Browsing Research Articles (Biochemistry) by Title
Now showing items 22-41 of 81
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Disease- and treatment-associated acquired glucocorticoid resistance
(BioScientifica, 2018-10-11)ENGLISH ABSTRACT: The development of resistance to glucocorticoids (GCs) in therapeutic regimens poses a major threat. Generally, GC resistance is congenital or acquired over time as a result of disease progression, prolonged ... -
Divide and conquer may not be the optimal approach to retain the desirable estrogenic attributes of the cyclopia nutraceutical extract, SM6Met
(Public Library of Science, 2015)The genus Cyclopia, an indigenous South African fynbos plant used to prepare honeybush tea, contains phytoestrogenic compounds. An extract from C. subternata, SM6Met, displays three desirable estrogenic attributes for ... -
DNA vaccines against mycoplasma elicit humoral immune responses in ostriches
(Frontiers Media, 2019-05-14)In ostriches, the population densities resulting from intensive rearing increases susceptibility to pathogens such as mycoplasmas. In addition to good management practices, vaccination offers an attractive alternative ... -
Evaluation of production and reproduction of three South African Angora goat CYP17 genotypes
(South African Society for Animal Science, 2017-06-05)Two CYP17 genes, located on different loci and expressing enzymes with significantly different activities, have been identified in the South African Angora goat population. Three unique genotypes (named He, Hu, and Ho), ... -
Evaluation of the phytoestrogenic activity of Cyclopia genistoides (honeybush) methanol extracts and relevant polyphenols
(American Chemical Society, 2007-04)Unfermented C. genistoides methanol extracts of different harvestings and selected polyphenols were evaluated for phytoestrogenic activity by comparing binding to both ER subtypes, transactivation of an ERE-containing ... -
The evolution of standards and data management practices in systems biology
(EMBO, 2015-12)Systems biology involves the integration of multiple heterogeneous data sets, in order to model and predict biological processes. The domain's interdisciplinary nature requires data, models and other research assets to be ... -
Exploration of the hypothalamic-pituitary-adrenal axis to improve animal welfare by mean of genetic selection : lessons from the South African merino
(MDPI, 2013)It is a difficult task to improve animal production by means of genetic selection, if the environment does not allow full expression of the animal’s genetic potential. This concept may well be the future for animal welfare, ... -
Extinction risk and diversification are linked in a plant biodiversity hotspot
(Public Library of Science, 2011-05)It is widely recognized that we are entering an extinction event on a scale approaching the mass extinctions seen in the fossil record. Present-day rates of extinction are estimated to be several orders of magnitude greater ... -
FAIRDOMHub : a repository and collaboration environment for sharing systems biology research
(Oxford University Press on behalf of Nucleic Acids Research, 2017)The FAIRDOMHub is a repository for publishing FAIR (Findable, Accessible, Interoperable and Reusable) Data, Operating procedures and Models (https://fairdomhub.org/) for the Systems Biology community. It is a web-accessible ... -
Falsely elevated plasma testosterone concentrations in neonates : importance of LC-MS/ MS measurements
(De Gruyter, 2018-01)In newborns with atypical genitalia, suspicious for a disorder of sex development (DSD), measurement of testosterone is an essential part in the diagnostic workup. Previously, direct testosterone immunoassays have proven ... -
Filovirus disease outbreaks : a chronological overview
(SAGE, 2019)Filoviruses cause outbreaks which lead to high fatality in humans and non-human primates, thus tagging them as major threats to public health and species conservation. In this review, we give account of index cases responsible ... -
Floral color, anthocyanin synthesis gene expression and control in Cape Erica species
(Frontiers Media, 2019-11-28)Introduction: The Cape Floristic Region (CFR) is a biodiversity hotspot, recognized globally for its unusually high levels of endemism. The origins of this biodiversity are a long-standing topic of research. The largest ... -
Fourth-generation progestins inhibit 3β-hydroxysteroid dehydrogenase type 2 and modulate the biosynthesis of endogenous steroids
(Public Library of Science, 2016-05)Progestins used in contraception and hormone replacement therapy are synthetic compounds designed to mimic the actions of the natural hormone progesterone and are classed into four consecutive generations. The biological ... -
Genetic susceptibility to tuberculosis in Africans : a genome-wide scan
(National Academy of Sciences, 2000)Human genetic variation is an important determinant of the outcome of infection with Mycobacterium tuberculosis. We have conducted a two-stage genome-wide linkage study to search for regions of the human genome containing ... -
Glucocorticoid receptor concentration and the ability to dimerize influence nuclear translocation and distribution
(Elsevier, 2013-02)Glucocorticoid receptor (GR) concentrations and the ability of the GR to dimerize are factors which influence sensitivity to glucocorticoids. Upon glucocorticoid binding, the GR is actively transported into the nucleus, ... -
The glutaredoxin mono- and di-thiol mechanisms for deglutathionylation are functionally equivalent : implications for redox systems biology
(Portland Press, 2015)Glutathionylation plays a central role in cellular redox regulation and anti-oxidative defence. Grx (Glutaredoxins) are primarily responsible for reversing glutathionylation and their activity therefore affects a range ... -
GR dimerization and the impact of GR dimerization on GR protein stability and half-life
(Frontiers Media, 2019-07-17)Pharmacologically, glucocorticoids, which mediate their effects via the glucocorticoid receptor (GR), are a most effective therapy for inflammatory diseases despite the fact that chronic use causes side-effects and ... -
Identifiers for the 21st century : how to design, provision, and reuse persistent identifiers to maximize utility and impact of life science data
(Public Library of Science, 2017-06-29)In many disciplines, data are highly decentralized across thousands of online databases (repositories, registries, and knowledgebases). Wringing value from such databases depends on the discipline of data science and on ... -
IMA Genome-F 11: Draft genome sequences of Fusarium xylarioides, Teratosphaeria gauchensis and T. zuluensis and genome annotation for Ceratocystis fimbriata
(BMC (part of Springer Nature), 2019-09-13)ENGLISH ABSTRACT: Draft genomes of the fungal species Fusarium xylarioides, Teratosphaeria gauchensis and T. zuluensis are presented. In addition an annotation of the genome of Ceratocystis fimbriata is presented. Overall ... -
Impact of glucocorticoid receptor density on ligand- independent dimerization, cooperative ligand-binding and basal priming of transactivation : a cell culture model
(Public Library of Science -- PLoS, 2013-05)Glucocorticoid receptor (GR) levels vary between tissues and individuals and are altered by physiological and pharmacological effectors. However, the effects and implications of differences in GR concentration have not ...
