• SDS interferes with SaeS signalling of Staphylococcus aureus independently of SaePQ 

      Makgotlho, Phuti E.; Marincola, Gabriella; Schafer, Daniel; Liu, Qian; Bae, Taeok; Geiger, Tobias; Wasserman, Elizabeth; Wolz, Christiane; Ziebuhr, Wilma; Sinha, Bhanu (Public Library of Science, 2013-08-20)
      The Staphylococcus aureus regulatory saePQRS system controls the expression of numerous virulence factors, including extracellular adherence protein (Eap), which amongst others facilitates invasion of host cells. The saePQRS ...
    • Stool culture for diagnosis of pulmonary tuberculosis in children 

      Walters, Elisabetta; Demers, Anne-Marie; Van der Zalm, Marieke M.; Whitelaw, Andrew; Palmer, Megan; Bosch, Corne; Draper, Heather R.; Gie, Robert P.; Hesseling, Anneke C. (American Society for Microbiology, 2017-12)
      Bacteriological confirmation of Mycobacterium tuberculosis is achieved in the minority of young children with tuberculosis (TB), since specimen collection is resource intensive and respiratory secretions are mostly ...
    • Surveillance of healthcare-associated infection in hospitalised South African children : Which method performs best? 

      Dramowski, Angela; Cotton, M. F.; Whitelaw, A. (Health & Medical Publishing Group, 2017)
      Background. In 2012, the South African (SA) National Department of Health mandated surveillance of healthcare-associated infection (HAI), but made no recommendations of appropriate surveillance methods. Methods. Prospective ...
    • Susceptibility of a series of routine sputum samples for antituberculosis chemotherapy in Gweru, Zimbabwe 

      Apers, L. M.; Chihota, V. (Health & Medical Publishing Group, 2004)
      Resistance of Mycobacterium tuberculosis to the commonly used antibiotics in national tuberculosis programmes (NTPs) is a growing concern in many parts of the world.1 Nevertheless there is much anecdotal, but ...
    • Time for a culture change? suboptimal compliance with blood culture standards at a district hospital in Cape Town 

      Abrahams, Mohammad Shareef; Whitelaw, Andrew C.; Orth, Heidi (Health and Medical Publishing Group, 2015)
      Background. The benchmark for contaminated blood cultures (BCs) is 3%. The South African (SA) guideline aims to optimise BC yield and reduce contamination. Data on BC collection practices in SA since the publication of the ...
    • Tuberculosis research : the way forward 

      Beyers, A. D.; Donald, P. R.; Van Helden, P. D.; Ehlers, M. R. W.; Steyn, L.; Mizrahi, V. (Health & Medical Publishing Group, 1996)
      Tuberculosis is back on the world stage with a vengeance, perhaps at least partly as a consequence of complacency about the threat it posed in the recent past.
    • Whole-genome sequence of a mycobacterium goodii isolate from a pediatric patient in South Africa 

      Allam, Mushal; Joseph, Lavania; Ismail, Farzana; Said, Halima; Ismail, Nazir A.; Ismail, Arshad; Mtshali, Senzo; Mnyameni, Florah; Goussard, Pierre; Pekeur, Jade C.; Lourens, Adre; Omar, Shaheed V. (American Society for Microbiology, 2018)
      ENGLISH ABSTRACT: We describe here the draft genome sequence of a Mycobacterium goodii isolate from a pediatric patient in Western Cape, South Africa. To our knowledge, this is the second reported genome of this rapidly ...
    • Xenorhabdus khoisanae SB10 produces Lys-rich PAX lipopeptides and a Xenocoumacin in its antimicrobial complex 

      Dreyer, J.; Rautenbach, Marina; Booysen, E.; van Staden, A. D.; Deane, S. M.; Dicks, L. M. T. (BMC (part of Springer Nature), 2019-06-13)
      Background: Xenorhabdus spp. live in close symbiosis with nematodes of the Steinernema genus. Steinernema nematodes infect an insect larva and release their symbionts into the haemocoel of the insect. Once released into the ...