• Modeling HIV-1 drug resistance as episodic directional selection 

      Murrell, Ben; De Oliveira, Tulio; Seebregts, Chris; Pond, Sergei L. Kosakovsky; Scheffler, Konrad (PLOS Computational Biology, 2011-05)
      The evolution of substitutions conferring drug resistance to HIV-1 is both episodic, occurring when patients are on antiretroviral therapy, and strongly directional, with site-specific resistant residues increasing in ...