Browsing Research Articles (Biochemistry) by Title
Now showing items 54-73 of 81
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Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues
(Public Library of Science, 2018-04-03)The malaria-causing blood stage of Plasmodium falciparum requires extracellular pantothenate for proliferation. The parasite converts pantothenate into coenzyme A (CoA) via five enzymes, the first being a pantothenate ... -
New and interesting orchid records for Tanzania
(BioOne, 2004-01)The orchid taxa Brachycorythis ovata subsp. schweinfurthii, Habenaria arianae and Habenaria disparilis are newly recorded for Tanzania, while Brachycorythis congoensis is newly recorded for the floral region T7. A stable, ... -
A new species of Streptocarpus (Gesneriaceae) endemic to Madagascar
(Museum Nationale d'Histoire Naturelle Paris, 2005-03)A new species of Streptocarpus (S. lanatus MacMaster) is described from central Madagascar. Material referable to this new taxon was previously assigned to S. ibityensis Humbert, from which it can be distinguished by its ... -
Not all progestins are the same : implications for usage
(Elsevier, 2004-11)Recent clinical evidence showing unexpected side-effects of progestins used in contraception and hormone replacement therapy has highlighted the importance of choice of synthetic progestin. The molecularmechanisms of ... -
Novel role for receptor dimerization in post-translational processing and turnover of the GRα
(Nature, 2018)Glucocorticoids (GCs), acting via the glucocorticoid receptor (GRα), remain the mainstay therapeutic choice for the treatment of inflammation. However, chronic GC use, aside from generating undesirable side-effects, ... -
Pantothenamides are potent, on-target inhibitors of plasmodium falciparum growth when serum pantetheinase is inactivated
(PLoS, 2013-02)Growth of the virulent human malaria parasite Plasmodium falciparum is dependent on an extracellular supply of pantothenate (vitamin B5) and is susceptible to inhibition by pantothenate analogues that hinder pantothenate ... -
Patterns of variation and chemosystematic significance of phenolic compounds in the genus cyclopia (fabaceae, podalyrieae)
(MDPI, 2019)ENGLISH ABSTRACT: As a contribution towards a better understanding of phenolic variation in the genus Cyclopia (honeybush tea), a collection of 82 samples from 15 of the 23 known species was analysed using liquid-chromat ... -
The peculiar glycolytic pathway in hyperthermophylic archaea : understanding its whims by experimentation in silico
(MDPI, 2017)Mathematical models are key to systems biology where they typically describe the topology and dynamics of biological networks, listing biochemical entities and their relationships with one another. Some (hyper)thermophilic ... -
Phylogeography and molecular evolution of potato virus Y
(Public Library of Science, 2012-05-24)Potato virus Y (PVY) is an important plant pathogen, whose host range includes economically important crops such as potato, tobacco, tomato, and pepper. PVY presents three main strains (PVY O, PVY ... -
Phytoestrogenic potential of Cyclopia extracts and polyphenols
(Georg Thieme Verlag, 2013-05)Cyclopia Vent. species, commonly known as honeybush, are endemic to Southern Africa. The plant is traditionally used as an herbal tea but several health benefits have recently been recorded. This minireview presents an ... -
Preliminary investigations into the use of DNA vaccines to elicit protective immune responses against the ostrich mycoplasma Ms01
(Stellenbosch : Stellenbosch University, 2012-03)ENGLISH ABSTRACT: Mycoplasmas are evolutionarily advanced prokaryotes which have acquired the elite status of “next generation” bacterial pathogens and necessitate new paradigms in completely understanding their ... -
The recent recombinant evolution of a major crop pathogen, potato virus Y
(PLOS, 2012-11-30)Potato virus Y (PVY) is a major agricultural disease that reduces crop yields worldwide. Different strains of PVY are associated with differing degrees of pathogenicity, of which the most common and economically important ... -
Reproducible computational biology experiments with SED-ML -The Simulation Experiment Description Markup Language
(BioMed Central, 2011-12)Background: The increasing use of computational simulation experiments to inform modern biological research creates new challenges to annotate, archive, share and reproduce such experiments. The recently published Minimum ... -
Rooibos flavonoids inhibit the activity of key adrenal steroidogenic enzymes, modulating steroid hormone levels in H295R cells
(MDPI, 2014-03)Major rooibos flavonoids—dihydrochalcones, aspalathin and nothofagin, flavones—orientin and vitexin, and a flavonol, rutin, were investigated to determine their influence on the activity of adrenal steroidogenic enzymes, ... -
Salsola tuberculatiformis botschantzev and an aziridine precursor analog mediate the in vivo increase in free corticosterone and decrease in corticosteroid-binding globulin in female wistar rats
(The Endocrine Society, 1999-05)Salsola tuberculatiformis Botschantzev causes prolonged gestation in sheep and contraception in rats. An active fraction isolated from the shrub, containing a highly labile hydoxyphenyl aziridine or precursor, and a ... -
Screening of four Cyclopia (honeybush) species for putative phyto-oestrogenic activity by oestrogen receptor binding assays
(AOSIS OpenJournals, 2007)Phyto-oestrogens mediate an oestrogenic effect through binding to the oestrogen receptor (ER) subtypes, ERα and ERβ. Four commercially available Cyclopia (honeybush) species - C. intermedia, C. subternata, C. genistoides ... -
SEEK : a systems biology data and model management platform
(BioMed Central, 2015-07-11)Background: Systems biology research typically involves the integration and analysis of heterogeneous data types in order to model and predict biological processes. Researchers therefore require tools and resources to ... -
Simultaneous quantification of coenzyme A and its salvage pathway intermediates in in vitro and whole cell-sourced samples
(Royal Society of Chemistry, 2018-11-23)We report a method for the simultaneous quantification of the essential metabolic cofactor coenzyme A (CoA) and its thiol-bearing precursors—including 4′-phosphopantetheine, which was recently shown to play a potentially ... -
South African herbal teas : Aspalathus linearis, Cyclopia spp. and Athrixia phylicoides - a review
(Elsevier, 2008-10)Rooibos (Aspalathus linearis (Brum.f) Dahlg.) and honeybush (Cyclopia Vent. species) are popular indigenous South African herbal teas enjoyed for their taste and aroma. Traditional medicinal uses of rooibos in South ... -
Strategies and opportunities for promoting bioinformatics in Zimbabwe
(Public Library of Science, 2018-11-29)Introduction: The increasing applications of advanced technologies in life sciences are fueling the growth of data from genome sequencing, functional genomics experiments, and macromolecular structure determination. ...
