Recent Submissions

  • Fully automatic treatment planning for external-beam radiation therapy of locally advanced cervical cancer : a tool for low-resource clinics 

    Kisling, Kelly; Zhang, Lifei; Simonds, Hannah M.; Fakie, Nazia; Yang, Jinzhong; McCarroll, Rachel; Balter, Peter; Burger, Hester; Bogler, Oliver; Howell, Rebecca; Schmeler, Kathleen; Mejia, Mike; Beadle, Beth M.; Jhingran, Anuja; Court, Laurence (American Society of Clinical Oncology, 2019)
    PURPOSE: The purpose of this study was to validate a fully automatic treatment planning system for conventional radiotherapy of cervical cancer. This system was developed to mitigate staff shortages in low-resource ...
  • A risk assessment of automated treatment planning and recommendations for clinical deployment 

    Kisling, Kelly; Johnson, Jennifer L.; Simonds, Hannah M.; Zhang, Lifei; Jhingran, Anuja; Beadle, Beth M.; Burger, Hester; Du Toit, Monique; Joubert, Nanette; Makufa, Remigio; Shaw, William; Trauernicht, Christoph; Balter, Peter; Howell, Rebecca M.; Schmeler, Kathleen; Court, Laurence (American Association of Physicists in Medicine, 2019-06)
    Purpose: To assess the risk of failure of a recently developed automated treatment planning tool, the radiation planning assistant (RPA), and to determine the reduction in these risks with implementation of a quality ...
  • Automated treatment planning of postmastectomy radiotherapy 

    Kisling, Kelly; Zhang, Lifei; Shaitelman, Simona F.; Anderson, David; Thebe, Tselane; Yang, Jinzhong; Balter, Peter A.; Howell, Rebecca M.; Jhingran, Anuja; Schmeler, Kathleen; Simonds, Hannah; Du Toit, Monique; Trauernicht, Christoph; Burger, Hester; Botha, Kobus; Joubert, Nanette; Beadle, Beth M.; Court, Laurence (American Association of Physicists in Medicine, 2019-05-11)
    Purpose: Breast cancer is the most common cancer in women globally and radiation therapy is a cornerstone of its treatment. However, there is an enormous shortage of radiotherapy staff, especially in low- and middle-income ...
  • The utility of PET-CT in the staging and management of advanced and recurrent malignant melanoma 

    Twycross, S. H.; Burger, Henriette; Holness, Jen L. (Medpharm Publications, 2019)
    BACKGROUND: Accurate pre-operative staging and correct surgical selection of patients with malignant melanoma reduces unnecessary morbidity and mortality, improves distant control and may improve survival. 18F-fluorodeoxyglucose ...
  • Managing gestational trophoblastic neoplasm (GTN) and people living with HIV (PLWH) 

    Barnardt, Pieter (MedPharm Publications, 2019)
    The 2017 World Health Organization (WHO) global report on HIV/AIDS estimated that sub-Saharan Africa comprised 64% of the global HIV burden, with a current estimate of 19.4 million cases in Eastern and Southern Africa. ...
  • Malignant peripheral nerve sheath tumours and neurofibromatosis 1 : a case series and recommendations for care 

    Burger, Henriette; Bezuidenhout, Heidre; Sher-Locketz, Candice; Baatjes, Karin; Van Wyk, Jacques; Bonthuys, Anita (AOSIS, 2018-08-20)
    Background: The incidence of malignant peripheral nerve sheath tumours (MPNST) in patients with neurofibromatosis 1 (NF1) is significantly higher than that of the general population. NF1-associated MPNST occur at a younger ...
  • Chemotherapy administration standards and guidelines : the development of a resource document 

    Eedes, David J.; Bailey, Belinda; Burger, Henriette (AOSIS, 2018-08-13)
    There are no nationally recognised guidelines for the handling and administration of chemotherapy in South Africa. The Independent Clinical Oncology Network’s Chemotherapy Administration Standards and Guidelines Resource ...
  • Hypofractionation and prostate cancer : a good option for Africa? 

    Incrocci, Luca; Heijmen, Ben; Kupelian, Patrick; Simonds, Hannah M. (AOSIS, 2017-08-29)
    Cancer is an emerging public health problem in Africa. According to the World Health Organization, the numbers will be doubled by 2030 because of the ageing and the growth of the population. Prostate cancer is the most ...
  • Results from extended lymphadenectomies with [111In]PSMA-617 for intraoperative detection of PSMA-PET/CT-positive nodal metastatic prostate cancer 

    Jilg, Cordula A.; Reichel, Kathrin; Stoykow, Christian; Rischke, H. C.; Bartholoma, Mark; Drendel, Vanessa; Von Buren, Moritz; Schultze-Seemann, Wolfgang; Meyer, Philipp T,; Mix, Michael (SpringerOpen (part of Springer Nature), 2020-03-06)
    Purpose: Identification of suspicious PSMA-PET/CT-positive lymph node (LN) metastases (LNM) from prostate cancer (PCa) during lymphadenectomy (LA) is challenging. We evaluated an 111In-labelled PSMA ligand (DKFZ-617, referred ...
  • Radiation planning assistant - a streamlined, fully automated radiotherapy treatment planning system 

