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Investigating the dynamics of hydrogen peroxide metabolism in the peroxiredoxin system of Saccharomyces cerevisiae
(Stellenbosch : Stellenbosch University, 2020-03)
ENGLISH ABSTRACT: Reactive oxygen species (ROS) are derivations of molecular oxygen that can have detrimental e ects in cells. ROS can readily react with DNA, proteins and lipids often resulting in the loss of structure ...
An investigation into the effects of macromolecular crowding on the kinetics of upper glycolytic enzymes in Saccharomyces cerevisiae
(Stellenbosch : Stellenbosch University, 2020-03)
ENGLISH ABSTRACT: In order for mathematical models of metabolism to accurately emulate experimental data the conditions in which parameter values are obtained must be close to the actual in vivo environment. However, this ...
A bioinformatics tool to detect physical gene clusters in functional genomics data
(Stellenbosch : Stellenbosch University, 2021-03)
ENGLISH ABSTRACT: Many studies have investigated the biological effects of the external environment on the genetic expression of a living cell. This particular study looks at gene clusters that are switched on at a series ...
Mathematical modelling of glycolysis in differentiated mouse adipocytes 3T3-L1
(Stellenbosch : Stellenbosch UniversityStellenbosch : Stellenbosch University, 2021-03)
ENGLISH ABSTRACT: Diabetes mellitus is a metabolic disease characterised by high blood sugar levels,
primarily caused by insulin resistance and the resulting inability of the
body to process glucose. Any tissue or cell ...
Mathematical modelling of glycolysis in cancer cell lines
(Stellenbosch : Stellenbosch University, 2021-03)
ENGLISH ABSTRACT: Most cancer cells exhibit an increase in glucose uptake and lactate produc- tion, a
phenomenon known as the "Warburg effect" or aerobic glycolysis, and considered to be a hallmark of
cancer ...
Quantification of the insulin response in rat L6 skeletal muscle cells
(Stellenbosch : Stellenbosch University, 2020-04)
ENGLISH ABSTRACT: Mathematical models can help us to understand complex molecular mechanisms underlying diseases. There is a lack of these types of models describing the cellular processes involved in conditions such as ...
Modelling the insulin signaling pathway and glucose transport induction in differentiated 3T3-L1 mouse adipocytes
(Stellenbosch : Stellenbosch University, 2021-04)
ENGLISH ABSTRACT: Insulin is the principal controller of energy homeostasis in the human
body. It lowers postprandial blood glucose and enforces a change in cellu- lar
metabolism to maintain glucose ...
Characterisation and formulation of natural cyclodecapeptides with anti-Candida activity
(Stellenbosch : Stellenbosch University, 2021-03)
ENGLISH ABSTRACT: The increase in the number of fungal infections since the 1980s is a major concern globally. Fungal infections affect various medical and agricultural sectors. A limited number of available antifungal ...
The effect of acute phase proteins on hepatic insulin signalling
(Stellenbosch : Stellenbosch University, 2020-03)
ENGLISH ABSTRACT: Insulin resistance is the main risk factor for the development of type-2 diabetes (T2D). It is
described as perturbed insulin signalling in the peripheral target tissues (which include the
liver, ...
Co-regulation of insulin signalling by glucocorticoids and pro-inflammatory cytokines
(Stellenbosch : Stellenbosch University, 2021-04)
ENGLISH ABSTRACT: In the liver, insulin is responsible for maintaining glucose homeostasis by activating glycogen synthesis and inhibiting de novo glucose synthesis. Interruption or improper functioning of the insulin ...