Now showing items 1-5 of 5
Towards a kinetic model of the Entner-Doudoroff pathway in Zymomonas mobilis
(Stellenbosch : Stellenbosch University, 2014-12)
ENGLISH ABSTRACT: Metabolic networks of cellular systems are complex, in that there are numerous components with multiple non-linear interactions. To understand how these networks work they are often split into manageable ...
Comparison of progress curve analysis and initial rate kinetics for the estimation of identifiable enzyme kinetic parameters : a case study using two glycolytic enzymes from Sulfolobus solfataricus
(Stellenbosch : Stellenbosch University, 2016-12)
ENGLISH ABSTRACT: Obtaining accurate parameter value estimations is imperative to studying enzyme kinetics. It is also important that these parameter values be identifiable. The nonidentifiability of parameter estimations ...
A generic rate equation for catalysed, template-directed polymerisation and its use in computational systems biology
(Stellenbosch : Stellenbosch University, 2011-12)
ENGLISH ABSTRACT: Progress in computational systems biology depends crucially on the availability of generic rate equations that accurately describe the behaviour and regulation of catalysed processes over a wide range ...
An investigation into the effects of macromolecular crowding on the kinetics of upper glycolytic enzymes in Saccharomyces cerevisiae
(Stellenbosch : Stellenbosch University, 2020-03)
ENGLISH ABSTRACT: In order for mathematical models of metabolism to accurately emulate experimental data the conditions in which parameter values are obtained must be close to the actual in vivo environment. However, this ...
Mathematical modelling of glycolysis in cancer cell lines
(Stellenbosch : Stellenbosch University, 2021-03)
ENGLISH ABSTRACT: Most cancer cells exhibit an increase in glucose uptake and lactate produc- tion, a phenomenon known as the "Warburg effect" or aerobic glycolysis, and considered to be a hallmark of cancer ...