Browsing Research Articles (Biochemistry) by Title
Now showing items 29-48 of 80
-
FAIRDOMHub : a repository and collaboration environment for sharing systems biology research
(Oxford University Press on behalf of Nucleic Acids Research, 2017)The FAIRDOMHub is a repository for publishing FAIR (Findable, Accessible, Interoperable and Reusable) Data, Operating procedures and Models (https://fairdomhub.org/) for the Systems Biology community. It is a web-accessible ... -
Falsely elevated plasma testosterone concentrations in neonates : importance of LC-MS/ MS measurements
(De Gruyter, 2018-01)In newborns with atypical genitalia, suspicious for a disorder of sex development (DSD), measurement of testosterone is an essential part in the diagnostic workup. Previously, direct testosterone immunoassays have proven ... -
Filovirus disease outbreaks : a chronological overview
(SAGE, 2019)Filoviruses cause outbreaks which lead to high fatality in humans and non-human primates, thus tagging them as major threats to public health and species conservation. In this review, we give account of index cases responsible ... -
Floral color, anthocyanin synthesis gene expression and control in Cape Erica species
(Frontiers Media, 2019-11-28)Introduction: The Cape Floristic Region (CFR) is a biodiversity hotspot, recognized globally for its unusually high levels of endemism. The origins of this biodiversity are a long-standing topic of research. The largest ... -
Fourth-generation progestins inhibit 3β-hydroxysteroid dehydrogenase type 2 and modulate the biosynthesis of endogenous steroids
(Public Library of Science, 2016-05)Progestins used in contraception and hormone replacement therapy are synthetic compounds designed to mimic the actions of the natural hormone progesterone and are classed into four consecutive generations. The biological ... -
Genetic susceptibility to tuberculosis in Africans : a genome-wide scan
(National Academy of Sciences, 2000)Human genetic variation is an important determinant of the outcome of infection with Mycobacterium tuberculosis. We have conducted a two-stage genome-wide linkage study to search for regions of the human genome containing ... -
Glucocorticoid receptor concentration and the ability to dimerize influence nuclear translocation and distribution
(Elsevier, 2013-02)Glucocorticoid receptor (GR) concentrations and the ability of the GR to dimerize are factors which influence sensitivity to glucocorticoids. Upon glucocorticoid binding, the GR is actively transported into the nucleus, ... -
The glutaredoxin mono- and di-thiol mechanisms for deglutathionylation are functionally equivalent : implications for redox systems biology
(Portland Press, 2015)Glutathionylation plays a central role in cellular redox regulation and anti-oxidative defence. Grx (Glutaredoxins) are primarily responsible for reversing glutathionylation and their activity therefore affects a range ... -
GR dimerization and the impact of GR dimerization on GR protein stability and half-life
(Frontiers Media, 2019-07-17)Pharmacologically, glucocorticoids, which mediate their effects via the glucocorticoid receptor (GR), are a most effective therapy for inflammatory diseases despite the fact that chronic use causes side-effects and ... -
Identifiers for the 21st century : how to design, provision, and reuse persistent identifiers to maximize utility and impact of life science data
(Public Library of Science, 2017-06-29)In many disciplines, data are highly decentralized across thousands of online databases (repositories, registries, and knowledgebases). Wringing value from such databases depends on the discipline of data science and on ... -
IMA Genome-F 11: Draft genome sequences of Fusarium xylarioides, Teratosphaeria gauchensis and T. zuluensis and genome annotation for Ceratocystis fimbriata
(BMC (part of Springer Nature), 2019-09-13)ENGLISH ABSTRACT: Draft genomes of the fungal species Fusarium xylarioides, Teratosphaeria gauchensis and T. zuluensis are presented. In addition an annotation of the genome of Ceratocystis fimbriata is presented. Overall ... -
Impact of glucocorticoid receptor density on ligand- independent dimerization, cooperative ligand-binding and basal priming of transactivation : a cell culture model
(Public Library of Science -- PLoS, 2013-05)Glucocorticoid receptor (GR) levels vary between tissues and individuals and are altered by physiological and pharmacological effectors. However, the effects and implications of differences in GR concentration have not ... -
In vitro chemopreventive properties of green tea, rooibos and honeybush extracts in skin cells
(MDPI, 2016-11-25)The chemopreventive properties of the herbal teas rooibos (Aspalathus linearis) and honeybush (Cyclopia spp.) have been demonstrated on mouse skin in vivo but the underlying mechanisms are not clear. The aim of the current ... -
Inhibition of corticosteroid-binding globulin gene expression by glucocorticoids involves C/EBPβ
(2014-10)Corticosteroid-binding globulin (CBG), a negative acute phase protein produced primarily in the liver, is responsible for the transport of glucocorticoids (GCs). It also modulates the bioavailability of GCs, as only free ... -
Inhibition of cytochrome P450c11 by biogenic amines and an aziridine precursor, 2-(4-acetoxyphenyl_-2-chloro-n-methyl-ethylammonium chloride
(Informa Healthcare, 2000)The interaction of several biogenic amines and Compound A (2-(4-acetoxyphenyl)-2-chloro- N-methyl-ethylammonium chloride), an analogue of the active substance in a HPLC fraction isolated from the shrub, Salsola tuberculatiformis ... -
The injectable-only contraceptive medroxyprogesterone acetate, unlike norethisterone acetate and progesterone, regulates inflammatory genes in endocervical cells via the glucocorticoid receptor
(PLoS, 2014-05-19)Clinical studies suggest that the injectable contraceptive medroxyprogesterone acetate (MPA) increases susceptibility to infections such as HIV-1, unlike the injectable contraceptive norethisterone enanthate (NET-EN). We ... -
Interplay of the inflammatory and stress systems in a hepatic cell line : interactions between glucocorticoid receptor agonists and interleukin-6
(HighWire Press, 2010-11)The liver plays an important role in inflammation and stress by producing the acute phase proteins (APPs) required for resolution of inflammation as well as by delivering systemic glucose, through gluconeogenesis, required ... -
Leaps and bounds : geographical and ecological distance constrained the colonisation of the Afrotemperate by Erica
(BMC (part of Springer Nature), 2019-12-05)Background: The coincidence of long distance dispersal (LDD) and biome shift is assumed to be the result of a multifaceted interplay between geographical distance and ecological suitability of source and sink areas. Here, ... -
The logic of kinetic regulation in the thioredoxin system
(BioMed Central, 2011-01)Abstract: Background: The thioredoxin system consisting of NADP(H), thioredoxin reductase and thioredoxin provides reducing equivalents to a large and diverse array of cellular processes. Despite a great deal of information ... -
Lysosomal disruption during the development of endotoxic shock in the baboon
(Health and Medical Publishing Group (HMPG), 1975-06)Lysosomal disruption with release of lysosomal enzymes has been described in shock. This study was designed to demonstrate the release of lysosomal enzymes in the liver and lung in addition to determining circulating serum ...
