• Familial Waldenstrom's macroglobulinaemia: a case report 

      Getaz, E. P.; Staples, W. G. (HMPG, 1977-06)
      A patient with Waldenstrom's macroglobulinemia, whose father died of the same condition, is presented. The literature on familial occurrence of paraproteinaemia is briefly reviewed.
    • Guideline for the treatment of myelodysplastic syndromes (MDS) in South Africa 

      Louw, V. J.; Bassa, F.; Chan, S. W.; Dreosti, L.; Du Toit, M.; Ferreira, M.; Gartrell, K.; Gunther, K.; Jogessar, V.; Littleton, N.; Mahlangu, J.; McDonald, A.; Patel, M.; Pool, R.; Ruff, P.; Schmidt, A.; Sissolak, G.; Swart, A.; Verburgh, E.; Webb, M. J. (Health and Medical Publishing Group (HMPG), 2011-12)
      Introduction. Myelodysplastic syndromes (MDS) encompass a heterogeneous group of clonal haematopoietic disorders characterised by chronic and progressive cytopenias resulting from ineffective haematopoiesis. Treatment ...
    • Haemochromatosis : phenotype to genotype or man to molecules 

      Jacobs, P.; Wood, L. (Health and Medical Publishing Group (HMPG), 2013-06)
      This is the third in our vignettes that are centred on everyday clinical presentations. Each emphasises practical aspects of team-based care that are applicable to general practitioners, specialists and paramedical ...
    • Haemophilia 

      Getaz , E. P.; Staples, W. G.; Lurie, A. (HMPG, 1977-10)
      The clinical and haematological features of haemophilia are reviewed and the historical aspects, pathogenesis and genetics are discussed. The problems associated with management, such as factor replacement, home ...
    • Hemangiosarkoom van die bors : 'n gevallestudie en oorsig van die literatuur 

      Van Zyl, J. A.; Van der Walt, J. J.; Van Zyl, J. J. W. (Health and Medical Publishing Group (HMPG), 1975)
      In this case of angiosarcoma of the breast in a 55 yr old woman, the time from treatment to death was 41 mth, compared with 25 mth in collected cases from the literature. The possible value of adjuvant chemotherapy is ...
    • The HIV/AIDS epidemic in South Africa : convergence with tuberculosis, socioecological vulnerability, and climate change patterns 

      Abayomi, A.; Cowan, M. N. (Health & Medical Publishing Group, 2014-08)
      Recent assessment reports suggest that climate change patterns are threatening social and ecological vulnerability and resilience, with the strong potential of negatively affecting human health. Persons living with HIV/AIDS ...
    • HIV/AIDS-related non-Hodgkin’s lymphomas and confounders : preliminary report of the Sub-Saharan Africa Lymphoma Consortium (SSALC) 

      Ayers, Leona W.; Abayomi, E. Akin; Adebamowo, Clement; Chumba, David K.; Iliyasu, Yawale; Naresh, Kikkeri N.; NDung’u, Joseph R; Perner, Yvonne; Stevens, Wendy; Tumwine, Lynnette K. (BioMed Central, 2012-04)
      SSALC was established to characterize HIV/AIDS-related lymphoma and the indigenous background of malignant lymphomas (ML) in sub-Saharan Africa. Because WHO classified lymphoma subgroups can vary in prevalence African, ...
    • Idiopathic thrombocytopenic purpura and hyperthyroidism : A case report 

      Getaz, E. P.; Staples, W. G. (HMPG, 1977-08)
      A case of immune thrombocytopenic purpura (ITP) and hyperthyroidism is presented. The treatment of refractory ITP with immunosuppressive agents is briefly considered. In 1931 a patient with coexistent purpura and ...
    • Immune activation is associated with decreased thymic function in asymptomatic, untreated HIV infected individuals 

      Manjati, Thandiwe; Nkambule, Bongani; Ipp, Hayley (AOSIS Publishing, 2016-07-28)
      Background: Reduced thymic function causes poor immunological reconstitution in human immunodeficiency virus (HIV)-positive patients on combined antiretroviral therapy (cART). The association between immune activation ...
    • Laboratoriumstandaardisasie en kwaliteitskontrole in antistolterapie 

