• Haemorrhagic shock : metabolic parameters for the assessment of damage in lung, liver and kidney tissue 

      Engelbrecht, F. M.; Mattheyse, F. J.; Mouton, W. L. (Health & Medical Publishing Group, 1984)
      Changes in catabolic and biosynthetic parameters measured in vitro were used as criteria to assess the degree of damage in tissues after an animal was exposed to severe haemorrhagic shock for periods of 1 and 2 hours (blood ...
    • High carbohydrate and high fat diets protect the heart against ischaemia/reperfusion injury 

      Salie, Ruduwaan; Huisamen, Barbara; Lochner, Amanda (BioMed Central Ltd., 2014-07-18)
      Background: Although obesity is still considered a risk factor in the development of cardiovascular disorders, recent studies suggested that it may also be associated with reduced morbidity and mortality, the so-called ...
    • High fat programming and cardiovascular disease 

      Cerf, Marlon E. (MDPI, 2018)
      ENGLISH ABSTRACT: Programming is triggered through events during critical developmental phases that alter offspring health outcomes. High fat programming is defined as the maintenance on a high fat diet during fetal and/or ...
    • High resolution imaging study of interactions between the 37 kDa/67 kDa Laminin receptor and APP, beta-secretase and gamma-secretase in Alzheimer’s Disease 

      Jovanovic, Katarina; Loos, Ben; Da Costa Dias, Bianca; Penny, Clement; Weiss, Stefan F. T. (PLoS, 2014-06-27)
      Alzheimer's disease (AD) is the most prevalent form of dementia affecting the elderly. Neurodegeneration is caused by the amyloid beta (Aβ) peptide which is generated from the sequential proteolytic cleavage of the Amyloid ...
    • Highly active antiretroviral therapy alters sperm parameters and testicular antioxidant status in diet-induced obese rats 

      Oyeyipo, Ibukun P.; Skosana, Bongekile T.; Everson, Frans P.; Strijdom, Hans; Du Plessis, Stefan S. (Korean Society of Toxicology, 2018)
      The efficacy of highly active antiretroviral therapy (HAART) has led to an increase demand for therapeutic use, thereby necessitating investigation into drug toxicity. This study was designed to investigate the in vivo ...
    • Human chorionic gonadotrophin and weight loss : a double-blind, placebo-controlled trial 

      Bosch, B.; Venter, I.; Stewart, R. I.; Bertram, S. R. (Health & Medical Publishing Group, 1990)
      Low-dose human chorionic gonadotrophin (HCG) combined with a severe diet remains a popular treatment for obesity, despite equivocal evidence of its effectiveness. In a double-blind, placebo-controlled study, the effects ...
    • Influence of ejaculation frequency on seminal parameters 

      Mayorga-Torres, B. Jose Manuel; Camargo, Mauricio; Agarwal, Ashok; Du Plessis, Stefan S.; Cadavid, Angela P.; Maya, Walter D. Cardona (BioMed Central, 2015-05-21)
      Background: Several factors have been shown to influence semen parameters, one of which is sexual abstinence; a clinical criteria included in the semen evaluation to provide maximum sperm quality. The aim of the present ...
    • An investigation of excess residual cytoplasm in human spermatozoa and its distinction from the cytoplasmic droplet 

      Rengan, A. K.; Agarwal, A.; Van der Linde, M.; Du Plessis, S. S. (BioMed Cenral, 2012-11-17)
      Recent studies have shown cytoplasmic droplets to be normal morphological occurrences in human male spermatozoa. When the cytoplasm around the sperm midpiece is present in large amounts, however, pathological effects may ...
    • Die invloed van oefening-geinduseerde brongokonstriksie op georganiseerde sportdeelname 

      Terblanche, E.; Stewart, R. I. (Health & Medical Publishing Group, 1990)
      Approximately 70-80% of all asthma sufferers develop acute airway obstruction with exercise, while at least 7% of children in the general population develop exercise-induced bronchoconstriction. The purpose of this study ...
    • Ischaemic postconditioning : from bench to bedside … 

      Van Vuuren, Derick; Lochner, Amanda (Clinics Cardiv Publishing, 2008-12)
      The increase in the incidence of ischaemic heart disease and acute myocardial infarction (AMI) in both high- and lowincome countries necessitates the development of myocardial salvaging/protection interventions, to be ...
    • Die kliniese belang van fosfolipiede longpatologie 

      Van Papendorp, D. H.; Engelbrecht, F. M. (Health & Medical Publishing Group, 1981)
      The phospholipid composition of 35 human lungs with pathological lesions was analysed by means of thin-layer chromatography and densitometric scanning. The pathological conditions studied were: bronchopneumonia, myocardial ...
    • Melatonin prevents cardioprotection induced by a multi-cycle ischaemic preconditioning protocol in the isolated perfused rat heart 

