• Die kliniese belang van fosfolipiede longpatologie 

      Van Papendorp, D. H.; Engelbrecht, F. M. (Health & Medical Publishing Group, 1981)
      The phospholipid composition of 35 human lungs with pathological lesions was analysed by means of thin-layer chromatography and densitometric scanning. The pathological conditions studied were: bronchopneumonia, myocardial ...
    • Melatonin prevents cardioprotection induced by a multi-cycle ischaemic preconditioning protocol in the isolated perfused rat heart 

      Genade, S.; Ytrehus, K.; Lochner, A. (Clinics Cardiv Publishing, 2006-10)
      The powerful cardioprotective actions of melatonin, the chief secretory product of the pineal gland, have been attributed largely to its free radical-scavenging properties. Free radicals play an important role in the ...
    • Metabolic changes in the lungs after ischaemia 

      Engelbrecht, F. M.; Edwards, I. J.; De Beer, D. P. (Health & Medical Publishing Group, 1980)
      The effects of variable periods of ischaemia on the isolated lungs of rats and rabbits, stored for up to 6 hours at 4°C, 21°C and 37°C under standardized conditions, were investigated in vitro in terms of oxygen consumption, ...
    • Minimum Information About a Simulation Experiment (MIASE) 

      Waltemath, Dagmar; Adams, Richard (Public Library of Science (PLOS), 2011-04)
      Reproducibility of experiments is a basic requirement for science. Minimum Information (MI) guidelines have proved a helpful means of enabling reuse of existing work in modern biology. The Minimum Information Required in ...
    • Mycobactericidal activity of sutezolid (PNU-100480) in sputum (EBA) and blood (WBA) of patients with pulmonary tuberculosis 

      Wallis, Robert S.; Dawson, Rodney; Friedrich, Sven O.; Venter, Amour; Paige, Darcy; Zhu, Tong; Silvia, Annette; Gobey, Jason; Ellery, Craig; Zhang, Yao; Eisenach, Kathleen; Miller, Paul; Diacon, Andreas H. (PLoS, 2014-04-14)
      Rationale: Sutezolid (PNU-100480) is a linezolid analog with superior bactericidal activity against Mycobacterium tuberculosis in the hollow fiber, whole blood and mouse models. Like linezolid, it is unaffected by mutations ...
    • Myocardial susceptibility to ischaemia/reperfusion in obesity : a re-evaluation of the effects of age 

      Webster, I.; Salie, R.; Marais, E.; Fan, W. J.; Maarman, G.; Huisamen, B.; Lochner, A. (BioMed Central, 2017-03-17)
      Background Reports on the effect of age and obesity on myocardial ischaemia/reperfusion (I/R) injury and ischaemic preconditioning are contradictory. The aim of this study was to re-evaluate the effects of age and ...
    • New emphasis on atrial cardiology 

      Mouton, R.; Lochner, De J. V.; Lochner, A. (Health & Medical Publishing Group, 1992)
      Based on the concept that the cardiac muscle is differentiated mainly for excitation, conduction and contraction, cardiology has for many years focused mainly on the ventricles, with comparatively little attention to ...
    • A new trial design to accelerate tuberculosis drug development : the Phase IIC Selection Trial with Extended Post-treatment follow-up (STEP) 

      Phillips, Patrick P. J.; Dooley, Kelly E.; Gillespie, Stephen H.; Heinrich, Norbert; Stout, Jason E.; Nahid, Payam; Diacon, Andreas H.; Aarnoutse, Rob E.; Kibiki, Gibson S.; Boeree, Martin J.; Hoelscher, Michael (BioMed Central, 2016-03-23)
      Background: The standard 6-month four-drug regimen for the treatment of drug-sensitive tuberculosis has remained unchanged for decades and is inadequate to control the epidemic. Shorter, simpler regimens are urgently ...
    • Nutritional support in sepsis : when less may be more 

      Van Niekerk, Gustav; Meaker, Charne; Engelbrecht, Anna-Mart (BMC (part of Springer Nature), 2020-02-14)
      Despite sound basis to suspect that aggressive and early administration of nutritional support may hold therapeutic benefits during sepsis, recommendations for nutritional support have been somewhat underwhelming. ...
    • Phase 2b controlled trial of M72/AS01E vaccine to prevent tuberculosis 

      Van der Meeren, Olivier; Hatherill, Mark; Nduba, Videlis; Wilkinson, Robert J.; Muyoyeta, Monde; Van Brakel, Elana; Ayles, Helen M.; Henostroza, German; Thienemann, Friedrich; Scriba, Thomas J.; Diacon, Andreas; Blatner, Gretta L.; Demoitie, Marie-Ange; Tameris, Michele; Malahleha, Mookho; Innes, James C.; Hellstrom, Elizabeth; Martinson, Neil; Singh, Tina; Akite, Elaine J.; Khatoon Azam, Aisha; Bollaerts, Anne; Ginsberg, Ann M.; Evans, Thomas G.; Gillard, Paul; Tait, Dereck R. (Massachusetts Medical Society, 2018-10-25)
      BACKGROUND: A vaccine to interrupt the transmission of tuberculosis is needed. METHODS: We conducted a randomized, double-blind, placebo-controlled, phase 2b trial of the M72/AS01E tuberculosis vaccine in Kenya, South ...
    • Population pharmacokinetic/pharmacodynamic analysis of the bactericidal activities of sutezolid (PNU-100480) and its major metabolite against intracellular mycobacterium tuberculosis in ex vivo whole-blood cultures of patients with pulmonary tuberculosis 

