• Strategies and opportunities for promoting bioinformatics in Zimbabwe 

      Shoko, Ryman; Manasa, Justen; Maphosa, Mcebisi; Mbanga, Joshua; Mudziwapasi, Reagan; Nembaware, Victoria; Sanyika, Walter T.; Tinago, Tawanda; Chikwambi, Zedias; Mawere, Cephas; Matimba, Alice; Mugumbate, Grace; Mufandaedza, Jonathan; Mulder, Nicola; Patterton, Hugh (Public Library of Science, 2018-11-29)
      Introduction: The increasing applications of advanced technologies in life sciences are fueling the growth of data from genome sequencing, functional genomics experiments, and macromolecular structure determination. ...
    • Systems biology of the modified branched Entner-Doudoroff pathway in Sulfolobus solfataricus 

      Figueiredo, Ana Sofia; Kouril, Theresa; Esser, Dominik; Haferkamp, Patrick; Wieloch, Patricia; Schomburg, Dietmar; Ruoff, Peter; Siebers, Bettina; Schaber, Jorg (Public Library of Science, 2017-07-10)
      Sulfolobus solfataricus is a thermoacidophilic Archaeon that thrives in terrestrial hot springs (solfatares) with optimal growth at 80°C and pH 2–4. It catabolizes specific carbon sources, such as D-glucose, to pyruvate ...
    • Targeted NGS for species level phylogenomics : "made to measure'' or "one size fits all''? 

      Kadlec, Malvina; Bellstedt, Dirk U.; Le Maitre, Nicholas C.; Pirie, Michael D. (PeerJ, 2017)
      Targeted high-throughput sequencing using hybrid-enrichment offers a promising source of data for inferring multiple, meaningfully resolved, independent gene trees suitable to address challenging phylogenetic problems ...
    • Targeting pathogen metabolism without collateral damage to the host 

      Haanstra, Jurgen R.; Gerding, Albert; Dolga, Amalia M.; Sorgdrager, Freek J. H.; Buist-Homan, Manon; Du Toit, Francois; Faber, Klaas Nico; Holzhutter, Hermann-Georg; Szoor, Balazs; Matthews, Keith R.; Snoep, Jacky L.; Westerhoff, Hans V.; Bakker, Barbara M. (Nature Research, 2017-01-13)
      The development of drugs that can inactivate disease-causing cells (e.g. cancer cells or parasites) without causing collateral damage to healthy or to host cells is complicated by the fact that many proteins are very similar ...
    • Tracing regulatory routes in metabolism using generalised supply-demand analysis 

      Christensen, Carl D.; Hofmeyr, Jan-Hendrik S.; Rohwer, Johann M. (BioMed Central, 2015-12)
      Background: Generalised supply-demand analysis is a conceptual framework that views metabolism as a molecular economy. Metabolic pathways are partitioned into so-called supply and demand blocks that produce and consume ...
    • Using bark as a heat insulation material 

      Kain, Gunther; Barbu, Marius Catalin; Hinterreiter, Stefan; Richter, Klaus; Petutschnigg, Alexander (North Carolina State University, College of Natural Resources, 2013)
      Spruce bark particles were used as an insulation fill material for the thermal insulation of a timber frame wall which was subjected to a simulated winter temperature difference between indoor and outdoor climate. The ...
    • Well-positioned nucleosomes punctuate polycistronic pol II transcription units and flank silent VSG gene arrays in Trypanosoma brucei 

      Maree, Johannes P.; Povelones, Megan L.; Clark, David J.; Rudenko, Gloria; Patterton, Hugh-George (BioMed Central, 2017)
      Background The compaction of DNA in chromatin in eukaryotes allowed the expansion of genome size and coincided with significant evolutionary diversification. However, chromatin generally represses DNA function, and ...
    • What goes around comes around-a comparative study of the influence of chemical modifications on the antimicrobial properties of small cyclic peptides 

      Scheinpflug, Kathi; Nikolenko, Heike; Komarov, Igor V.; Rautenbach, Marina; Dathe, Margitta (MDPI, 2013)
      Tryptophan and arginine-rich cyclic hexapeptides of the type cyclo-RRRWFW combine high antibacterial activity with rapid cell killing kinetics, but show low toxicity in human cell lines. The peptides fulfil the structural ...
    • Workflow for data analysis in experimental and computational systems biology : using Python as glue 

      Badenhorst, Melinda; Barry, Christopher J.; Swanepoel, Christiaan J.; Van Staden, Charles Theo; Wissing, Julian; Rohwer, Johann M. (MDPI, 2019-07-18)
      ENGLISH ABSTRACT: Bottom-up systems biology entails the construction of kinetic models of cellular pathways by collecting kinetic information on the pathway components (e.g., enzymes) and collating this into a kinetic ...