Now showing items 1-5 of 5
Investigating the role of gene-gene interactions in TB susceptibility
(Public Library of Science, 2015-04)
Tuberculosis (TB) is the second leading cause of mortality from infectious disease worldwide. One of the factors involved in developing disease is the genetics of the host, yet the field of TB susceptibility genetics has ...
Genetic resistance to mycobacterium tuberculosis infection and disease
(Frontiers Media, 2017)
Natural history studies of tuberculosis (TB) have revealed a spectrum of clinical outcomes after exposure to Mycobacterium tuberculosis, the cause of TB. Not all individuals exposed to the bacterium will become diseased ...
Exome sequencing identifies a novel MAP3K14 mutation in recessive atypical combined immunodeficiency
ENGLISH ABSTRACT: Primary immunodeficiency disorders (PIDs) render patients vulnerable to infection with a wide range of microorganisms and thus provide good in vivo models for the assessment of immune responses during ...
A sex-stratified genome-wide association study of tuberculosis using a multi-ethnic genotyping array
(Frontiers Media, 2019)
Tuberculosis (TB), caused by Mycobacterium tuberculosis, is a complex disease with a known human genetic component. Males seem to be more affected than females and in most countries the TB notification rate is twice as ...
The X chromosome and sex-specific effects in infectious disease susceptibility
(BMC (part of Springer Nature), 2019-01-08)
ENGLISH ABSTRACT: The X chromosome and X-linked variants have largely been ignored in genome-wide and candidate association studies of infectious diseases due to the complexity of statistical analysis of the X chromosome. ...