Browsing Research Articles (Medical Physiology) by Title
Now showing items 1-20 of 83
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The adrenal cortex in hypercholesterolaemic rabbits. Histochemical and electron microscopical changes
(Health & Medical Publishing Group, 1978-2)The adrenals of rabbits on a cholesterol-rich diet for 35 days showed histopathological changes, a marked increase in weight and a lowering in the ascorbate content. A focal increase in the neutral lipid and cholesterol ... -
Ameliorative potentials of quercetin against cotinine-induced toxic effects on human spermatozoa
(Hainan Medical University Journal Publisher, 2016)Objectives: Cotinine, the principal metabolite of nicotine found in smokers' seminal plasma, has been shown to adversely affect sperm functionality while quercetin, a flavonoid with diverse properties is associated with ... -
AMP kinase activation and glut4 translocation in isolated cardiomyocytes
(Clinics Cardive Publishing, 2010-04)Activation of AMP-activated protein kinase (AMPK) results in glucose transporter 4 (GLUT4) translocation from the cytosol to the cell membrane, and glucose uptake in the skeletal muscles. This increased activation of AMPK ... -
AMP kinase activation and glut4 translocation in isolated cardiomyocytes
(http://www.cvja.co.za/index.php, 2010-03) -
Antioxidant activities of Basella alba aqueous leave extract in blood, pancreas, and gonadal tissues of diabetic male Wistar rats
(Wolters Kluwer, 2018)Background: Oxidative stress is frequently identified as a key element in the pathophysiology of many complications of diabetes mellitus, including reproductive complications. The antioxidant potential of medicinal ... -
Ascorbic acid causes spuriously low blood glucose measurements
(Health & Medical Publishing Group, 1993-01)[No abstract available] -
Aspalathin reverts doxorubicin-induced cardiotoxicity through increased autophagy and decreased expression of p53/mTOR/p62 signaling
(MDPI, 2017-11-01)ENGLISH ABSTRACT: Doxorubicin (Dox) is an effective chemotherapeutic agent used in the treatment of various cancers. Its clinical use is often limited due to its potentially fatal cardiotoxic side effect. Increasing evidence ... -
Aspalathin, a C-glucosyldihydrochalcone from rooibos improves the hypoglycemic potential of metformin in type 2 diabetic (db/db) mice
(Institute of Physiology, The Czech Academy of Sciences, 2018-07-25)ENGLISH ABSTRACT: Metformin is the first line therapy of type 2 diabetics, but continued reduction of their life expectancy warrants further investigation into alternative treatment strategies. This study reports on the ... -
Assessment of the 2,4 km run as a predictor of aerobic capacity
(Health & Medical Publishing Group, 1990-09)ENGLISH ABSTRACT: Since the 2,4 km run time test is routinely used in military training programmes as an indicator of aerobic capacity and its possible improvement, an atemtp was made to: (i) establish a regression equation ... -
Ataxia-Telangiectasia Mutated is located in cardiac mitochondria and impacts oxidative phosphorylation
(Springer Nature, 2019)The absence of Ataxia-Telangiectasia mutated protein kinase (ATM) is associated with neurological, metabolic and cardiovascular defects. The protein has been associated with mitochondria and its absence results in mitochondrial ... -
Beneficial effects of adenosine triphosphate-MgC12 administered intravenously to rabbits subjected to haemorrhagic shock
(Health & Medical Publishing Group, 1986-10)ENGLISH ABSTRACT: The beneficial effects of adenosine triphosphate (ATP)-MgCl2 administered as a bolus following fluid infusion or in combination with the infusion fluid were investigated in rabbits subjected to severe but ... -
Biochemiese en Hematologiese Veranderinge Tydens Eksperimentele Hipercholesterolemie
(Health & Medical Publishing Group, 1973-11)ENGLISH ABSTRACT: Various biochemical and hematological parameters were investigated during experimentally induced hypercholesterolemia in rabbits. A close correlation between the total serum cholesterol concentration and ... -
Biological effect of asbestos dust on the peritoneal viscera of rats
(Health & Medical Publishing Group, 1973-09)ENGLISH ABSTRACT: Crocidolite and chrysotile asbestos suspensions were ip injected into rats. Peritoneal mesotheliomas were induced in 90% of the crocidolite group and in 30% of the chrysotile group. The pathology and ... -
Blood-based DNA methylation biomarkers for type 2 diabetes : potential for clinical applications
(Frontiers Media, 2018)ENGLISH ABSTRACT: Type 2 diabetes (T2D) is a leading cause of death and disability worldwide. It is a chronic metabolic disorder that develops due to an interplay of genetic, lifestyle, and environmental factors. The ... -
Body composition in women with HIV/AIDS : the relevance of exercise
(Health and Medical Publishing Group (HMPG), 2008-07)Untreated infection with the human immunodeficiency virus (HIV) leads to severe physical debilitation, culminating in the acquired immune deficiency syndrome (AIDS). Multiple infections, body mass loss, physical weakness ... -
Cancer : approaching a universal molecular mechanism?
(Health & Medical Publishing Group, 1990)Accumulating evidence strongly suggests that cancer is a genetic disease, arising from mutations in DNA. These mutations alter the function or synthesis of two groups of proteins, which are the products of either proto-oncogenes ... -
Cardiac glucolipotoxicity and cardiovascular outcomes
(MDPI, 2018)Cardiac insulin signaling can be impaired due to the altered fatty acid metabolism to induce insulin resistance. In diabetes and insulin resistance, the metabolic, structural and ultimately functional alterations in the ... -
Cardiomyocyte differentiation : experience and observations from 2 laboratories
(South African Heart Association, 2017)The undifferentiated clonal cell line, H9c2, derived from left ventricular rat heart tissue, has been extensively used in cardiovascular research. In the present study, 2 independent laboratories aimed to investigate the ... -
Cardioprotective potential of N-acetyl cysteine against hyperglycaemia-induced oxidative damage : a protocol for a systematic review
(BMC (part of Springer Nature), 2017)Background: Hyperglycaemia-induced oxidative damage is a well-established factor implicated in the development of diabetic cardiomyopathy (DCM) in diabetic individuals. Some of the well-known characteristics of DCM ... -
Cardiovascular risk and endothelial function in people living with HIV/AIDS: design of the multi-site, longitudinal EndoAfrica study in the Western Cape Province of South Africa
(BioMed Central, 2017-01-07)Background: There is growing evidence of an interaction between HIV-infection, anti-retroviral therapy (ART) and cardiovascular diseases (CVD). Epidemiological studies in Europe and North America have been observing a ...
