Browsing Research Articles (Biochemistry) by Title
Now showing items 49-68 of 80
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A metabolomics-guided exploration of the phytochemical constituents of Vernonia fastigiata with the aid of pressurized hot water extraction and liquid chromatography-mass spectrometry
(MDPI, 2017)Vernonia fastigiata is a multi-purpose nutraceutical plant with interesting biological properties. However, very little is known about its phytochemical composition and, thus the need for its phytochemical characterization. ... -
Minimum information about a simulation experiment (MIASE)
(PLOS, 2011-04)Reproducibility of experiments is a basic requirement for science. Minimum Information (MI) guidelines have proved a helpful means of enabling reuse of existing work in modern biology. The Minimum Information Required in ... -
The multifaceted antibacterial mechanisms of the pioneering peptide antibiotics tyrocidine and gramicidin S
(American Society for Microbiology, 2018-10-09)ENGLISH ABSTRACT: Cyclic β-sheet decapeptides from the tyrocidine group and the homologous gramicidin S were the first commercially used antibiotics, yet it remains unclear exactly how they kill bacteria. We investigated ... -
Mutations at the hydrophobic core affect Hal3 trimer stability, reducing its Ppz1 inhibitory capacity but not its PPCDC moonlighting function
(Nature Research, 2018-10-02)S. cerevisiae Hal3 (ScHal3) is a moonlighting protein that, is in its monomeric state, regulates the Ser/Thr protein phosphatase Ppz1, but also joins ScCab3 (and in some instances the Hal3 paralog Vhs3) to form an unusual ... -
Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues
(Public Library of Science, 2018-04-03)The malaria-causing blood stage of Plasmodium falciparum requires extracellular pantothenate for proliferation. The parasite converts pantothenate into coenzyme A (CoA) via five enzymes, the first being a pantothenate ... -
New and interesting orchid records for Tanzania
(BioOne, 2004-01)The orchid taxa Brachycorythis ovata subsp. schweinfurthii, Habenaria arianae and Habenaria disparilis are newly recorded for Tanzania, while Brachycorythis congoensis is newly recorded for the floral region T7. A stable, ... -
A new species of Streptocarpus (Gesneriaceae) endemic to Madagascar
(Museum Nationale d'Histoire Naturelle Paris, 2005-03)A new species of Streptocarpus (S. lanatus MacMaster) is described from central Madagascar. Material referable to this new taxon was previously assigned to S. ibityensis Humbert, from which it can be distinguished by its ... -
Not all progestins are the same : implications for usage
(Elsevier, 2004-11)Recent clinical evidence showing unexpected side-effects of progestins used in contraception and hormone replacement therapy has highlighted the importance of choice of synthetic progestin. The molecularmechanisms of ... -
Novel role for receptor dimerization in post-translational processing and turnover of the GRα
(Nature, 2018)Glucocorticoids (GCs), acting via the glucocorticoid receptor (GRα), remain the mainstay therapeutic choice for the treatment of inflammation. However, chronic GC use, aside from generating undesirable side-effects, ... -
Pantothenamides are potent, on-target inhibitors of plasmodium falciparum growth when serum pantetheinase is inactivated
(PLoS, 2013-02)Growth of the virulent human malaria parasite Plasmodium falciparum is dependent on an extracellular supply of pantothenate (vitamin B5) and is susceptible to inhibition by pantothenate analogues that hinder pantothenate ... -
Patterns of variation and chemosystematic significance of phenolic compounds in the genus cyclopia (fabaceae, podalyrieae)
(MDPI, 2019)ENGLISH ABSTRACT: As a contribution towards a better understanding of phenolic variation in the genus Cyclopia (honeybush tea), a collection of 82 samples from 15 of the 23 known species was analysed using liquid-chromat ... -
The peculiar glycolytic pathway in hyperthermophylic archaea : understanding its whims by experimentation in silico
(MDPI, 2017)Mathematical models are key to systems biology where they typically describe the topology and dynamics of biological networks, listing biochemical entities and their relationships with one another. Some (hyper)thermophilic ... -
Phylogeography and molecular evolution of potato virus Y
(Public Library of Science, 2012-05-24)Potato virus Y (PVY) is an important plant pathogen, whose host range includes economically important crops such as potato, tobacco, tomato, and pepper. PVY presents three main strains (PVY O, PVY ... -
Phytoestrogenic potential of Cyclopia extracts and polyphenols
(Georg Thieme Verlag, 2013-05)Cyclopia Vent. species, commonly known as honeybush, are endemic to Southern Africa. The plant is traditionally used as an herbal tea but several health benefits have recently been recorded. This minireview presents an ... -
Preliminary investigations into the use of DNA vaccines to elicit protective immune responses against the ostrich mycoplasma Ms01
(Stellenbosch : Stellenbosch University, 2012-03)ENGLISH ABSTRACT: Mycoplasmas are evolutionarily advanced prokaryotes which have acquired the elite status of “next generation” bacterial pathogens and necessitate new paradigms in completely understanding their ... -
The recent recombinant evolution of a major crop pathogen, potato virus Y
(PLOS, 2012-11-30)Potato virus Y (PVY) is a major agricultural disease that reduces crop yields worldwide. Different strains of PVY are associated with differing degrees of pathogenicity, of which the most common and economically important ... -
Reproducible computational biology experiments with SED-ML -The Simulation Experiment Description Markup Language
(BioMed Central, 2011-12)Background: The increasing use of computational simulation experiments to inform modern biological research creates new challenges to annotate, archive, share and reproduce such experiments. The recently published Minimum ... -
Rooibos flavonoids inhibit the activity of key adrenal steroidogenic enzymes, modulating steroid hormone levels in H295R cells
(MDPI, 2014-03)Major rooibos flavonoids—dihydrochalcones, aspalathin and nothofagin, flavones—orientin and vitexin, and a flavonol, rutin, were investigated to determine their influence on the activity of adrenal steroidogenic enzymes, ... -
Salsola tuberculatiformis botschantzev and an aziridine precursor analog mediate the in vivo increase in free corticosterone and decrease in corticosteroid-binding globulin in female wistar rats
(The Endocrine Society, 1999-05)Salsola tuberculatiformis Botschantzev causes prolonged gestation in sheep and contraception in rats. An active fraction isolated from the shrub, containing a highly labile hydoxyphenyl aziridine or precursor, and a ... -
Screening of four Cyclopia (honeybush) species for putative phyto-oestrogenic activity by oestrogen receptor binding assays
(AOSIS OpenJournals, 2007)Phyto-oestrogens mediate an oestrogenic effect through binding to the oestrogen receptor (ER) subtypes, ERα and ERβ. Four commercially available Cyclopia (honeybush) species - C. intermedia, C. subternata, C. genistoides ...
