• Best practices and innovations for managing codeine misuse and dependence 

      Norman, Ian J.; Bergin, Michael; Parry, Charles D.; Van Hout, Marie-Claire (Canadian Society for Pharmaceutical Sciences, 2016-10-27)
      Purpose: Promoting and ensuring safe use of codeine containing medicines remains a public health issue given the rise in reporting of misuse and dependence particularly in countries where available over–the-counter (OTC). ...
    • Big effects of small RNAs : a review of MicroRNAs in anxiety 

      Malan-Muller, Stephanie; Hemmings, Sian M. J.; Seedat, Soraya (SpringerLink, 2012-11)
      Epigenetic and regulatory elements provide an additional layer of complexity to the heterogeneity of anxiety disorders. MicroRNAs (miRNAs) are a class of small, noncoding RNAs that have recently drawn interest as ...
    • Body dysmorphic disorder : a diagnostic challenge in adolescence 

      Thungana, Yanga; Moxley, Karis; Lachman, Anusha (AOSIS, 2018)
      Body dysmorphic disorder (BDD) is a chronic and disabling condition that is characterised by distressing preoccupations with perceived defects in one’s own appearance, which might be slight or not observable to others. It ...
    • Brain-derived neurotrophic factor (BDNF) protein levels in anxiety disorders : systematic review and meta-regression analysis 

      Suliman, Sharain; Hemmings, Sian M. J.; Seedat, Soraya (Frontiers, 2013-07)
      Background: Brain-Derived Neurotrophic Factor (BDNF) is a neurotrophin that is involved in the synaptic plasticity and survival of neurons. BDNF is believed to be involved in the pathogenesis of several neuropsychiatric ...
    • The burden of mental disorders in the Eastern Mediterranean Region, 1990-2013 

      Charara, Raghid; Forouzanfar, Mohammad; Naghavi, Mohsen; Moradi-Lakeh, Maziar; Afshin, Ashkan; Vos, Theo; Daoud, Farah; Wang, Haidong; El Bcheraoui, Charbel; Khalil, Ibrahim; Hamadeh, Randah R.; Khosravi, Ardeshir; Rahimi-Movaghar, Vafa; Khader, Yousef; Al-Hamad, Nawal; Obermeyer, Carla Makhlouf; Rafay, Anwar; Asghar, Rana; Rana, Saleem M.; Shaheen, Amira; Abu-Rmeileh, Niveen M. E.; Husseini, Abdullatif; Abu-Raddad, Laith J.; Khoja, Tawfik; Al Rayess, Zulfa A.; AlBuhairan, Fadia S.; Hsairi, Mohamed; Alomari, Mahmoud A.; Ali, Raghib; Roshandel, Gholamreza; Terkawi, Abdullah Sulieman; Hamidi, Samer; Refaat, Amany H.; Westerman, Ronny; Kiadaliri, Aliasghar Ahmad; Akanda, Ali S.; Ali, Syed Danish; Bacha, Umar; Badawi, Alaa; Bazargan-Hejazi, Shahrzad; Faghmou, Imad A. D.; Fereshtehnejad, Seyed-Mohammad; Fischer, Florian; Jonas, Jost B.; Defo, Barthelemy Kuate; Mehari, Alem; Omer, Saad B.; Pourmalek, Farshad; Uthman, Olalekan A.; Mokdad, Ali A.; Maalouf, Fadi T.; Abd-Allah, Foad; Akseer, Nadia; Arya, Dinesh; Borschmann, Rohan; Brazinova, Alexandra; Brugha, Traolach S.; Catala-Lopez, Ferran; Degenhardt, Louisa; Ferrari, Alize; Haro, Josep Maria; Horino, Masako; Hornberger, John C.; Huang, Hsiang; Kieling, Christian; Kim, Daniel; Kim, Yunjin; Knudsen, Ann Kristin; Mitchell, Philip B.; Patton, George; Sagar, Rajesh; Satpathy, Maheswar; Savuon, Kim; Seedat, Soraya; Shiue, Ivy; Skogen, Jens Christoffer; Stein, Dan J.; Tabb, Karen M.; Whiteford, Harvey A.; Yip, Paul; Yonemoto, Naohiro; Murray, Christopher J. L.; Mokdad, Ali H. (Public Library of Science, 2017)
      The Eastern Mediterranean Region (EMR) is witnessing an increase in chronic disorders, including mental illness. With ongoing unrest, this is expected to rise. This is the first study to quantify the burden of mental ...
    • Cannabis use and abuse correlates in a homogeneous South African schizophrenia population 

      Koen, L.; Jonathan, R.; Niehaus, D. J. H. (AOSIS Publishing, 2009-03-01)
      Objective. Worldwide, cannabis is the most widely used illicit substance, and it has been identified as a correlate in schizophrenia samples for poorer symptomatic and functional outcomes in many international studies. The ...
    • A case of Ifufunyane : a Xhosa culture-bound syndrome 

      Niehaus, Dana J. H.; Stein, Dan J.; Koen, Liezl; Lochner, Christine; Muller, Jacqueline E.; Mbanga, N. Irene; Emsley, Robin A. (Lippincott, Williams & Wilkins, 2005-11)
      Clinicians and patients frequently have a different understanding and interpretation of the nature of an illness. While many reasons for these discrepancies can be postulated, differences in sociocultural background often ...
    • Chromosome 22q11 in a Xhosa schizophrenia population 

