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    Control analysis of adrenal Sseroidogenesis 

    Genade, Tyrone (Stellenbosch : University of Stellenbosch, 2004-12)
    This study describes: 1. Investigation of product inhibition regarding the metabolism of progesterone in ovine adrenal micosomes. 2. The employment of novel cell culture techniques to study the effect of CYP17 and ...
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    The inhibitory effect of rooibos on cytochromes P450 and downstream in vitro modulation of steroid hormones 

    Mugari, Mufaro Buhlebenkosi (Stellenbosch : Stellenbosch University, 2015-04)
    ENGLISH ABSTRACT: This study describes: 1. Substrate binding assays investigating the effects of methanolic extracts of unfermented and fermented Rooibos on the binding of natural substrates to ovine adrenal microsomal ...
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    An operational model for estrogenic action in the presence of sex hormone binding globulin (SHBG) 

    Vismer, Michael John (Stellenbosch : Stellenbosch University, 2007-03)
    ENGLISH ABSTRACT: The aim of this study was to build a mathematical model that describes the binding of 17- -estradiol (E2) to estrogen receptor (ER- ) and the influence the sex hormone binding globulin (SHBG) has on ...
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    The production and purification of functional steroid hormone receptor ligand binding domains towards the development of a biological endocrine disruptor detection system 

    Tait, Timo (Stellenbosch : Stellenbosch University, 2015-04)
    ENGLISH ABSTRACT: During the last two and a half decades a large body of research has accumulated indicating the presence of various natural and synthetic chemical compounds within the environment capable of inducing ...
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    Construction and analysis of a kinetic model of the ovine adrenal steroidogenic subsystem comprising of CYP17 and 3β-HSD 

    van Schalkwyk, Frederick Josephus (Erick) (Stellenbosch : Stellenbosch University, 2016-03)
    ENGLISH ABSTRACT : This study describes: how time-dependent experimental data, describing the reactions catalyzed by ovine cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17), was obtained using pregnenolone and ...

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    AuthorGenade, Tyrone (1)Mugari, Mufaro Buhlebenkosi (1)Tait, Timo (1)van Schalkwyk, Frederick Josephus (Erick) (1)Vismer, Michael John (1)Subject
    Steroid hormones (5)
    UCTD (3)Dissertations -- Biochemistry (2)Theses -- Biochemistry (2)Adrenocortical hormones (1)Adrenocortical hormones -- Models (1)Baculovirus expression vector system (1)Biosynthesis -- Models (1)Cytochrome P-450 (1)Endocrine disrupting chemicals (1)... View MoreDate Issued2010 - 2016 (3)2004 - 2009 (2)Has File(s)Yes (5)
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