      Genade, S.; Ytrehus, K.; Lochner, A. (Clinics Cardiv Publishing, 2006-10)
      The powerful cardioprotective actions of melatonin, the chief secretory product of the pineal gland, have been attributed largely to its free radical-scavenging properties. Free radicals play an important role in the ...
    • Metabolic changes in the lungs after ischaemia 

      Engelbrecht, F. M.; Edwards, I. J.; De Beer, D. P. (Health & Medical Publishing Group, 1980)
      The effects of variable periods of ischaemia on the isolated lungs of rats and rabbits, stored for up to 6 hours at 4°C, 21°C and 37°C under standardized conditions, were investigated in vitro in terms of oxygen consumption, ...
    • Minimum Information About a Simulation Experiment (MIASE) 

      Waltemath, Dagmar; Adams, Richard (Public Library of Science (PLOS), 2011-04)
      Reproducibility of experiments is a basic requirement for science. Minimum Information (MI) guidelines have proved a helpful means of enabling reuse of existing work in modern biology. The Minimum Information Required in ...
    • Mycobactericidal activity of sutezolid (PNU-100480) in sputum (EBA) and blood (WBA) of patients with pulmonary tuberculosis 

      Wallis, Robert S.; Dawson, Rodney; Friedrich, Sven O.; Venter, Amour; Paige, Darcy; Zhu, Tong; Silvia, Annette; Gobey, Jason; Ellery, Craig; Zhang, Yao; Eisenach, Kathleen; Miller, Paul; Diacon, Andreas H. (PLoS, 2014-04-14)
      Rationale: Sutezolid (PNU-100480) is a linezolid analog with superior bactericidal activity against Mycobacterium tuberculosis in the hollow fiber, whole blood and mouse models. Like linezolid, it is unaffected by mutations ...
    • Myocardial susceptibility to ischaemia/reperfusion in obesity : a re-evaluation of the effects of age 

      Webster, I.; Salie, R.; Marais, E.; Fan, W. J.; Maarman, G.; Huisamen, B.; Lochner, A. (BioMed Central, 2017-03-17)
      Background Reports on the effect of age and obesity on myocardial ischaemia/reperfusion (I/R) injury and ischaemic preconditioning are contradictory. The aim of this study was to re-evaluate the effects of age and ...
    • New emphasis on atrial cardiology 

      Mouton, R.; Lochner, De J. V.; Lochner, A. (Health & Medical Publishing Group, 1992)
      Based on the concept that the cardiac muscle is differentiated mainly for excitation, conduction and contraction, cardiology has for many years focused mainly on the ventricles, with comparatively little attention to ...
    • A new trial design to accelerate tuberculosis drug development : the Phase IIC Selection Trial with Extended Post-treatment follow-up (STEP) 

      Phillips, Patrick P. J.; Dooley, Kelly E.; Gillespie, Stephen H.; Heinrich, Norbert; Stout, Jason E.; Nahid, Payam; Diacon, Andreas H.; Aarnoutse, Rob E.; Kibiki, Gibson S.; Boeree, Martin J.; Hoelscher, Michael (BioMed Central, 2016-03-23)
      Background: The standard 6-month four-drug regimen for the treatment of drug-sensitive tuberculosis has remained unchanged for decades and is inadequate to control the epidemic. Shorter, simpler regimens are urgently ...
    • Nutritional support in sepsis : when less may be more 

      Van Niekerk, Gustav; Meaker, Charne; Engelbrecht, Anna-Mart (BMC (part of Springer Nature), 2020-02-14)
      Despite sound basis to suspect that aggressive and early administration of nutritional support may hold therapeutic benefits during sepsis, recommendations for nutritional support have been somewhat underwhelming. ...
    • Phase 2b controlled trial of M72/AS01E vaccine to prevent tuberculosis 

      Van der Meeren, Olivier; Hatherill, Mark; Nduba, Videlis; Wilkinson, Robert J.; Muyoyeta, Monde; Van Brakel, Elana; Ayles, Helen M.; Henostroza, German; Thienemann, Friedrich; Scriba, Thomas J.; Diacon, Andreas; Blatner, Gretta L.; Demoitie, Marie-Ange; Tameris, Michele; Malahleha, Mookho; Innes, James C.; Hellstrom, Elizabeth; Martinson, Neil; Singh, Tina; Akite, Elaine J.; Khatoon Azam, Aisha; Bollaerts, Anne; Ginsberg, Ann M.; Evans, Thomas G.; Gillard, Paul; Tait, Dereck R. (Massachusetts Medical Society, 2018-10-25)
      BACKGROUND: A vaccine to interrupt the transmission of tuberculosis is needed. METHODS: We conducted a randomized, double-blind, placebo-controlled, phase 2b trial of the M72/AS01E tuberculosis vaccine in Kenya, South ...