Browsing Research Articles (Medical Physiology) by Title
Now showing items 25-44 of 54
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High carbohydrate and high fat diets protect the heart against ischaemia/reperfusion injury
(BioMed Central Ltd., 2014-07-18)Background: Although obesity is still considered a risk factor in the development of cardiovascular disorders, recent studies suggested that it may also be associated with reduced morbidity and mortality, the so-called ... -
High fat programming and cardiovascular disease
(MDPI, 2018)ENGLISH ABSTRACT: Programming is triggered through events during critical developmental phases that alter offspring health outcomes. High fat programming is defined as the maintenance on a high fat diet during fetal and/or ... -
High resolution imaging study of interactions between the 37 kDa/67 kDa Laminin receptor and APP, beta-secretase and gamma-secretase in Alzheimer’s Disease
(PLoS, 2014-06-27)Alzheimer's disease (AD) is the most prevalent form of dementia affecting the elderly. Neurodegeneration is caused by the amyloid beta (Aβ) peptide which is generated from the sequential proteolytic cleavage of the Amyloid ... -
Influence of ejaculation frequency on seminal parameters
(BioMed Central, 2015-05-21)Background: Several factors have been shown to influence semen parameters, one of which is sexual abstinence; a clinical criteria included in the semen evaluation to provide maximum sperm quality. The aim of the present ... -
An investigation of excess residual cytoplasm in human spermatozoa and its distinction from the cytoplasmic droplet
(BioMed Cenral, 2012-11-17)Recent studies have shown cytoplasmic droplets to be normal morphological occurrences in human male spermatozoa. When the cytoplasm around the sperm midpiece is present in large amounts, however, pathological effects may ... -
Ischaemic postconditioning : from bench to bedside …
(Clinics Cardiv Publishing, 2008-12)The increase in the incidence of ischaemic heart disease and acute myocardial infarction (AMI) in both high- and lowincome countries necessitates the development of myocardial salvaging/protection interventions, to be ... -
Melatonin prevents cardioprotection induced by a multi-cycle ischaemic preconditioning protocol in the isolated perfused rat heart
(Clinics Cardiv Publishing, 2006-10)The powerful cardioprotective actions of melatonin, the chief secretory product of the pineal gland, have been attributed largely to its free radical-scavenging properties. Free radicals play an important role in the ... -
Minimum Information About a Simulation Experiment (MIASE)
(Public Library of Science (PLOS), 2011-04)Reproducibility of experiments is a basic requirement for science. Minimum Information (MI) guidelines have proved a helpful means of enabling reuse of existing work in modern biology. The Minimum Information Required in ... -
Mycobactericidal activity of sutezolid (PNU-100480) in sputum (EBA) and blood (WBA) of patients with pulmonary tuberculosis
(PLoS, 2014-04-14)Rationale: Sutezolid (PNU-100480) is a linezolid analog with superior bactericidal activity against Mycobacterium tuberculosis in the hollow fiber, whole blood and mouse models. Like linezolid, it is unaffected by mutations ... -
Myocardial susceptibility to ischaemia/reperfusion in obesity : a re-evaluation of the effects of age
(BioMed Central, 2017-03-17)Background Reports on the effect of age and obesity on myocardial ischaemia/reperfusion (I/R) injury and ischaemic preconditioning are contradictory. The aim of this study was to re-evaluate the effects of age and ... -
A new trial design to accelerate tuberculosis drug development : the Phase IIC Selection Trial with Extended Post-treatment follow-up (STEP)
(BioMed Central, 2016-03-23)Background: The standard 6-month four-drug regimen for the treatment of drug-sensitive tuberculosis has remained unchanged for decades and is inadequate to control the epidemic. Shorter, simpler regimens are urgently ... -
Phase 2b controlled trial of M72/AS01E vaccine to prevent tuberculosis
(Massachusetts Medical Society, 2018-10-25)BACKGROUND: A vaccine to interrupt the transmission of tuberculosis is needed. METHODS: We conducted a randomized, double-blind, placebo-controlled, phase 2b trial of the M72/AS01E tuberculosis vaccine in Kenya, South ... -
Population pharmacokinetic/pharmacodynamic analysis of the bactericidal activities of sutezolid (PNU-100480) and its major metabolite against intracellular mycobacterium tuberculosis in ex vivo whole-blood cultures of patients with pulmonary tuberculosis
(American Society for Microbiology, 2014)Sutezolid (PNU-100480 [U-480]) is an oxazolidinone antimicrobial being developed for the treatment of tuberculosis. An active sulfoxide metabolite (PNU-101603 [U-603]), which reaches concentrations in plasma several times ... -
The prevalence of type 2 diabetes in South Africa : a systematic review protocol
(BMJ Publishing Group, 2018-06)Introduction Type 2 diabetes mellitus is a major source of morbidity and mortality in South Africa, spurred by increased urbanisation and unhealthy lifestyle factors. Local epidemiological data are required to inform ... -
Protection of the ischaemic heart : investigations into the phenomenon of ischaemic preconditioning
(Clinics Cardiv Publishing, 2009-02)Exposure of the heart to one or more short episodes of ischaemia/reperfusion protects the heart against a subsequent prolonged period of ischaemia, as evidenced by a reduction in infarct size and an improvement in ... -
Proteomic analysis of human spermatozoa proteins with oxidative stress
(BioMed Central, 2013-05)Background: Oxidative stress plays a key role in the etiology of male infertility. Significant alterations in the sperm proteome are associated with poor semen quality. The aim of the present study was to examine if elevated ... -
Proteomic analysis of seminal fluid from men exhibiting oxidative stress
(BioMed Central, 2013-09)ABSTRACT: Background: Seminal plasma serves as a natural reservoir of antioxidants. It helps to remove excessive formation of reactive oxygen species (ROS) and consequently, reduce oxidative stress. Proteomic profiling of ... -
Proteomics : a subcellular look at spermatozoa
(BioMed Central, 2011-03)Abstract. Background. Male-factor infertility presents a vexing problem for many reproductively active couples. Many studies have focused on abnormal sperm parameters. Recent advances in proteomic techniques, especially ... -
Rapid induction of ageing character in brandy products : ageing and general overview
(South African Society for Enology and Viticulture, 2012)Ageing is one of the most important and most costly factors determining the quality of distilled beverages. As part of a broader study that investigated techniques for the rapid induction of a desirable ageing character in ... -
Rapid induction of ageing character in brandy products. Part I. Effects of extraction media and preparation conditions
(SASEV, 2009-10)The purpose of this study was to investigate the use of different wood types and treatments, and extraction media to induce rapid ageing of brandy. Extracts were prepared from American and French oak, specially prepared ...