      Koen, Liezl; Niehaus, Dana J. H.; Wright, Galen; Warnich, Louise; De Jong, Greetje; Emsley, Robin A.; Mall, Sumaya (Health and Medical Publishing Group (HMPG), 2012-03)
      Chromosome 22q11 aberrations substantially increase the risk for developing schizophrenia. Although micro-deletions in this region have been extensively investigated in different populations across the world, little is ...
    • Cigarette smoking, nicotine dependence, and motivation to quit smoking in South African male psychiatric inpatients 

      Du Plooy, Jean-Louis; Macharia, Muiruri (BioMed Central, 2016-11)
      Background: Smoking is the leading cause of preventable death worldwide and the prevalence is particularly high among psychiatric patients but recent international studies demonstrated that psychiatric patients are able ...
    • Clinical and neuropsychological predictors of posttraumatic stress disorder 

      Suliman, Sharain; Stein, Dan J.; Seedat, Soraya (Lippincott, Williams & Wilkins, 2014-11)
      Abstract: Although acute responses to traumatic stress generally resolve within a few weeks, some individuals experience severe and persistent problems, such as posttraumatic stress disorder (PTSD). While studies have ...
    • A clinical approach to the assessment and management of co-morbid eating disorders and substance use disorders 

      Gregorowski, Claire; Seedat, Soraya; Jordaan, Gerhard P. (BioMed Central, 2013-11)
      Introduction: Research has shown that eating disorder (ED) patients who abuse substances demonstrate worse ED symptomatology and poorer outcomes than those with EDs alone, including increased general medical complications ...
    • A cluster randomised controlled trial protocol of an adapted intervention for alcohol use disorders in people living with HIV and AIDS : impact on alcohol use, general functional ability, quality of life and adherence to HAART 

      Madhombiro, Munyaradzi; Dube-Marimbe, Bazondlile; Dube, Michelle; Chibanda, Dixon; Zunza, Moleen; Rusakaniko, Simbarashe; Stewart, David; Seedat, Soraya (BioMed Central, 2017-01-28)
      ENGLISH SUMMARY : Background: Interventions for alcohol use disorders (AUDs) in HIV infected individuals have been primarily targeted at HIV risk reduction and improved antiretroviral treatment adherence. However, reduction ...
    • Co-occurrence of schizophrenia and obsessive compulsive disorder : a literature review 

      Emsley, R. A.; Stein, D. J.; Oosthuizen, P. (Health & Medical Publishing Group, 1999)
      [No abstract available]
    • Codeine misuse and dependence in South Africa : learning from substance abuse treatment admissions 

      Dada, S.; Burnhams, N. Harker; Van Hout, M. C.; Parry, C. D. H. (Health & Medical Publishing Group, 2015)
      Background: Misuse of prescription and over-the-counter codeine-containing products is a global public health issue. Objectives: To investigate the extent of treatment demand related to the misuse of codeine or codeine ...
    • Codeine misuse and dependence in South Africa : perspectives of addiction treatment providers 

      Parry, C. D. H.; Rich, E.; Van Hout, M. C.; Deluca, P. (Health and Medical Publishing Group, 2017)
      Background. General practitioners are referring patients with codeine-related problems to specialist treatment facilities, but little is known about the addiction treatment providers, the kinds of treatment they provide, ...
    • Cognitive changes in alcohol-induced psychotic disorder 

      Hendricks, Melany L.; Emsley, R. A.; Nel, D. G.; Thornton, H. B.; Jordaan, G. P. (BioMed Central, 2017-04)
      ENGLISH SUMMARY : Aims: This study aimed to explore the neuro-cognitive deficits of alcohol-induced psychotic disorder as compared to the cognitive deficits of uncomplicated alcohol ependence. Methods: Participants were ...
    • Cognitive-perceptual deficits and symptom correlates in first-episode schizophrenia 

      Olivier, Riaan M.; Kilian, Sanja; Chiliza, Bonginkosi; Asmal, Laila; Oosthuizen, Petrus P.; Emsley, Robin A.; Kidd, Martin (AOSIS Publishing, 2017)
      Background: Thought disorder and visual-perceptual deficits have been well documented, but their relationships with clinical symptoms and cognitive function remain unclear. Cognitive-perceptual deficits may underscore ...
    • Collaborative shared care to improve psychosis outcome (COSIMPO) : study protocol for a randomized controlled trial 

      Gureje, Oye; Makanjuola, Victor; Kola, Lola; Yusuf, Bidemi; Price, Leshawndra; Esan, Oluyomi; Oladeji, Bibilola D.; Appiah-Poku, John; Haris, Benjamin; Othieno, Caleb; Seedat, Soraya (BioMed Central, 2017-10)
      Background: Psychotic disorders are a group of severe mental disorders that cause considerable disability to sufferers and a high level of burden to families. In many low- and middle-income countries (LMIC), traditional ...
    • A comparative analysis of pharmacists’ perspectives on codeine use and misuse – a three country survey 

      Carney, Tara; Wells, John; Parry, Charles D. H.; McGuinness, Padraig; Harris, Richard; Van Hout, Marie Claire (BioMed Central, 2018-03-27)
      Background: The misuse of codeine is of increasing concern in a number of countries, particularly as this relates to over -the-counter pain and cough relief medication, and is also supplied as a prescription medicine. The ...
    • Comparison of pain, cortisol levels, and psychological distress in women undergoing surgical termination of pregnancy under local anaesthesia versus intravenous sedation 

      Suliman, Sharain; Ericksen, Todd; Labuschgne, Peter W.; De Wit, Renee; Stein, Dan J.; Seedat, Soraya (BioMed Central, 2007-06)
      Background: The weight of evidence suggests that women who freely choose to terminate a pregnancy are unlikely to experience significant mental health risks, however some studies have documented psychological distress in ...