The biodiversity hotspot as evolutionary hot-bed : spectacular radiation of Erica in the Cape Floristic Region 

        Pirie, M. D.; Oliver, E. G. H.; De Kuppler, A. Mugrabi; Gehrke, B.; Le Maitre, N. C.; Kandziora, M.; Bellstedt, D. U. (BioMed Central, 2016-09-17)
        Background: The disproportionate species richness of the world’s biodiversity hotspots could be explained by low extinction (the evolutionary “museum”) and/or high speciation (the “hot-bed”) models. We test these models ...
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        The carbon switch at the level of pyruvate and phosphoenolpyruvate in sulfolobus solfataricus P2 

        Haferkamp, Patrick; Tjaden, Britta; Shen, Lu; Brasen, Christopher; Kouril, Theresa; Siebers, Bettina (Frontiers Media, 2019-04-12)
        Sulfolobus solfataricus P2 grows on different carbohydrates as well as alcohols, peptides and amino acids. Carbohydrates such as D-glucose or D-galactose are degraded via the modified, branched Entner–Doudoroff (ED) pathway ...
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        Chemoprevention of LA7-induced mammary tumor growth by SM6Met, a well-characterized cyclopia extract 

        Oyenihi, Omolola R.; Krygsman, Annadie; Verhoog, Nicolette; De Beer, Dalene; Saayman, Michael J.; Mouton, Thys M.; Louw, Ann (Frontiers, 2018)
        Breast cancer (BC) is the leading cause of cancer-related deaths in women. Chemoprevention of BC by using plant extracts is gaining attention. SM6Met, a wellcharacterized extract of Cyclopia subternata with reported ...
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        Complex stability and dynamic subunit interchange modulates the disparate activities of the yeast moonlighting proteins Hal3 and Vhs3 

        Abrie, J. Albert; Molero, Cristina; Arino, Joaquin; Strauss, Erick (Springer Nature, 2015-10)
        Saccharomyces cerevisiae Hal3 and Vhs3 are moonlighting proteins, acting both as inhibitors of the serine/threonine protein phosphatase Ppz1 and as subunits (together with Cab3) of the unique heterotrimeric phosphopant ...
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        Conservation implications of avian malaria exposure for African penguins during rehabilitation 

        Botes, Annelise; Thiart, Hanlie; Parsons, Nola J.; Bellstedt, Dirk U. (Academy of Science of South Africa, 2017-02-15)
        ENGLISH ABSTRACT: The African penguin (Spheniscus demersus) is the only penguin species that breeds on the African continent and it is currently classified as endangered. Its conservation is assisted by the Southern ...
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        Consistent phenological shifts in the making of a biodiversity hotspot : the Cape flora 

        Warren, Ben H.; Bakker, Freek T.; Bellstedt, Dirk U.; Bytebier, Benny; Claszen-Bockhoff, Regine; Dreyer, Leanne L.; Edwards, Dawn; Forest, Felix; Galley, Chloe; Hardy, Christopher R.; Linder, H. Peter; Muasya, A. Muthama; Mummenhoff, Klaus; Oberlander, Kenneth C.; Quint, Marcus; Richardson, James E.; Savolainen, Vincent; Schrire, Brian D.; Van der Niet, Timotheus; Verboom, G. Anthony; Yesson, Christopher; Hawkins, Julie A. (BioMed Central, 2011-02)
        ABSTRACT: Background: The best documented survival responses of organisms to past climate change on short (glacial-interglacial) timescales are distributional shifts. Despite ample evidence on such timescales for local ...
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        Cyclopia extracts act as ERα antagonists and ERβ agonists, in vitro and in vivo 

        Visser, Koch; Mortimer, Morne; Louw, Ann (Public Library of Science (PLOS), 2013-11)
        Hormone replacement therapy associated risks, and the concomitant reluctance of usage, has instigated the search for new generations of estrogen analogues that would maintain estrogen benefits without associated ...
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        Data comparing the separation and elution of vitamin D metabolites on an ultra performance supercritical fluid chromatography tandem-mass spectrometer (UPSFC-MS/MS) compared to liquid chromatography (LC) and data presenting approaches to UPSFC method optimization 

        Jenkinson, Carl; Taylor, Angela E.; Storbeck, Karl-Heinz; Hewison, Martin (Elsevier, 2018)
        The data presented is related to the research article "Analysis of multiple vitamin D metabolites by ultra performance supercritical fluid chromatography-tandem mass spectrometry (UPSFC-MS/MS)" (Jenkinson et al., 2018) ...
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        Degradation of proteins and starch by combined immobilization of protease, α-amylase and β-galactosidase on a single electrospun nanofibrous membrane 

        Cloete, William J.; Hayward, Stefan; Swart, Pieter; Klumperman, Bert (MDPI, 2019-01-31)
        Two commercially available enzymes, Dextrozyme (α-amylase) and Esperase (protease), were covalently immobilized on non-woven electrospun poly(styrene-co-maleic anhydride) nanofiber mats with partial retention of their ...
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        Degradation of synthetic xylan effluent using a membrane bioreactor 

        Edward, V. A.; Pillay, V. L.; Swart, P.; Jacobs, E.; Singh, S. (Academy of Science for South Africa, 2003)
        We have built a novel membrane bioreactor for the degradation of synthetic xylan effluent. The reactor contains 30 internally skinned polysulphone membranes as an immobilization matrix for xylanase, the degrading agent, ...
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        Delving deeper : relating the behaviour of a metabolic system to the properties of its components using symbolic metabolic control analysis 

        Christensen, Carl D.; Hofmeyr, Jan-Hendrik S.; Rohwer, Johann M. (Public Library of Science, 2018-11-28)
        High-level behaviour of metabolic systems results from the properties of, and interactions between, numerous molecular components. Reaching a complete understanding of metabolic behaviour based on the system’s components ...
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        Determining enzyme kinetics for systems biology with nuclear magnetic resonance spectroscopy 

        Eicher, Johann J.; Snoep, Jacky L.; Rohwer, Johann M. (MDPI, 2012)
        Enzyme kinetics for systems biology should ideally yield information about the enzyme’s activity under in vivo conditions, including such reaction features as substrate cooperativity, reversibility and allostery, and be ...
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        Detoxification of the fumonisin mycotoxins in maize : an enzymatic approach 

        Alberts, Johanna; Schatzmayr, Gerd; Moll, Wulf-Dieter; Davids, Ibtisaam; Rheeder, John; Burger, Hester-Mari; Shephard, Gordon; Gelderblom, Wentzel (MDPI, 2019-09-10)
        Enzymatic detoxification has become a promising approach for control of mycotoxins postharvest in grains through modification of chemical structures determining their toxicity. In the present study fumonisin esterase FumD ...

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