Browsing Research Articles (Biochemistry) by Title
Now showing items 65-80 of 80
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Reproducible computational biology experiments with SED-ML -The Simulation Experiment Description Markup Language
(BioMed Central, 2011-12)Background: The increasing use of computational simulation experiments to inform modern biological research creates new challenges to annotate, archive, share and reproduce such experiments. The recently published Minimum ... -
Rooibos flavonoids inhibit the activity of key adrenal steroidogenic enzymes, modulating steroid hormone levels in H295R cells
(MDPI, 2014-03)Major rooibos flavonoids—dihydrochalcones, aspalathin and nothofagin, flavones—orientin and vitexin, and a flavonol, rutin, were investigated to determine their influence on the activity of adrenal steroidogenic enzymes, ... -
Salsola tuberculatiformis botschantzev and an aziridine precursor analog mediate the in vivo increase in free corticosterone and decrease in corticosteroid-binding globulin in female wistar rats
(The Endocrine Society, 1999-05)Salsola tuberculatiformis Botschantzev causes prolonged gestation in sheep and contraception in rats. An active fraction isolated from the shrub, containing a highly labile hydoxyphenyl aziridine or precursor, and a ... -
Screening of four Cyclopia (honeybush) species for putative phyto-oestrogenic activity by oestrogen receptor binding assays
(AOSIS OpenJournals, 2007)Phyto-oestrogens mediate an oestrogenic effect through binding to the oestrogen receptor (ER) subtypes, ERα and ERβ. Four commercially available Cyclopia (honeybush) species - C. intermedia, C. subternata, C. genistoides ... -
SEEK : a systems biology data and model management platform
(BioMed Central, 2015-07-11)Background: Systems biology research typically involves the integration and analysis of heterogeneous data types in order to model and predict biological processes. Researchers therefore require tools and resources to ... -
Simultaneous quantification of coenzyme A and its salvage pathway intermediates in in vitro and whole cell-sourced samples
(Royal Society of Chemistry, 2018-11-23)We report a method for the simultaneous quantification of the essential metabolic cofactor coenzyme A (CoA) and its thiol-bearing precursors—including 4′-phosphopantetheine, which was recently shown to play a potentially ... -
South African herbal teas : Aspalathus linearis, Cyclopia spp. and Athrixia phylicoides - a review
(Elsevier, 2008-10)Rooibos (Aspalathus linearis (Brum.f) Dahlg.) and honeybush (Cyclopia Vent. species) are popular indigenous South African herbal teas enjoyed for their taste and aroma. Traditional medicinal uses of rooibos in South ... -
Strategies and opportunities for promoting bioinformatics in Zimbabwe
(Public Library of Science, 2018-11-29)Introduction: The increasing applications of advanced technologies in life sciences are fueling the growth of data from genome sequencing, functional genomics experiments, and macromolecular structure determination. ... -
Systems biology of the modified branched Entner-Doudoroff pathway in Sulfolobus solfataricus
(Public Library of Science, 2017-07-10)Sulfolobus solfataricus is a thermoacidophilic Archaeon that thrives in terrestrial hot springs (solfatares) with optimal growth at 80°C and pH 2–4. It catabolizes specific carbon sources, such as D-glucose, to pyruvate ... -
Targeted NGS for species level phylogenomics : "made to measure'' or "one size fits all''?
(PeerJ, 2017)Targeted high-throughput sequencing using hybrid-enrichment offers a promising source of data for inferring multiple, meaningfully resolved, independent gene trees suitable to address challenging phylogenetic problems ... -
Targeting pathogen metabolism without collateral damage to the host
(Nature Research, 2017-01-13)The development of drugs that can inactivate disease-causing cells (e.g. cancer cells or parasites) without causing collateral damage to healthy or to host cells is complicated by the fact that many proteins are very similar ... -
Tracing regulatory routes in metabolism using generalised supply-demand analysis
(BioMed Central, 2015-12)Background: Generalised supply-demand analysis is a conceptual framework that views metabolism as a molecular economy. Metabolic pathways are partitioned into so-called supply and demand blocks that produce and consume ... -
Using bark as a heat insulation material
(North Carolina State University, College of Natural Resources, 2013)Spruce bark particles were used as an insulation fill material for the thermal insulation of a timber frame wall which was subjected to a simulated winter temperature difference between indoor and outdoor climate. The ... -
Well-positioned nucleosomes punctuate polycistronic pol II transcription units and flank silent VSG gene arrays in Trypanosoma brucei
(BioMed Central, 2017)Background The compaction of DNA in chromatin in eukaryotes allowed the expansion of genome size and coincided with significant evolutionary diversification. However, chromatin generally represses DNA function, and ... -
What goes around comes around-a comparative study of the influence of chemical modifications on the antimicrobial properties of small cyclic peptides
(MDPI, 2013)Tryptophan and arginine-rich cyclic hexapeptides of the type cyclo-RRRWFW combine high antibacterial activity with rapid cell killing kinetics, but show low toxicity in human cell lines. The peptides fulfil the structural ... -
Workflow for data analysis in experimental and computational systems biology : using Python as glue
(MDPI, 2019-07-18)ENGLISH ABSTRACT: Bottom-up systems biology entails the construction of kinetic models of cellular pathways by collecting kinetic information on the pathway components (e.g., enzymes) and collating this into a kinetic ...