      Brink S.; Cloete H.; Roberts R.; Holm W. (HMPG, 1976-02)
      [No abstract available]
    • Lympho epithelioid cellular lymphoma (Lennert's lymphoma). A case report 

      Staples, W. G.; Getaz, E. P. (HMPG, 1977-04)
      A woman of 69 with Lennert's lymphoma (malignant lymphoma with a high content of epithelioid histiocytes) is described. The case is unique in that hepatosplenomegaly was the presenting feature (for which splenectomy was ...
    • Lymphomas of large cells 

      Staples, W. G.; Getaz, E. P. (Health & Medical Publishing Group, 1977)
      Historical aspects of the classification of large-cell lymphomas are described. Immunological characterization of the lymphomas is possible by identification of T and B lymphocytes according to their cell membrane surface ...
    • Mielopoiese : 'n kinetiese benadering 

      Brink, S.; Steytler, J. G. (Health and Medical Publishing Group (HMPG), 1975)
      The mechanisms of hemopoietic cellular proliferation are more clearly understood when the granulocytic, monocytic and macrophagic elements of the bone marrow are studied by means of in vitro cultures. Better physiological ...
    • Modulation of LPS-induced CD4+ T-cell activation and apoptosis by antioxidants in untreated asymptomatic HIV infected participants : an in vitro study 

      Wanjiku, Samuel Mburu; Marnewick, J. L.; Abayomi, A.; Ipp, H. (Hindawi Publishing Corporation, 2013-11)
      Persistent immune activation characterises HIV infection and is associated with depletion of CD4+ T-cells and increased risk of disease progression. Early loss of gutmucosal integrity results in the translocation of microbial ...
    • Myelodysplastic syndromes -- Diagnosis 

      Jacobs, Peter; Wood, Lucille (Health and Medical Publishing Group (HMPG), 2012-12)
      This is the second in our series of clinical articles that discuss everyday presentations. Each emphasises practical aspects of team-based care that are relevant for general practitioners, specialists and paramedical ...
    • Oorerflike faktor V gebrek (Parahemofilie) : 'n gevalbespreking 

      Brink S. (HMPG, 1974)
      A white boy and his family were investigated for a haemorrhagic diathesis. Both he and his sister, a primipara between 26 and 28 wk pregnant, in May 1973 had a total lack of factor V, demonstrated an abnormal partial ...
    • A perpetual source of DNA or something really different : ethical issues in the creation of cell lines for African genomics research 

      De Vries, Jantina; Abayomi, Akin; Brandful, James; Littler, Katherine; Madden, Ebony; Marshall, Patricia; Ouwe Missi Oukem-Boyer, Odile; Seeley, Janet (BioMed Central, 2014-08)
      Background: The rise of genomic studies in Africa - not least due to projects funded under H3Africa - is associated with the development of a small number of biorepositories across Africa. For the ultimate success of these ...
    • The present status of cytochemistry in the diagnosis of haematological malignancy 

      Staples, W. G.; Getaz, E. P. (HMPG, 1977-06)
      Newer concepts in the application of cytochemistry to the diagnosis of haematological malignancies are discussed. The underlying physiological principles and location of the various enzymes are indicated. Older stains, ...
    • Recommendations for the management of sickle cell disease in South Africa 

      Alli, N. A.; Patel, M.; Alli, H. D.; Bassa, F.; Coetzee, M. J.; Davidson, A.; Essop, M. R.; Lakha, A.; Louw, V. J.; Novitzky, N.; Philip, V.; Poole, J. E.; Wainwright, R. (Health & Medical Publishing Group, 2014-11)
      The spectrum of sickle cell disease (SCD) encompasses a heterogeneous group of disorders that include: (i) homozygous SCD (HbSS), also referred to as sickle cell anaemia; (ii) heterozygous SCD (HbAS), also referred to as ...
    • Serum ferritin and mean corpuscular volume as predictors of bone marrow iron stores 

      Brink S.; Van Schalkwyk D.J. (HMPG, 1982)
      The prognostic value of serum ferritin (SF) as a predictor of bone marrow iron stores (BMS) was evaluated in an attempt to use SF and other readily available clinical and laboratory parameters in the more accurate prediction ...