• Toxicity associated with tuberculosis chemotherapy in the REMoxTB study 

      Tweed, Conor D.; Crook, Angela M.; Amukoye, Evans I.; Dawson, Rodney; Diacon, Andreas H.; Hanekom, Madeline; McHugh, Timothy D.; Mendel, Carl M.; Meredith, Sarah K.; Murphy, Michael E.; Murthy, Saraswathi E.; Nunn, Andrew J.; Phillips, Patrick P. J.; Singh, Kasha P.; Spigelman, Melvin; Wills, Genevieve H.; Gillespie, Stephen H. (BioMed Central, 2018-07-11)
      Background: The incidence and severity of tuberculosis chemotherapy toxicity is poorly characterised. We used data available from patients in the REMoxTB trial to provide an assessment of the risks associated with the ...
    • Treatment with a fixed dose combination antiretroviral therapy drug containing tenofovir, emtricitabine and efavirenz is associated with cardioprotection in high calorie diet-induced obese rats 

      Everson, Frans; Genis, Amanda; Ogundipe, Temitope; De Boever, Patrick; Goswami, Nandu; Lochner, Amanda; Blackhurst, Dee; Strijdom, Hans (Public Library of Science, 2018-12-05)
      HIV-infection, certain antiretroviral drug classes, especially protease inhibitors (PI), and obesity are associated with increased ischaemic heart disease (IHD) risk. However, the effect of PI-free fixed dose combination ...
    • Utility of antioxidants during assisted reproductive techniques : an evidence based review 

      Agarwal, Ashok; Durairajanayagam, Damayanthi; Du Plessis, Stefan S. (BioMed Central, 2014-11-24)
      Assisted reproductive technology (ART) is a common treatment of choice for many couples facing infertility issues, be it due to male or female factor, or idiopathic. Employment of ART techniques, however, come with its ...
    • Weight loss in obese women - exercise v. dietary education 

      Bertram, S. R.; Venter, I.; Stewart, R. I. (Health & Medical Publishing Group, 1990)
      It was postulated that a nutrition-education programme was as effective an adjunct to a diet-based weight-loss programme as an exercise regimen. Forty-five obese female volunteers were placed on the same 5000 kJ diet and ...
    • Xpert MTB/RIF assay shows faster clearance of Mycobacterium tuberculosis DNA with higher levels of rifapentine exposure 

      Jayakumar, A.; Savic, R. M.; Everett, C. K.; Benator, D.; Alland, D.; Heilig, C. M.; Weiner, M.; Friedrich, S. O.; Martinson, N. A.; Kerrigan, A.; Zamudio, C.; Goldberg, S. V.; Whitworth, W. C.; Davis, J. L.; Nahid, P. (American Society for Microbiology, 2016-12)
      The Xpert MTB/RIF assay is both sensitive and specific as a diagnostic test. Xpert also reports quantitative output in cycle threshold (CT ) values, which may provide a dynamic measure of sputum bacillary burden when used ...