Browsing Research Articles (Biochemistry) by Title
Now showing items 9-28 of 80
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Chemoprevention of LA7-induced mammary tumor growth by SM6Met, a well-characterized cyclopia extract
(Frontiers, 2018)Breast cancer (BC) is the leading cause of cancer-related deaths in women. Chemoprevention of BC by using plant extracts is gaining attention. SM6Met, a wellcharacterized extract of Cyclopia subternata with reported ... -
Complex stability and dynamic subunit interchange modulates the disparate activities of the yeast moonlighting proteins Hal3 and Vhs3
(Springer Nature, 2015-10)Saccharomyces cerevisiae Hal3 and Vhs3 are moonlighting proteins, acting both as inhibitors of the serine/threonine protein phosphatase Ppz1 and as subunits (together with Cab3) of the unique heterotrimeric phosphopant ... -
Conservation implications of avian malaria exposure for African penguins during rehabilitation
(Academy of Science of South Africa, 2017-02-15)ENGLISH ABSTRACT: The African penguin (Spheniscus demersus) is the only penguin species that breeds on the African continent and it is currently classified as endangered. Its conservation is assisted by the Southern ... -
Consistent phenological shifts in the making of a biodiversity hotspot : the Cape flora
(BioMed Central, 2011-02)ABSTRACT: Background: The best documented survival responses of organisms to past climate change on short (glacial-interglacial) timescales are distributional shifts. Despite ample evidence on such timescales for local ... -
Cyclopia extracts act as ERα antagonists and ERβ agonists, in vitro and in vivo
(Public Library of Science (PLOS), 2013-11)Hormone replacement therapy associated risks, and the concomitant reluctance of usage, has instigated the search for new generations of estrogen analogues that would maintain estrogen benefits without associated ... -
Data comparing the separation and elution of vitamin D metabolites on an ultra performance supercritical fluid chromatography tandem-mass spectrometer (UPSFC-MS/MS) compared to liquid chromatography (LC) and data presenting approaches to UPSFC method optimization
(Elsevier, 2018)The data presented is related to the research article "Analysis of multiple vitamin D metabolites by ultra performance supercritical fluid chromatography-tandem mass spectrometry (UPSFC-MS/MS)" (Jenkinson et al., 2018) ... -
Degradation of synthetic xylan effluent using a membrane bioreactor
(Academy of Science for South Africa, 2003)We have built a novel membrane bioreactor for the degradation of synthetic xylan effluent. The reactor contains 30 internally skinned polysulphone membranes as an immobilization matrix for xylanase, the degrading agent, ... -
Delving deeper : relating the behaviour of a metabolic system to the properties of its components using symbolic metabolic control analysis
(Public Library of Science, 2018-11-28)High-level behaviour of metabolic systems results from the properties of, and interactions between, numerous molecular components. Reaching a complete understanding of metabolic behaviour based on the system’s components ... -
Determining enzyme kinetics for systems biology with nuclear magnetic resonance spectroscopy
(MDPI, 2012)Enzyme kinetics for systems biology should ideally yield information about the enzyme’s activity under in vivo conditions, including such reaction features as substrate cooperativity, reversibility and allostery, and be ... -
The development of computational biology in South Africa : successes achieved and lessons learnt
(PLoS, 2016)Bioinformatics is now a critical skill in many research and commercial environments as biological data are increasing in both size and complexity. South African researchers recognized this need in the mid-1990s and responded ... -
A dimer of the toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins
(Public Library of Science, 2007-08-29)The Toll-like receptor 4 (TLR4) is a class I transmembrane receptor expressed on the surface of immune system cells. TLR4 is activated by exposure to lipopolysaccharides derived from the outer membrane of Gram negative ... -
Discovery of Compound A : a selective activator of the glucocorticoid receptor with anti-inflammatory and anti-cancer activity
(Impact Journals, 2015)Glucocorticoids are among the most effective anti-inflammatory drugs, and are widely used for cancer therapy. Unfortunately, chronic treatment with glucocorticoids results in multiple side effects. Thus, there was an ... -
Disease- and treatment-associated acquired glucocorticoid resistance
(BioScientifica, 2018-10-11)ENGLISH ABSTRACT: The development of resistance to glucocorticoids (GCs) in therapeutic regimens poses a major threat. Generally, GC resistance is congenital or acquired over time as a result of disease progression, prolonged ... -
Divide and conquer may not be the optimal approach to retain the desirable estrogenic attributes of the cyclopia nutraceutical extract, SM6Met
(Public Library of Science, 2015)The genus Cyclopia, an indigenous South African fynbos plant used to prepare honeybush tea, contains phytoestrogenic compounds. An extract from C. subternata, SM6Met, displays three desirable estrogenic attributes for ... -
DNA vaccines against mycoplasma elicit humoral immune responses in ostriches
(Frontiers Media, 2019-05-14)In ostriches, the population densities resulting from intensive rearing increases susceptibility to pathogens such as mycoplasmas. In addition to good management practices, vaccination offers an attractive alternative ... -
Evaluation of production and reproduction of three South African Angora goat CYP17 genotypes
(South African Society for Animal Science, 2017-06-05)Two CYP17 genes, located on different loci and expressing enzymes with significantly different activities, have been identified in the South African Angora goat population. Three unique genotypes (named He, Hu, and Ho), ... -
Evaluation of the phytoestrogenic activity of Cyclopia genistoides (honeybush) methanol extracts and relevant polyphenols
(American Chemical Society, 2007-04)Unfermented C. genistoides methanol extracts of different harvestings and selected polyphenols were evaluated for phytoestrogenic activity by comparing binding to both ER subtypes, transactivation of an ERE-containing ... -
The evolution of standards and data management practices in systems biology
(EMBO, 2015-12)Systems biology involves the integration of multiple heterogeneous data sets, in order to model and predict biological processes. The domain's interdisciplinary nature requires data, models and other research assets to be ... -
Exploration of the hypothalamic-pituitary-adrenal axis to improve animal welfare by mean of genetic selection : lessons from the South African merino
(MDPI, 2013)It is a difficult task to improve animal production by means of genetic selection, if the environment does not allow full expression of the animal’s genetic potential. This concept may well be the future for animal welfare, ... -
Extinction risk and diversification are linked in a plant biodiversity hotspot
(Public Library of Science, 2011-05)It is widely recognized that we are entering an extinction event on a scale approaching the mass extinctions seen in the fossil record. Present-day rates of extinction are estimated to be several orders of magnitude greater ...
