Sepsis : at-risk patients, clinical manifestations and management
The original publication is available at http://www.cmej.org.za/index.php/cmej
Sepsis is a major clinical challenge, especially to clinicians working in emergency and critical care units. Research over the last decade into a better understanding of the pathophysiology and management of sepsis has resulted in a remarkable increase of new knowledge on the subject. Some findings translate into improved outcomes, while others lack reproducibility in large clinical trials.