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Hyperglycemia-induced activation of the hexosamine biosynthetic pathway causes myocardial cell death

Rajamani, Uthra (Stellenbosch : University of Stellenbosch, 2009-12)

ENGLISH ABSTRACT: OBJECTIVE – Oxidative stress increases flux through the hexosamine biosynthetic pathway (HBP) resulting in greater O-GlcNAcylation of target proteins. Since increased oxidative stress and HBP flux are ...
Cell death in hyppxic injury : signaling mechanisms and dynamics in the decision making process

Loos, Benjamin (Stellenbosch : University of Stellenbosch, 2009-12)

ENGLISH ABSTRACT: Three main morphologies of cell death have been described in the diseased myocardium, type I, better known as apoptotic cell death, which is characterized by cell shrinkage and chromatin condensation, ...