      Zhu, Tong; Friedrich, Sven O.; Diacon, Andreas; Wallis, Robert S. (American Society for Microbiology, 2014)
      Sutezolid (PNU-100480 [U-480]) is an oxazolidinone antimicrobial being developed for the treatment of tuberculosis. An active sulfoxide metabolite (PNU-101603 [U-603]), which reaches concentrations in plasma several times ...
    • The prevalence of exercise-induced broncho-constriction in Cape Town schoolchildren 

      Terblanche, E.; Stewart, R. I. (Health & Medical Publishing Group, 1990)
      An attempt was made to determine: (i) the prevalence of exercise-induced bronchoconstriction among white and coloured schoolchildren in Cape Town; and (ii) the validity of an exercise test for the diagnosis of asthma in ...
    • The prevalence of type 2 diabetes in South Africa : a systematic review protocol 

      Pheiffer, Carmen; Pillay-Van Wyk, Victoria; Joubert, Jane D.; Levitt, Naomi; Nglazi, Mweete D.; Bradshaw, Debbie (BMJ Publishing Group, 2018-06)
      Introduction Type 2 diabetes mellitus is a major source of morbidity and mortality in South Africa, spurred by increased urbanisation and unhealthy lifestyle factors. Local epidemiological data are required to inform ...
    • Protection of the ischaemic heart : investigations into the phenomenon of ischaemic preconditioning 

      Lochner, A.; Marais, E.; Genade, S.; Huisamen, B.; Du Toit, E. F.; Moolman, J. A. (Clinics Cardiv Publishing, 2009-02)
      Exposure of the heart to one or more short episodes of ischaemia/reperfusion protects the heart against a subsequent prolonged period of ischaemia, as evidenced by a reduction in infarct size and an improvement in ...
    • Proteomic analysis of human spermatozoa proteins with oxidative stress 

      Sharma, Rakesh; Agarwal, Ashok; Mohanty, Gayatri; Hamada, Alaa J.; Gopalan, Banu; Willard, Belinda; Yadav, Satya; Du Plessis, Stefan (BioMed Central, 2013-05)
      Background: Oxidative stress plays a key role in the etiology of male infertility. Significant alterations in the sperm proteome are associated with poor semen quality. The aim of the present study was to examine if elevated ...
    • Proteomic analysis of seminal fluid from men exhibiting oxidative stress 

      Sharma, Rakesh; Agarwal, Ashok; Mohanty, Gayatri; Du Plessis, Stefan S.; Gopalan, Banu; Willard, Belinda; Yadav, Satya P.; Sabanegh, Edmund (BioMed Central, 2013-09)
      ABSTRACT: Background: Seminal plasma serves as a natural reservoir of antioxidants. It helps to remove excessive formation of reactive oxygen species (ROS) and consequently, reduce oxidative stress. Proteomic profiling of ...
    • Proteomics : a subcellular look at spermatozoa 

      Du Plessis, Stefan S.; Kashou, Anthony H.; Benjamin, David J.; Yadav, Satya P.; Agarwal, Ashok (BioMed Central, 2011-03)
      Abstract. Background. Male-factor infertility presents a vexing problem for many reproductively active couples. Many studies have focused on abnormal sperm parameters. Recent advances in proteomic techniques, especially ...
    • Rapid induction of ageing character in brandy products : ageing and general overview 

      Van Jaarsveld, F. P.; Hattingh, S. M. (South African Society for Enology and Viticulture, 2012)
      Ageing is one of the most important and most costly factors determining the quality of distilled beverages. As part of a broader study that investigated techniques for the rapid induction of a desirable ageing character in ...
    • Rapid induction of ageing character in brandy products. Part I. Effects of extraction media and preparation conditions 

      Van Jaarsveld, F. P.; Hattingh, S.; Minnaar, P.; Blom, M. (SASEV, 2009-10)
      The purpose of this study was to investigate the use of different wood types and treatments, and extraction media to induce rapid ageing of brandy. Extracts were prepared from American and French oak, specially prepared ...
    • Rapid induction of ageing character in brandy products. Part II, Influence of type of oak 

      Van Jaarsveld, F. P.; Hattingh, S.; Minnaar, P. (SASEV, 2009)
      As part of a broader study that investigated techniques for the rapid induction of the needed ageing character in brandy products, the effect of oak type on quality and chemical composition of oak wood extracts and matured ...