Search
Now showing items 1-5 of 5
Control analysis of adrenal Sseroidogenesis
(Stellenbosch : University of Stellenbosch, 2004-12)
This study describes:
1. Investigation of product inhibition regarding the metabolism of progesterone in ovine
adrenal micosomes.
2. The employment of novel cell culture techniques to study the effect of CYP17 and ...
The inhibitory effect of rooibos on cytochromes P450 and downstream in vitro modulation of steroid hormones
(Stellenbosch : Stellenbosch University, 2015-04)
ENGLISH ABSTRACT: This study describes:
1. Substrate binding assays investigating the effects of methanolic extracts of
unfermented and fermented Rooibos on the binding of natural substrates to ovine
adrenal microsomal ...
An operational model for estrogenic action in the presence of sex hormone binding globulin (SHBG)
(Stellenbosch : Stellenbosch University, 2007-03)
ENGLISH ABSTRACT: The aim of this study was to build a mathematical model that describes the
binding of 17- -estradiol (E2) to estrogen receptor (ER- ) and the influence
the sex hormone binding globulin (SHBG) has on ...
The production and purification of functional steroid hormone receptor ligand binding domains towards the development of a biological endocrine disruptor detection system
(Stellenbosch : Stellenbosch University, 2015-04)
ENGLISH ABSTRACT: During the last two and a half decades a large body of research has accumulated indicating the presence of various natural and synthetic chemical compounds within the environment capable of inducing ...
Construction and analysis of a kinetic model of the ovine adrenal steroidogenic subsystem comprising of CYP17 and 3β-HSD
(Stellenbosch : Stellenbosch University, 2016-03)
ENGLISH ABSTRACT : This study describes: how time-dependent experimental data, describing the reactions catalyzed by ovine
cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17), was obtained using
pregnenolone and ...