Masters Degrees (Biochemistry): Recent submissions
Now showing items 1-20 of 122
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Effect of yeasts and oenological parameters on acetaldehyde production during alcoholic fermentation of South African grape musts
(Stellenbosch : Stellenbosch University, 2020-03)ENGLISH ABSTRACT: Acetaldehyde plays a role in the rate of fermentation and the quality of wine. High levels of acetaldehyde in fermenting juice may result in sluggish/stuck fermentations, and in wine, it may impart ... -
An investigation into the effects of macromolecular crowding on the kinetics of upper glycolytic enzymes in Saccharomyces cerevisiae
(Stellenbosch : Stellenbosch University, 2020-03)ENGLISH ABSTRACT: In order for mathematical models of metabolism to accurately emulate experimental data the conditions in which parameter values are obtained must be close to the actual in vivo environment. However, this ... -
Whole-body modelling of glucose and lactate dynamics in plasmodium falciparum malaria
(Stellenbosch : Stellenbosch University, 2020-03)ENGLISH ABSTRACT: Malaria is the most important parasitic disease affecting man, and continues to threaten public health in developing countries where the disease is endemic. Within the genus Plasmodium, falciparum is ... -
Investigating the dynamics of hydrogen peroxide metabolism in the peroxiredoxin system of Saccharomyces cerevisiae
(Stellenbosch : Stellenbosch University, 2020-03)ENGLISH ABSTRACT: Reactive oxygen species (ROS) are derivations of molecular oxygen that can have detrimental e ects in cells. ROS can readily react with DNA, proteins and lipids often resulting in the loss of structure ... -
Investigation of the antifungal activity of tryptophan-rich cyclic peptides
(Stellenbosch : Stellenbosch University, 2019-01)ENGLISH ABSTRACT: The global population of immunocompromised individuals has been rising due to the immunosuppressive nature of advanced medical interventions such as chemotherapy for cancer and immunosuppressive conditions ... -
A comparative analysis of within-host models of malaria infection with immune response
(Stellenbosch : Stellenbosch University, 2019-04)ENGLISH ABSTRACT: With growing resistance of malaria parasites to different antimalarial treatments, there is an ever present need for new investigative approaches into disease eradication. The symptoms of the disease ... -
The effect of adenylate kinase on the glycolytic oscillations of Saccharomyces cerevisiae
(Stellenbosch : Stellenbosch University, 2019-02)ENGLISH ABSTRACT: The regulation of phosphofructokinase (PFK) by ATP and AMP is a necessary feature for glycolytic oscillations. The enzyme adenylate kinase (AK) is responsible for the interconversion of ATP + AMP 2 ... -
The role of PFK in the oscillatory yeast strain X2180
(Stellenbosch : Stellenbosch University, 2019-04)ENGLISH ABSTRACT: The elucidation of mechanisms involved in glycolytic oscillations in yeast can lead to a deeper understanding of the metabolic organisation in living systems. These oscillations, detected in the ... -
Combinatorial treatments of tamoxifen with SM6Met, a selective estrogen receptor subtype modulator (SERSM), from Cyclopia subternata are superior to current endocrine treatments in breast cancer cell models.
(Stellenbosch : Stellenbosch University, 2018-11)ENGLISH ABSTRACT: Globally and in South Africa breast cancer is the most frequent malignancy amongst women. Most breast cancers are estrogen receptor (ER) positive and requires estrogen for growth and metastasis. Adverse ... -
The in vitro inhibition of adrenal steroidogenic enzymes and modulation of adrenal hormone production by Sceletium tortuosum
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH ABSTRACT: This study describes: • The development and validation of an ultra-performance convergence chromatography tandem mass spectrometry (UPC2-MS/MS) analytical method for the separation, detection and ... -
Production and characterisation of analogues of the antimicrobial tyrocidine peptides with modified aromatic amino acid residues
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH ABSTRACT: With the approach of a post-antibiotic era in which the current arsenal of antibiotic compounds can no longer combat common bacterial infections, the search for novel compounds to fight against antimicrobial ... -
A systematic investigation into the quantitative effect of pH changes on the upper glycolytic enzymes of Escherichia coli and Saccharomyces cerevisiae
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH ABSTRACT: Kinetic modelling of biological phenomena in an attempt to understand the underlying dynamics and complexity of life is becoming an indispensable tool to systems biology. A new paradigm of mathematical ... -
Investigating the parts to understand the whole : contribution of phenolic compounds to the desired estrogenic activity of SM6Met fractions from Cyclopia subternata
(Stellenbosch :Stellenbosch University, 2018-03)ENGLISH ABSTRACT: Decreasing estrogen levels, associated with menopause, may cause several unpleasant symptoms. Hormone replacement therapy (HRT) relieves these symptoms, but increases the risk of developing breast ... -
Crosstalk between the androgen receptor and progesterone receptor isoforms in breast and prostate cancer
(Stellenbosch : Stellenbosch Univesity, 2018-03)ENGLISH ABSTRACT: Breast and prostate cancer growth and survival are dependent on signalling via the estrogen receptor (ER) and androgen receptor (AR), respectively. However, other steroid receptors such as the progesterone ... -
Bioinformatic characterisation of genes associated with coenzyme A biosynthesis in mycoplasmas and expression and isolation of dephospho-coenzyme A kinase from Mycoplasma sp. Ms02
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH ABSTRACT: The South African ostrich industry is internationally the leading provider of ostrich products. The increasing popularity of ostrich products has resulted in the adjustment of production strategies, ... -
Flux balance analysis of Plasmodium falciparum growth and energy metabolism
(Stellenbosch : Stellenbosch University, 2017-12)ENGLISH ABSTRACT: Genome-scale network reconstructions serve as an ideal tool for the modeling of large, complex metabolic networks. In this study we use ux-balance analysis to investigate key amino acid dependencies ... -
Biochemical and genetic characterization of bacteria isolated from diseased rainbow trout (Oncorhynchus mykiss) farmed in Lesotho and Mpumalanga province of South Africa
(Stellenbosch : Stellenbosch University, 2017-12)ENGLISH ABSTRACT: Rainbow trout farms in Mpumalanga Province, South Africa and Lesotho, have periodically suffered significant losses from infections caused by Gram-positive bacteria. Such outbreaks have hampered the ... -
An investigation into the potato leafroll virus problem in the Sandveld region, South Africa
(Stellenbosch : Stellenbosch University, 2017-12)ENGLISH ABSTRACT: Potato leafroll virus (PLRV) is responsible for significant yield losses in the South African (SA) potato industry. PLRV incidence in the Sandveld region has increased dramatically over the past 15 years. ... -
The effect of salsola tuberculatiformis bostchantzev on the androgen and glucocorticoid receptors in prostate cancer cell lines
(Stellenbosch : Stellenbosch University, 2017-12)ENGLISH ABSTRACT: This study describes: 1. The preparation of a biologically active methanol extract from S.tuberculatiformis. 2. The demonstration of biological activity for both the crude S.tuberculatiformis extract ... -
The ostrich mycoplasma Ms01 : the identification, isolation, and modification of the P100 vaccine candidate gene and immunity elicited by poultry mycoplasma vaccines
(Stellenbosch : Stellenbosch University, 2009-03)ENGLISH ABSTRACT: The South African ostrich industry is currently being threatened by respiratory disease in feedlot ostriches with dramatic production losses. Three ostrich-specific mycoplasmas, Ms01, Ms02 and Ms03 were ...
