Now showing items 1-3 of 3
Increased flux through the hexosamine biosynthetic pathway leads to the induction of acetol-CoA caboxylase gene expression in the heart
(Stellenbosch : Stellenbosch University, 2008-03)
ENGLISH ABSTRACT: Gene expression of the cardiac isoform of acetyl-CoA carboxylase (ACCb) is induced in a glucose-dependent manner. ACCb produces malonyl-CoA, a potent inhibitor of mitochondrial fatty acid uptake. Previous ...
Exploring underlying mechanisms driving the onset of stress-induced insulin resistance
(Stellenbosch : Stellenbosch University, 2012-03)
ENGLISH ABSTRACT: Physical and psychological stressors trigger activation of the hypothalamo-pituitary-adrenocortical (HPA) axis that leads to enhanced secretion of glucocorticoids e.g. cortisol. Moreover, chronic ...
Increased hexosamine biosynthetic pathway flux impairs myocardial GLUT4 translocation
(Stellenbosch : University of Stellenbosch, 2009-03)
Aims and Background: According to the World Health Organization type 2 diabetes will constitute a major global burden of disease within the next few decades. In agreement, reports show that rapid urbanization and lifestyle ...