Author
Now showing items 1-1 of 1
-
Modeling HIV-1 drug resistance as episodic directional selection
Murrell, Ben; De Oliveira, Tulio; Seebregts, Chris; Pond, Sergei L. Kosakovsky; Scheffler, Konrad (PLOS Computational Biology, 2011-05)The evolution of substitutions conferring drug resistance to HIV-1 is both episodic, occurring when patients are on antiretroviral therapy, and strongly directional, with site-specific resistant residues increasing in ...