Browsing Research Articles (Medical Physiology) by Title
Now showing items 14-33 of 54
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Cardiac glucolipotoxicity and cardiovascular outcomes
(MDPI, 2018)Cardiac insulin signaling can be impaired due to the altered fatty acid metabolism to induce insulin resistance. In diabetes and insulin resistance, the metabolic, structural and ultimately functional alterations in the ... -
Cardiomyocyte differentiation : experience and observations from 2 laboratories
(South African Heart Association, 2017)The undifferentiated clonal cell line, H9c2, derived from left ventricular rat heart tissue, has been extensively used in cardiovascular research. In the present study, 2 independent laboratories aimed to investigate the ... -
Cardioprotective potential of N-acetyl cysteine against hyperglycaemia-induced oxidative damage : a protocol for a systematic review
(BMC (part of Springer Nature), 2017)Background: Hyperglycaemia-induced oxidative damage is a well-established factor implicated in the development of diabetic cardiomyopathy (DCM) in diabetic individuals. Some of the well-known characteristics of DCM ... -
Cardiovascular risk and endothelial function in people living with HIV/AIDS: design of the multi-site, longitudinal EndoAfrica study in the Western Cape Province of South Africa
(BioMed Central, 2017-01-07)Background: There is growing evidence of an interaction between HIV-infection, anti-retroviral therapy (ART) and cardiovascular diseases (CVD). Epidemiological studies in Europe and North America have been observing a ... -
Combination of radiosensitizers and hyperthermia in tumour radiotherapy
(1981)Specific metabolic properties of hypoxic (and therefore radio-resistant) tumour cells are responsible for the selective effect of radiosensitizers (such as misonidazole) and hyperthermia upon these cells in respect of ... -
Creatine and exercise – strong evidence for stronger heart muscle
(American Society of Exercise Physiologists, 2011-10)There has been a dramatic increase in the use of dietary creatine supplementation among sports men and women, and by clinicians as a therapeutic agent in muscular and neurological diseases. The effects on skeletal muscles ... -
Critical appraisal of conventional semen analysis in the context of varicocele
(Frontiers Media, 2016)Varicocele is present in approximately 15% of men, and, although it is the most commonly diagnosed cause of male infertility, nearly two-thirds of men with varicoceles remain fertile. It was decided to make use of the ... -
Diabetes mellitus and male infertility
(Medknow, 2018)ENGLISH ABSTRACT: Infertility is prevalent in about 10%-25% of couples in their reproductive age, analogous to 60-80 million infertile couples globally. Of these infertility cases, 10%-30% are exclusively attributed to ... -
The effect of dietary red palm oil on the functional recovery of the ischaemic/reperfused isolated rat heart : the involvement of the PI3-Kinase signaling pathway
(BioMed Central, 2009-05)We have previously shown that dietary red palm oil (RPO) supplementation improves functional recovery in hearts subjected to ischaemia/reperfusion-induced injury. Unfortunately, the cellular and molecular mechanisms ... -
THE EFFECT OF LONG TERM SWIM TRAININ G ON PHYSIOLOGICA L STRESS LEVELS IN THE RAT
(The Society of Medical Laboratory Technologists of South Africa, 2010-12) -
Fenofibrate protects endothelial cells against the harmful effects of TNF-alpha
(South African Heart Association, 2017)Introduction: Fenofibrate exerts pleiotropic effects on endothelial cells (ECs) by, amongst others, increasing nitric oxide (NO) production. We aimed to investigate fenofi brate’s putative beneficial actions in healthy or ... -
High carbohydrate and high fat diets protect the heart against ischaemia/reperfusion injury
(BioMed Central Ltd., 2014-07-18)Background: Although obesity is still considered a risk factor in the development of cardiovascular disorders, recent studies suggested that it may also be associated with reduced morbidity and mortality, the so-called ... -
High fat programming and cardiovascular disease
(MDPI, 2018)ENGLISH ABSTRACT: Programming is triggered through events during critical developmental phases that alter offspring health outcomes. High fat programming is defined as the maintenance on a high fat diet during fetal and/or ... -
High resolution imaging study of interactions between the 37 kDa/67 kDa Laminin receptor and APP, beta-secretase and gamma-secretase in Alzheimer’s Disease
(PLoS, 2014-06-27)Alzheimer's disease (AD) is the most prevalent form of dementia affecting the elderly. Neurodegeneration is caused by the amyloid beta (Aβ) peptide which is generated from the sequential proteolytic cleavage of the Amyloid ... -
Influence of ejaculation frequency on seminal parameters
(BioMed Central, 2015-05-21)Background: Several factors have been shown to influence semen parameters, one of which is sexual abstinence; a clinical criteria included in the semen evaluation to provide maximum sperm quality. The aim of the present ... -
An investigation of excess residual cytoplasm in human spermatozoa and its distinction from the cytoplasmic droplet
(BioMed Cenral, 2012-11-17)Recent studies have shown cytoplasmic droplets to be normal morphological occurrences in human male spermatozoa. When the cytoplasm around the sperm midpiece is present in large amounts, however, pathological effects may ... -
Ischaemic postconditioning : from bench to bedside …
(Clinics Cardiv Publishing, 2008-12)The increase in the incidence of ischaemic heart disease and acute myocardial infarction (AMI) in both high- and lowincome countries necessitates the development of myocardial salvaging/protection interventions, to be ... -
Melatonin prevents cardioprotection induced by a multi-cycle ischaemic preconditioning protocol in the isolated perfused rat heart
(Clinics Cardiv Publishing, 2006-10)The powerful cardioprotective actions of melatonin, the chief secretory product of the pineal gland, have been attributed largely to its free radical-scavenging properties. Free radicals play an important role in the ... -
Minimum Information About a Simulation Experiment (MIASE)
(Public Library of Science (PLOS), 2011-04)Reproducibility of experiments is a basic requirement for science. Minimum Information (MI) guidelines have proved a helpful means of enabling reuse of existing work in modern biology. The Minimum Information Required in ... -
Mycobactericidal activity of sutezolid (PNU-100480) in sputum (EBA) and blood (WBA) of patients with pulmonary tuberculosis
(PLoS, 2014-04-14)Rationale: Sutezolid (PNU-100480) is a linezolid analog with superior bactericidal activity against Mycobacterium tuberculosis in the hollow fiber, whole blood and mouse models. Like linezolid, it is unaffected by mutations ...
