Masters Degrees (Biochemistry): Recent submissions
Now showing items 1-20 of 148
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Modular control analysis and its application to glucose metabolism in plasmodium falciparum-infected erythrocytes
(Stellenbosch : Stellenbosch University, 2021-12)ENGLISH ABSTRACT: Disease treatment is achieved through the administration of medication acting at the molecular level which results in changes at the physiological level. These changes are caused by molecular interactions ... -
The role of a positive feedforward loop in regulating yeast glycolytic intermediate dynamics
(Stellenbosch : Stellenbosch University, 2021-12)ENGLISH ABSTRACT: Yeast glycolysis is a well-studied model for metabolic pathways and fundamental aspects of regulation. Whereas negative feedback is common in metabolic networks; positive feedforward regulation is much ... -
Phasor representation of oscillatory biochemical pathways
(Stellenbosch : Stellenbosch University, 2021-12)ENGLISH ABSTRACT: Oscillations or rhythms arise in many biological systems such as biochemical pathways. Numerous mathematical models and experimental data sets of such systems display sustained oscillations in both the ... -
On the relationship between thermodynamic disequilibrium ratio and flux control of metabolic pathways
(Stellenbosch : Stellenbosch University, 2021-12)ENGLISH ABSTRACT: This study presents a methodology to determine and compare flux control co- efficients, as defined in the metabolic control analysis framework, with dise- quilibrium ratios of reactions in metabolic ... -
Investigating the effects of treatment in HIV disease models
(Stellenbosch : Stellenbosch University, 2021-12)ENGLISH ABSTRACT: HIV/AIDS and disease response to antiretroviral (ARV ) drugs are of major importance to the developing world, and the disease remains a burden on society, as viral replication still needs to be ... -
Examining plasminogen activator-inhibitor-1 and C-reactive protein regulation by glucocorticoids and pro-inflammatory cytokines in liver cell lines
(Stellenbosch : Stellenbosch University, 2021-12)ENGLISH ABSTRACT: Current knowledge suggests that a continued elevated acute phase response (APR), which is often referred to as low-grade inflammation, occurs during insulin resistance. The levels of acute phase ... -
Examining the transcription factor FOXO1 and its regulation by glucocorticoids and inflammatory mediators in hepatic insulin signalling
(Stellenbosch : Stellenbosch University, 2021-12)ENGLISH ABSTRACT: Insulin resistance is the decrease in responsiveness to normal circulating insulin levels, resulting in an attenuated biological response in target tissues (including the liver, muscle, ... -
Quantitation of the effects of cellular glucocorticoid receptor concentration on dimerization
(Stellenbosch : Stellenbosch University, 2021-04)ENGLISH ABSTRACT: The glucocorticoids (GCs) are a group of steroids affecting virtually every cell in the body. The ability of the GCs to modulate the effects of the immune system is of particular interest ... -
Antibody production against Staphylococcus aureus CoA biosynthesis enzymes and their application in protein level quantification
(Stellenbosch : Stellenbosch University, 2021-04)ENGLISH ABSTRACT: Antimicrobial resistance has become an increased burden worldwide as more and more human pathogens are becoming resistant to current antimicrobials. Therefore, the identification of novel drug targets and ... -
Co-regulation of insulin signalling by glucocorticoids and pro-inflammatory cytokines
(Stellenbosch : Stellenbosch University, 2021-04)ENGLISH ABSTRACT: In the liver, insulin is responsible for maintaining glucose homeostasis by activating glycogen synthesis and inhibiting de novo glucose synthesis. Interruption or improper functioning of the insulin ... -
Characterisation and formulation of natural cyclodecapeptides with anti-Candida activity
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: The increase in the number of fungal infections since the 1980s is a major concern globally. Fungal infections affect various medical and agricultural sectors. A limited number of available antifungal ... -
The expression, purification and characterization of escherichia coli NudL, a putative coenzyme A hydrolase
(Stellenbosch : Stellenbosch University, 2021-04)ENGLISH ABSTRACT: Coenzyme A (CoA) is an essential cofactor that is synthesized by a conserved five-step pathway from pantothenic acid (vitamin B5). The regulation of CoA levels is vital in supporting normal cellular ... -
Investigating the influence of the progesterone receptor isoforms on androgen receptor activity in breast and prostate cancer cell lines
(Stellenbosch : Stellenbosch University, 2021-04)ENGLISH ABSTRACT: Breast cancer growth and survival are primarily dependent on signalling of estrogens via the estrogen receptor (ER), while for prostate cancer it is dependent on androgens acting via the androgen ... -
Mathematical modelling of glycolysis in cancer cell lines
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Most cancer cells exhibit an increase in glucose uptake and lactate produc- tion, a phenomenon known as the "Warburg effect" or aerobic glycolysis, and considered to be a hallmark of cancer ... -
Mathematical modelling of glycolysis in differentiated mouse adipocytes 3T3-L1
(Stellenbosch : Stellenbosch UniversityStellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Diabetes mellitus is a metabolic disease characterised by high blood sugar levels, primarily caused by insulin resistance and the resulting inability of the body to process glucose. Any tissue or cell ... -
Modelling the insulin signaling pathway and glucose transport induction in differentiated 3T3-L1 mouse adipocytes
(Stellenbosch : Stellenbosch University, 2021-04)ENGLISH ABSTRACT: Insulin is the principal controller of energy homeostasis in the human body. It lowers postprandial blood glucose and enforces a change in cellu- lar metabolism to maintain glucose ... -
A bioinformatics tool to detect physical gene clusters in functional genomics data
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Many studies have investigated the biological effects of the external environment on the genetic expression of a living cell. This particular study looks at gene clusters that are switched on at a series ... -
Genolve : a bioinformatics tool for the study of structure-driven genome evolution
(Stellenbosch : Stellenbosch University, 2021-04)ENGLISH SUMMARY : The process of structural genomic evolution, how one genome may have evolved into another via large-scale rearrangement events, has been a topic of study for the last few decades. Numerous genomic sorting ... -
Characterising the gut microbiome of ostrich chicks reared under intensive conditions
(Stellenbosch : Stellenbosch University, 2020-12)ENGLISH ABSTRACT: Every year the ostrich industry suffers severe losses from the high mortality rate of intensively farmed ostrich chicks during early post-hatch development. One of the major contributors to the high ... -
Effect of yeasts and oenological parameters on acetaldehyde production during alcoholic fermentation of South African grape musts
(Stellenbosch : Stellenbosch University, 2020-03)ENGLISH ABSTRACT: Acetaldehyde plays a role in the rate of fermentation and the quality of wine. High levels of acetaldehyde in fermenting juice may result in sluggish/stuck fermentations, and in wine, it may impart ...
