Browsing Doctoral Degrees (Biochemistry) by Title
Now showing items 1-20 of 69
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Altered lipid metabolism as a possible mechanism in fumonisin-induced hepatocarcinogenesis in rats and investigations into risk assessment in humans
(Stellenbosch : Stellenbosch University, 2013-12)ENGLISH ABSTRACT: Exposure to food contaminates such as mycotoxins have been associated with a variety of animal and human diseases worldwide. In South Africa, maize is the most To further refine risk assessment in the ... -
Bioaffinity separation using ligand-modified pluronic and synthetic membranes
(Stellenbosch : University of Stellenbosch, 2011-10)ENGLISH ABSTRACT: A new membrane based affinity separation system that is bio-specific, biocompatible, well characterised and capable of being regenerated or re-used is described. The amphiphilic non-ionic surfactant ... -
A biochemical study of the effect of ultraviolet treatment on bovine milk and Cheddar cheese
(Stellenbosch : Stellenbosch University, 2015-12)ENGLISH ABSTRACT: This study describes: 1. The evaluation of a novel, patented thin-film, turbulent-flow Ultravioletdisinfection system as an alternative processing method to thermal pasteurisationfor the disinfection of ... -
The biochemical study of the R- and S-enantiomers of 2-(4-acetoxyphenyl)-2-chloro-Nmethylethylammonium chloride (Compound A).
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT: The study describes: . The synthesis of a racemic mixture of Compound A (2-(4-acetoxyphenyl)-2-chloro-N-methylethylammonium chloride), a synthetic analogue of the active compound isolated from the African ... -
A biochemical study of tissue type plasminogen activator in bovine milk
(Stellenbosch : Stellenbosch University, 2007-03)ENGLISH ABSTRACT: This study describes: 1. The isolation and the purification of tissue type plasminogen activator and urokinase plasminogen activator in bovine milk. 2. The biochemical characterisation of tissue type ... -
Biofilms as multifunctional surface coatings and adaptive systems: a biomimetic approach
(Stellenbosch : Stellenbosch University, 2016-12)ENGLISH ABSTRACT: Biomimicry is an emerging scientific discipline that promotes nature-inspired innovation for sustainable solutions. Several patterns and survival strategies are repeated in Nature and these have been ... -
Cancer modulating properties of unique South African herbal teas (rooibos and honeybush) in short term in vitro and in vivo carcinogenesis assays
(Stellenbosch : Stellenbosch University, 2004-12)ENGLISH ABSTRACT: This thesis provides the first scientific evidence on the cancer modulating properties of two unique South African herbal teas, rooibos (Aspalathus Iinearis) and honeybush (Cyclopia intermedia) utilizing ... -
Cape baboon Cytochrome P450 11β-hydroxylases : the characterization of two functional enzymes
(Stellenbosch : Stellenbosch University, 2007-03)ENGLISH ABSTRACT: This study: 1. Describes the localization of CYP11B1 in the Cape baboon adrenal gland using Western blot analysis. CYP11B1 was localized to the adrenal cortex and medulla. 2. Describes the catalytic ... -
Changes in cell surface and metabolism associated with strains of Listeria monocytogenes displaying different sensitivities to class IIa bacteriocins
(Stellenbosch : Stellenbosch University, 2003-12)ENGLISH ABSTRACT: The possible use of the bacterially produced antimicrobial peptides, and in particular class IIa bacteriocins as food preservatives is a motivating factor in studies on resistance to them by food-borne ... -
Characterisation of small cyclic peptides with antilisterial and antimalarial activity
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: Antimicrobial peptides (AMPs) are currently the most researched group of compounds for new antimicrobial drugs especially with the rise in resistance to almost all available drugs by public health ... -
Characteristics and adaptation of skeletal muscle to endurance exercise
(Stellenbosch : University of Stellenbosch, 2011-10)ENGLISH ABSTRACT: Skeletal muscle adapts to stimuli by modifying structural and metabolic protein expression. Furthermore, a muscle group may vary within itself to accommodate specialisation in regions. Structural and ... -
Characterization of prokaryotic pantothenate kinase enzymes and the development of type-specific inhibitors
(Stellenbosch : Stellenbosch University, 2011-12)ENGLISH ABSTRACT: Pantothenate kinase (PanK) enzymes catalyze the first reaction in the five step biosynthesis of the essential cofactor coenzyme A. Enzymes representing each of the three identified PanK types have been ... -
Chemopreventive properties of South African herbal teas, rooibos (Aspalathus linearis) and honeybush (Cyclopia spp) : mechanisms against skin carcinogenesis
(Stellenbosch : Stellenbosch University, 2013-12)ENGLISH ABSTRACT: The present study employed a two-phased approach to investigate the possible mechanisms involved in the chemopreventive properties of rooibos (Aspalathus linearis) and different honeybush species (Cyclopia ... -
Cloning and identification of genes involved in the interaction between the bacterial stone fruit pathogen Pseudomonas syringae pv. syringae strain NV and plum trees
(Stellenbosch : Stellenbosch University, 2001-03)ENGLISH ABSTRACT: Bacterial canker of stone fruit, caused by Pseudomonas syringae pv. syringae, is one of the most destructive crop diseases in South Africa. Chemical control has failed completely and effective long-term ... -
Coenzyme A biosynthesis and Coenzyme A-dependent redox processes as targets for anti-staphylococcal drug development
(Stellenbosch : Stellenbosch University, 2015-12)ENGLISH SUMMARY: Staphylococcus aureus, the bacterium that causes most hospital-acquired in humans is rapidly becoming more prevalent in the community and, alarmingly, increasingly resistant to the current arsenal of ... -
Coenzyme a biosynthesis and utilization in Plasmodium falciparum : drug targets for antimalarial chemotherapy
(Stellenbosch : Stellenbosch University, 2014-12)ENGLISH ABSTRACT: Pantothenate (also known as Vitamin B5) is the sole precursor of the essential enzyme cofactor coenzyme A (CoA) that is required in several metabolic reactions virtually in all living organisms including ... -
A comparative analysis of CoA biosynthesis in selected organisms: a metabolite study
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH SUMMARY: This study investigated the biochemical regulation of CoA production because it is an essential pathway that presents an important target for antimicrobial drug discovery studies. Currently, the specific ... -
A comparative analysis of the G1/S transition control in kinetic models of the eukaryotic cell cycle
(Stellenbosch : University of Stellenbosch, 2009-12)ENGLISH ABSTRACT: The multiplication of cells proceeds through consecutive phases of growth and division (G1, S, G2 and M phases), in a process known as the cell cycle. The transition between these phases is regulated ... -
Comparative cross-species analysis of detailed kinetic models of glycolysis
(Stellenbosch : University of Stellenbosch, 2009-12)ENGLISH ABSTRACT: With the recent advances in the field of molecular biology, there is an increased need to integrate data on the various constituents of the cell in kinetic models that can predict and describe cellular ... -
Comparative study of the molecular mechanism of action of the synthetic progestins, Medroxyprogesterone acetate and Norethisterone acetate
(Stellenbosch : University of Stellenbosch, 2010-03)ENGLISH ABSTRACT: Medroxyprogesterone acetate (MPA) and norethisterone (NET) and its derivatives (norethisterone enanthate (NET-EN); norethisterone acetate (NETA)), are used by millions of women as contraceptives and in ...
