Browsing Research Articles (Physiological Sciences) by Title
Now showing items 1-20 of 81
-
Amino acid starvation sensitizes resistant breast cancer to doxorubicin-induced cell death
(Frontiers Media, 2020)Many clinical trials are beginning to assess the effectiveness of compounds known to regulate autophagy in patients receiving anti-cancer chemotherapy. However, autophagy inhibition, through exogenous inhibitors, or ... -
Anti-inflammatory cellular targets on neutrophils elucidated using a novel cell migration model and confocal microscopy : a clinical supplementation study
(BioMed Central, 2018-01-05)Background In vivo studies have shown grape seed-derived polyphenols (GSP) to benefit in recovery from muscle injury by modulation of neutrophil infiltration into damaged tissue, thereby reducing secondary ... -
Aspalathin protects the heart against hyperglycemia-induced oxidative damage by up-regulating Nrf2 expression
(MDPI, 2017)Aspalathin (ASP) can protect H9c2 cardiomyocytes against high glucose (HG)-induced shifts in myocardial substrate preference, oxidative stress, and apoptosis. The protective mechanism of ASP remains unknown. However, as ... -
Assessment of endocrine stress status in athletes – new twists to the tale
(Health and Medical Publishing Group, 2005)Objective. Cortisol concentration at rest seems to be an insensitive marker for endocrine stress status in athletes. Therefore, the aim of this review was to identify potentially more sensitive parameters which could ... -
Bcl‑2 confers survival in cisplatin treated cervical cancer cells: circumventing cisplatin dose‑dependent toxicity and resistance
(BioMed Central, 2015-10)Background: Cisplatin is the main chemotherapeutic drug for the treatment of cervical cancers, however resistance to cisplatin is increasingly common and therefore has limited the efficacy and use of this drug in the ... -
Bone mineral density in people living with HIV : a narrative review of the literature
(BioMed Central, 2017-07-26)Bone health status is largely absent in South Africa, the main reasons being the absence and cost-effectiveness of specific screening equipment for assessing bone mineral density (BMD). Various risk factors seem to play a ... -
C-reactive protein is elevated only in high creatine kinase responders to muscle damaging exercise
(Frontiers Media, 2017-02-11)The purpose of this study was to investigate if exertional rhabdomyolysis induced by an acute bout of plyometric exercise in untrained individuals was associated with histological characteristics of skeletal muscle, creatine ... -
Cardio-metabolic effects of HIV protease inhibitors (Lopinavir/Ritonavir)
(PLoS, 2013-11)Although antiretroviral treatment decreases HIV-AIDS morbidity/mortality, long-term side effects may include the onset of insulin resistance and cardiovascular diseases. However, the underlying molecular mechanisms responsible ... -
Central intracrine DHEA synthesis in ageing-related neuroinflammation and neurodegeneration : therapeutic potential?
(BMC (part of Springer Nature), 2018-10-16)It is a well-known fact that DHEA declines on ageing and that it is linked to ageing-related neurodegeneration, which is characterised by gradual cognitive decline. Although DHEA is also associated with inflammation in ... -
Chemoresistance : intricate interplay between breast tumor cells and adipocytes in the tumor microenvironment
(Frontiers Media, 2018-12-11)Excess adipose tissue is a hallmark of an overweight and/or obese state as well as a primary risk factor for breast cancer development and progression. In an overweight/obese state adipose tissue becomes dysfunctional due ... -
Chronic gestational inflammation : transfer of maternal adaptation over two generations of progeny
(Hindawi, 2019-08-25)Changes in the in utero environment result in generational transfer of maladapted physiology in the context of conditions such as stress, obesity, and anxiety. Given the significant contribution of noncommunicable ... -
Colorectal cancer is associated with increased circulating lipopolysaccharide, inflammation and hypercoagulability
(Nature Research (part of Springer Nature), 2020-05-29)Gut dysbiosis contributes to the development of a dysfunctional gut barrier, facilitating the translocation of bacteria and inflammagens, and is implicated in colorectal cancer (CRC) pathogenesis. Such ‘leaky gut’ conditions ... -
Commentary on : "A common origin for immunity and digestion"
(Frontiers Media, 2015-05)No abstract -
Comparison of pathological clotting using haematological, functional and morphological investigations in HIV-positive and HIV-negative patients with deep vein thrombosis
(BioMed Central, 2020-06-22)Background: Patients infected with the human immunodeficiency virus (HIV) are more prone to systemic inflammation and pathological clotting, and many may develop deep vein thrombosis (DVT) as a result of this dysregulat ... -
Coordinated autophagy modulation overcomes glioblastoma chemoresistance through disruption of mitochondrial bioenergetics
(Nature Research, 2018-07-09)Glioblastoma Multiforme (GBM) is known to be one of the most malignant and aggressive forms of brain cancer due to its resistance to chemotherapy. Recently, GBM was found to not only utilise both oxidative phosphorylation ... -
Correlative Light-Electron Microscopy detects lipopolysaccharide and its association with fibrin fibres in Parkinson’s Disease, Alzheimer’s Disease and Type 2 Diabetes Mellitus
(Nature Research, 2018-11-14)Many chronic diseases, including those classified as cardiovascular, neurodegenerative, or autoimmune, are characterized by persistent inflammation. The origin of this inflammation is mostly unclear, but it is typically ... -
Covid-19 : the rollercoaster of fibrin(ogen), D-dimer, Von Willebrand Factor, P-selectin and their interactions with endothelial cells, platelets and erythrocytes
(MDPI, 2020-07-21)Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), also known as coronavirus disease 2019 (COVID-19)-induced infection, is strongly associated with various coagulopathies that may result in either bleeding and ... -
Decreased efficacy of doxorubicin corresponds with modifications in lipid metabolism markers and fatty acid profiles in breast tumors from obese vs. lean mice
(Frontiers Media, 2018-03-17)Breast cancer cells modulate lipid and fatty acid metabolism to sustain proliferation. The role of adipocytes in cancer treatment efficacy remains, however, to be fully elucidated. We investigated whether diet-induced ... -
A dietary survey of free living middle aged White males in the Western Cape
(Health and Medical Publishing Group (HMPG), 1974)[No abstract available] -
Distinct gender differences in anthropometric profiles of a peri-urban South African HIV population : a cross sectional study
(BioMed Central, 2015-02)Background: Highly active antiretroviral therapy (HAART) has extended life expectancy and enhanced the well-being of HIV-positive individuals. Since there are concerns regarding HAART-mediated onset of cardio-metabolic ...
