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The characterization of 17β-hydroxysteroid dehydrogenase type 2 (17βHSD2) activity towards novel C19 substrates.
(Stellenbosch : Stellenbosch University, 2017-03)
ENGLISH ABSTRACT: Castration resistant prostate cancer (CRPC) is an androgen dependent disease driven by the intratumoural metabolism of adrenal androgen precursors to potent androgens. The alternative 5α-dione pathway ...