Browsing Research Articles (Medical Physiology) by Title
Now showing items 16-35 of 83
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Cancer : approaching a universal molecular mechanism?
(Health & Medical Publishing Group, 1990)Accumulating evidence strongly suggests that cancer is a genetic disease, arising from mutations in DNA. These mutations alter the function or synthesis of two groups of proteins, which are the products of either proto-oncogenes ... -
Cardiac glucolipotoxicity and cardiovascular outcomes
(MDPI, 2018)Cardiac insulin signaling can be impaired due to the altered fatty acid metabolism to induce insulin resistance. In diabetes and insulin resistance, the metabolic, structural and ultimately functional alterations in the ... -
Cardiomyocyte differentiation : experience and observations from 2 laboratories
(South African Heart Association, 2017)The undifferentiated clonal cell line, H9c2, derived from left ventricular rat heart tissue, has been extensively used in cardiovascular research. In the present study, 2 independent laboratories aimed to investigate the ... -
Cardioprotective potential of N-acetyl cysteine against hyperglycaemia-induced oxidative damage : a protocol for a systematic review
(BMC (part of Springer Nature), 2017)Background: Hyperglycaemia-induced oxidative damage is a well-established factor implicated in the development of diabetic cardiomyopathy (DCM) in diabetic individuals. Some of the well-known characteristics of DCM ... -
Cardiovascular risk and endothelial function in people living with HIV/AIDS: design of the multi-site, longitudinal EndoAfrica study in the Western Cape Province of South Africa
(BioMed Central, 2017-01-07)Background: There is growing evidence of an interaction between HIV-infection, anti-retroviral therapy (ART) and cardiovascular diseases (CVD). Epidemiological studies in Europe and North America have been observing a ... -
Combination of radiosensitizers and hyperthermia in tumour radiotherapy
(1981)Specific metabolic properties of hypoxic (and therefore radio-resistant) tumour cells are responsible for the selective effect of radiosensitizers (such as misonidazole) and hyperthermia upon these cells in respect of ... -
Creatine and exercise – strong evidence for stronger heart muscle
(American Society of Exercise Physiologists, 2011-10)There has been a dramatic increase in the use of dietary creatine supplementation among sports men and women, and by clinicians as a therapeutic agent in muscular and neurological diseases. The effects on skeletal muscles ... -
Critical appraisal of conventional semen analysis in the context of varicocele
(Frontiers Media, 2016)Varicocele is present in approximately 15% of men, and, although it is the most commonly diagnosed cause of male infertility, nearly two-thirds of men with varicoceles remain fertile. It was decided to make use of the ... -
Diabetes mellitus and male infertility
(Medknow, 2018)ENGLISH ABSTRACT: Infertility is prevalent in about 10%-25% of couples in their reproductive age, analogous to 60-80 million infertile couples globally. Of these infertility cases, 10%-30% are exclusively attributed to ... -
DNA methylation of FKBP5 in South African women : associations with obesity and insulin resistance
(BMC (part of Springer Nature), 2020-09-21)Background: Disruption of the hypothalamic–pituitary–adrenal (HPA) axis, a neuroendocrine system associated with the stress response, has been hypothesized to contribute to obesity development. This may be mediated through ... -
The effect of corticosteroid therapy on lysosomal enzymes and protein and lipid metabolism in rabbit lung after administration of Freund's adjuvant
(Health & Medical Publishing Group, 1982)The effect of corticosteroid therapy on the bronchoalveolar cell response, the changes in activity of some lysosomal enzymes and the protein and lipid biosynthesis rates in lung tissue of normal rabbits and of rabbits after ... -
The effect of dietary red palm oil on the functional recovery of the ischaemic/reperfused isolated rat heart : the involvement of the PI3-Kinase signaling pathway
(BioMed Central, 2009-05)We have previously shown that dietary red palm oil (RPO) supplementation improves functional recovery in hearts subjected to ischaemia/reperfusion-induced injury. Unfortunately, the cellular and molecular mechanisms ... -
THE EFFECT OF LONG TERM SWIM TRAININ G ON PHYSIOLOGICA L STRESS LEVELS IN THE RAT
(The Society of Medical Laboratory Technologists of South Africa, 2010-12) -
The effect of oxygen and paraquat on the 14C-glucose oxidation of rabbit alveolar macrophages and lung slices
(Health & Medical Publishing Group, 1979)In this study, we measured the effects of different concentrations of paraquat (0.01 mM and 1.0 mM) on the 1-14CO2 and 6-14CO2 production of rabbit lung slices and isolated alveolar macrophages, in 20% and 95% oxygen phases ... -
The effect of paraquat on the aerobic metabolism of rabbit alveolar macrophages and lung fibroblasts
(Health & Medical Publishing Group, 1979)In this study the effects of paraquat on the aerobic metabolism and viability of isolated rabbit alveolar macrophages and lung fibroblasts were investigated, and compared with the effects of other known metabolic inhibitors, ... -
The effect of paraquat on the in vitro activity of cytosol, mitochondrial and microsomal enzyme systems
(Health & Medical Publishing Group, 1984)Subcellular fractions (mitochondria, microsomes and cytosol) were prepared from the lungs of rabbits and rats to investigate the effects of paraquat (Aldrich Laboratories) on the activity of cytosol and mitochondrial ... -
The effect of paraquat on the incorporation of radiolabelled proline into acid-extractable lung proteins and collagens
(Health & Medical Publishing Group, 1982)In this comparative study the authors describe the influence of paraquat on the rate of L-2,3-3H proline incorportion into the acid-extractable proteins and into newly synthesized protropocollagen molecules from the lungs ... -
The effect of paraquat on the incorporatipon of 14C-leucine and 14C-palmitate into lung proteins and lung lipids of rats and rabbits
(Health & Medical Publishing Group, 1981)The results of this comparative study show that paraquat added in vitro inhibited lipid and protein biosynthesis by lung slices from rats and rabbits during the first 2 hours of incubation. This inhibition was maintained ... -
Exercise in patients with chronic obstructive pulmonary disease
(Health & Medical Publishing Group, 1985)Patients with chronic obstructive pulmonary disease (COPD) may incur exercise limitation by any one or combination of disturbances in breathing mechanics, oxygen transport, respiratory muscle metabolism or respiratory ... -
Experimental evaluation of the prophylactic and therapeutic effects of hydrocortisone in haemorrhagic shock
(Health & Medical Publishing Group, 1985)The prophylactic and therapeutic effects of hydrocortisone (50mg/kg) in severe haemorrhagic shock were evaluated by metabolic, biochemical and haematological investigations in a rabbit model. It was found that administration ...
