Browsing Doctoral Degrees (Physiological Sciences) by Title
Now showing items 1-20 of 31
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Anthracycline-induced cardiotoxicity : the role of proteolytic pathways
(Stellenbosch : Stellenbosch University, 2012-03)ENGLISH ABSTRACT: Introduction: The anthracyclines (ACs), daunorubicin (DNR) and doxorubicin (DXR) are two of the most effective drugs known for the treatment of systemic neoplasms and solid tumours. However, their ... -
Assessment of Metabolic Therapy for Acute Heart Failure
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT: Introduction Acute heart failure (AHF) is the most common primary diagnosis for hospitalized heart disease cases in Africa. Increased fatty acid oxidation (FAO) with heart failure (HF) triggers detrimental ... -
The association between genotype and BMI, health and lifestyle indicators as well as weight loss outcomes in overweight/obese Caucasian adults
(Stellenbosch : University of Stellenbosch, 2011-03)ENGLISH ABSTRACT: Genetic screening to improve obesity treatment outcomes is available despite the lack of conclusive evidence, specifically for Caucasian South Africans, in this regard. The aim of this study was to ... -
Cell death in hyppxic injury : signaling mechanisms and dynamics in the decision making process
(Stellenbosch : University of Stellenbosch, 2009-12)ENGLISH ABSTRACT: Three main morphologies of cell death have been described in the diseased myocardium, type I, better known as apoptotic cell death, which is characterized by cell shrinkage and chromatin condensation, ... -
Chemoresistance in a breast cancer animal model: the role of obesity and inflammation
(Stellenbosch : Stellenbosch University, 2019-12)ENGLISH ABSTRACT: Background: Globally an increase in obesity incidence represent a major health concern amongst a rising incidence of impaired treatment outcomes of breast cancer patients. Adipose tissue and/or adipocytes, ... -
The contribution of inflammatory mediators to delayed secondary muscle damage
(Stellenbosch : Stellenbosch University, 2013-03)ENGLISH ABSTRACT: Background: Understanding the contribution of divergent individual response patterns remains a key objective in identifying mechanisms of inflammation and potential factors limiting the resolution of ... -
Correlations between stress-associated anxiety and physiological determinants of health in adolescents
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: Anxiety disorders are among the most prevalent of psychiatric disorders across age groups, with onset typically in childhood or early adolescence, and risk for developing an anxiety disorder increasing ... -
Dietary red palm oil-supplementation offers cardioprotection against Ischaemia/Reperfusion injury : possible cellular mechanisms involved
(Stellenbosch : University of Stellenbosch, 2005-12)ENGLISH ABSTRACT: Activation of the NO-cGMP pathway is associated with myocardial protection against ischaemia/reperfusion injury. However, high-cholesterol diets alter function of this pathway and these alterations have ... -
Differential effects of TNfα on satellite cell differentiation
(Stellenbosch : Stellenbosch University, 2007-03)ENGLISH ABSTRACT: Tumour necrosis factor alpha (TNFα) is a pleiotropic cytokine and has a wide variety of dose dependent cellular effects ranging from cell growth and differentiation, to inducing apoptosis. It has long ... -
Differential tolerance of a cancer and a non-cancer cell line to amino acid deprivation : mechanistic insight and clinical potential
(Stellenbosch : Stellenbosch University, 2012-03)ENGLISH ABSTRACT: Introduction – Due to spatial separation from the native vascular bed, solid tumours develop regions with limited access to nutrients essential for growth and survival. The promotion of a process known ... -
The effect of melatonin treatment on doxorubicin-induced skeletal muscle atrophy within a cancer model
(Stellenbosch : Stellenbosch University, 2018-12)ENGLISH ABSTRACT: Background and Aim: Skeletal muscle atrophy is a major concern in patients suffering with malignancy. Chemotherapeutic agents, such as doxorubicin (DOX), can further exacerbate this loss of skeletal ... -
The effect of the TGF-β isoforms on progenitor cell recruitment and differentiation into cardiac and skeletal muscle
(Stellenbosch : University of Stellenbosch, 2007-12)Definition: Stem cells are unspecialised cells with the capacity for long-term self-renewal and the ability to differentiate into multiple cell-lineages. The potential for the application of stem cells in clinical settings ... -
The effects of nutrient deprivation on macroautophagic flux and chaperone-mediated autophagy in a model of alzheimer's disease
(Stellenbosch : Stellenbosch University, 2018-12)ENGLISH ABSTRACT: Introduction: Alzheimer’s disease (AD) is a devastating neurodegenerative disease characterized by progressive cognitive impairment, particularly in brain regions crucial for learning and memory. These ... -
An evaluation of the hepatic proteomic signature in identifying cancer tolerance and resistance mechanisms in a mouse allograft system
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT: Background The unfavourable therapeutic index of most treatment modalities has greatly impeded progress in the development of effective cancer therapy. Therefore a need exists for treatment modalities ... -
Exercise, stress and immune system functional responses
(Stellenbosch : University of Stellenbosch, 2004-12)ENGLISH ABSTRACT: Stress related to chronic exercise affects both the immune and endocrine systems, but there are still many issues that are poorly understood, particularly effects of stress on the functional capacity ... -
Faktore wat die prestasie en gesondheid van vroue-atlete kan beinvloed
(Stellenbosch : Stellenbosch University, 2003-12)ENGLISH ABSTRACT: Although it is common knowledge that regular exercise has many beneficial effects on the human body, it is also true that many highly competitive athletes neglect their health for the sake of performance. ... -
The hexosamine biosynthetic pathway induces gene promoter activity of the cardiac-enriched isoform of acetyl-CoA carboxylase
(Stellenbosch : Stellenbosch University, 2013-03)ENGLISH ABSTRACT: The cardiac isoform of acetyl-CoA carboxylase (ACCβ) produces malonyl-CoA, a potent inhibitor of mitochondrial fatty acid (FA) uptake; thus increased ACCβ activity decreases fatty acid utilization thereby ... -
Hyperglycemia-induced activation of the hexosamine biosynthetic pathway causes myocardial cell death
(Stellenbosch : University of Stellenbosch, 2009-12)ENGLISH ABSTRACT: OBJECTIVE – Oxidative stress increases flux through the hexosamine biosynthetic pathway (HBP) resulting in greater O-GlcNAcylation of target proteins. Since increased oxidative stress and HBP flux are ... -
Hyperglycemia-mediated onset of myocardial insulin resistance – unraveling molecular mechanisms and identifying therapeutic targets
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: Background - Although acute hyperglycemic episodes are linked to lower glucose uptake, underlying mechanisms driving this process remain unclear. We hypothesized that acute hyperglycemia triggers reactive ... -
Immune activation in HIV-positive patients on combined anti-retroviral treatment (cART) as a high risk group for the development of cardiovascular diseases
(Stellenbosch : Stellenbosch University, 2017-12)ENGLISH ABSTRACT: Although roll-out of combined anti-retroviral treatment (cART) has blunted HIV-AIDS onset, studies show increased development of cardio-metabolic complications in HIV-infected individuals. For this study ...
