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The interaction between human spermatozoa and its homologous zona pellucida : scientific advances and clinical significance

dc.contributor.advisorFranken, D. R.
dc.contributor.authorOehninger, Sergio C.
dc.contributor.otherStellenbosch University. Faculty of Medicine & Health Sciences . Dept. of Obstetrics & Gynaecology.en_ZA
dc.date.accessioned2012-08-27T11:35:18Z
dc.date.available2012-08-27T11:35:18Z
dc.date.issued2002-12
dc.identifier.urihttp://hdl.handle.net/10019.1/53132
dc.descriptionThesis (PhD)--Stellenbosch University, 2002.en_ZA
dc.description.abstractENGLISH ABSTRACT: Infertility is a very common problem worldwide. Recent data have shown that disorders of the male represent the most common single defined cause of infertility. This proposal examines the clinical significance and fundamental physiological aspects of human gamete interaction. These studies are focused on the assessment of the cellular-molecular mechanisms involved in human sperm binding to its homologous zona pellucida resulting in the physiologic induction of the acrosome reaction. We have developed and validated in vitro bioassays that assess specific steps of the fertilization process that are critical for early embryo development. The results of our translational research have already had a significant impact on the overall evaluation of male infertility and on the clinical management of the infertile man in the assisted reproduction arena. Furthermore, the unveiling of the basic mechanisms involved in human gamete interaction will ultimately allow for both (i) the development of new male reproductive diagnostic capabilities and (ii) the design of improved and safer therapies aiding conception in childless couples suffering from male infertility.en_ZA
dc.description.abstractAFRIKAANSE OPSOMMING: Menslike onvrugbaarheid is 'n algemene wêreldwye probleem en onlangse data toon aan dat die manlike factor die grootste enkel bydraende factor tot hierdie toestand is. Die werk loods 'n intensiewe ondersoek na die kliniese betekenis en basiese fisiologiese aspekte wat 'n rol tydens spermsel en eisel interaksie speel. Hoofstuk 3 fokus op die sellulêre en molekulêre meganismes wat betrokke is tydens spermsel en eisel binding wat gevolglik lei tot akrosoomreaksie van die spermsel. Die werk verteenwoordig die resultate van 10 jaar se navorsing tussen die kandidaat en die promoter. Dit gee oorsprong aan 'n reeks bio-toetse wat die bevrugtingsproses koriografiese ontleed en verskaf dus 'n stap-vir-stap uiteenseting van menslike bevrugting en gevolglike embrio ontwikkeling. Die resultate in Hoostuk 4 bring vernuwing in die begrippe van die manlike faktor en die rol in die kinderlose huwelik. Die resulate soos in Hoofstuk 3 en 4 uiteengesit, vorm nie net die basis vir die moontlike ontwikkeling van nuwe diagnostiese benaderings tot die hantering van die man nies maar speel oojk 'n rol die daarstelling van verbeterde terapeutiese hantering van die kinderlose egpaar. Hoofstuk 5 gee kortliks riglyne en aanbevelings tot opsigte van die gebruik van die spermsel-zona pellucida bindingstoets en akrosomreaksie. Die kandidaat bevel aan dat die genoemde twee bio-toetse deel van die laboratorium ondersoeke van die man gebruik moet word.af_ZA
dc.format.extent247 p. : ill.
dc.language.isoen_ZAen_ZA
dc.publisherStellenbosch : Stellenbosch Universityen_ZA
dc.subjectInfertility, Maleen_ZA
dc.subjectHuman reproductive technologyen_ZA
dc.subjectZona pellucidaen_ZA
dc.subjectSpermatozoaen_ZA
dc.subjectDissertations -- Obstetrics and gynaecologyen_ZA
dc.subjectTheses -- Obstetrics and gynaecologyen_ZA
dc.subjectTheses -- Medicineen_ZA
dc.subjectDissertations -- Medicineen_ZA
dc.titleThe interaction between human spermatozoa and its homologous zona pellucida : scientific advances and clinical significanceen_ZA
dc.typeThesisen_ZA
dc.rights.holderStellenbosch Universityen_ZA


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