    Court, Laurence E.; Kisling, Kelly; McCarroll, Rachel; Zhang, Lifei; Yang, Jinzhong; Simonds, Hannah; Du Toit, Monique; Trauernicht, Chris; Burger, Hester; Parkes, Jeannette; Mejia, Mike; Bojador, Maureen; Balter, Peter; Branco, Daniela; Steinmann, Angela; Baltz, Garrett; Gay, Skylar; Anderson, Brian; Cardenas, Carlos; Jhingran, Anuja; Shaitelman, Simona; Bogler, Oliver; Schmeller, Kathleen; Followill, David; Howell, Rebecca; Nelson, Christopher; Peterson, Christine; Beadle, Beth (Journal of Visualized Experiments, 2018)
    The Radiation Planning Assistant (RPA) is a system developed for the fully automated creation of radiotherapy treatment plans, including volume-modulated arc therapy (VMAT) plans for patients with head/neck cancer and ...
  • Retrospective analysis of radiotherapy outcomes in breast cancer radiotherapy at a single institution 

    Heunis, M.; Lombe, D. C.; McCaulb, M. (Medpharm Publications, 2018)
    Introduction: Breast cancer is the most commonly diagnosed cancer worldwide. With the challenges of cancer treatment in developing countries there is a need for a systematic and methodical approach to treatment in ...
  • A retrospective analysis of the effect of planning tumour volume on survival in cervical carcinoma 

    Fourie, Ilze; Simonds, Hannah M. (Medpharm Publications, 2018)
    Introduction: Locally advanced stages of invasive cervical cancer (ICC) are associated with poor outcomes; factors influencing survival include increased tumour volume. In resource-constrained settings access to diagnostic ...
  • Ovarian germ cell tumour and bleomycin-induced lung injury 

    Barnardt, Pieter; Griffith-Richards, Stephanie (Medpharm Publications, 2018)
    Bleomycin, an antibiotic agent with antitumour activity, is an important drug in the management of many oncological malignancies such as lymphoma and germ cell tumours. These tumours are potentially curable and mostly ...
  • Medical students' perceptions on euthanasia and physician-assisted suicide : are they fully informed? 

    Burger, H.; Gwyther, L.; Krause, R.; Ratshikana-Moloko, M.; Hellenberg, D. (Health & Medical Publishing Group, 2018)
    No abstract available
  • Establishing a multidisciplinary AIDS-associated Kaposi’s sarcoma clinic : patient characteristics, management and outcomes 

    Burger, H.; Ismail, Z.; Taljaard, J. J. (Health & Medical Publishing Group, 2018-12)
    Background: Kaposi’s sarcoma (KS) typically occurs in the setting of immunodeficiency and specifically in the presence of HIV infection, when it is called AIDS-associated KS (AIDS-KS). In spite of impressive gains in the ...
  • Audits of oncology units – an effective and pragmatic approach 

    Abratt, R. P.; Eedes, D.; Bailey, B.; Salmon, C.; Govender, Y.; Oelofse, I.; Burger, H. (Health and Medical Publishing Group, 2017)
    Background. Audits of oncology units are part of all quality-assurance programmes. However, they do not always come across as pragmatic and helpful to staff. Objective. To report on the results of an online survey on ...
  • Gestational trophoblastic neoplasm and women living with HIV and/or AIDS 

    Barnardt, Pieter; Relling, Martha (AOSIS Publishing, 2015-07-03)
    The 2011 World Health Organization global report on HIV and/or AIDS estimated that sub-Saharan Africa comprised 67% of the global HIV burden, with a current estimate of 5.9 million cases in South Africa. Since the introduction ...
  • Primary breast lymphoma and HIV/AIDS 

    Barnardt, Pieter; Narinesingh, Dylan (AOSIS OpenJournals, 2011-09)
    Primary extranodal lymphoma of the breast is rare and accounts for 0.04 - 0.53% of all malignant tumours, less than 1% of non-Hodgkin’s lymphomas (NHLs) and 1.7% of extranodal NHLs.1 Extranodal lymphoma arises from tissue ...
  • Managing AIDS-related Kaposi’s sarcoma and pregnancy 

    Barnardt, Pieter (AOSIS Publishing, 2013-05)
    An estimated 30 - 40% of HIV-infected patients are likely to develop cancer during the progression of their disease. The occurrence of malignancy among these patients represents a difficult challenge in their care. Kaposi’s ...
  • Plasma sarcosine does not distinguish early and advanced stages of prostate cancer 

    Bohm, L.; Serafin, A. M.; Fernandez, P.; Van der Watt, G.; Bouic, P. J. D.; Harvey, J. (Health and Medical Publishing Group (HMPG), 2012-08)
    Introduction. Diagnosis of prostate cancer by prostate specific antigen (PSA) is error-prone and cannot distinguish benign prostatic hyperplasia (BPH) from malignant disease, nor identify aggressive and indolent types. ...

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