Browsing Masters Degrees (Physiological Sciences) by Title
Now showing items 1-20 of 83
-
Acute simulated hypoxia and ischemia in cultured C2C12 myotubes : decreased phosphatidylinositol 3-kinase (PI3K)/Akt activity and its consequences for cell survival
(Stellenbosch : Stellenbosch University, 2008-12)Cells are equipped with an array of adaptive mechanisms to contest the undesirable effects of ischemia and the associated hypoxia. Indeed, many studies have suggested that there is an increase in the PI3K/Akt pathway ... -
Ageing-associated oxidative stress and inflammation are alleviated by products from grapes
(Hindawi, 2016)Advanced age is associated with increased incidence of a variety of chronic disease states which share oxidative stress and inflammation as causative role players. Furthermore, data point to a role for both cumulative ... -
An alternative approach to premature luteal regression
(Stellenbosch : Stellenbosch University, 2006-12)ENGLISH ABSTRACT: Premature luteal regression occurs on average in 30% of superovulated sheep ewes. This phenomenon occurs early in the cycle before the embryo’s can be collected and is a major contributor to failure in ... -
Anthropometric characteristics and changes with HIV and ART in a randomly selected population in the Drakenstein region Western Cape Province
(Stellenbosch : Stellenbosch University, 2014-12)ENGLISH ABSTRACT: Background - Highly active antiretroviral therapy (HAART) has extended life expectancy and enhanced the well-being of HIVpositive individuals. Since there are concerns regarding HAART-mediated onset of ... -
Antioxidant (Oxiprovin TM) supplementation and muscle recovery from contusion injury - an in vivo study
(Stellenbosch : Stellenbosch University, 2007-12)ENGLISH ABSTRACT: Human studies on the response of muscle to contusion injury are limited, probably due to the large variability in injury severity and the non-specificity of clinical symptoms reported. To circumvent ... -
Are early proteomic and metabolic changes induced by long-term sugar-sweetened beverage consumption the key to unlocking the cardio-metabolic pandemic?
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT: INTRODUCTION: Cardio-metabolic diseases (e.g. type 2 diabetes mellitus) are a major cause of mortality worldwide. The incidence of cardio-metabolic diseases continues to increase, especially in low and ... -
ART-related body composition changes in adult women in a semi-rural South African context
(Stellenbosch : Stellenbosch University, 2006-12)ENGLISH ABSTRACT: The aim of this study was to investigate practical methods of monitoring AIDS related wasting and lipodystrophy in a resource-poor clinical setting with HIV infected women as the population group of ... -
Association between antioxidant status and MnSOD Ala-9Val polymorphism in trained male athletes (rugby players) and sedentary male students controlled for antioxidant intake
(Stellenbosch : Stellenbosch University, 2007-03)ENGLISH ABSTRACT: The human body has developed an integrated antioxidant defence system to protect against free radical damage. Acute exercise may result in the increased generation of free radicals, including reactive ... -
Association between cancer, adipose tissue and selected systemic markers : a possible classification according to body shape
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: Background: The metabolic syndrome (MetS) is a cluster of risk factors associated with an increased risk of developing chronic diseases of lifestyle, and has more recently been associated with cancer risk. ... -
The association between the metabolic syndrome and bone mineral density in pre- and post-menopausal farm workers
(Stellenbosch : Stellenbosch University, 2016-12)ENGLISH ABSTRACT: Introduction and aims: The prevalence of the metabolic syndrome (MetS) is increasing, both globally and in South Africa. Albeit so, limited data have been published in the South African context. One of ... -
Association between the metabolic syndrome and cancer risk : the potential role of fatty acids on body composition
(Stellenbosch : Stellenbosch University, 2016-12)ENGLISH ABSTRACT: Background: Sub-Sahara Africa is experiencing an epidemiological transition with an increasing burden of non-communicable diseases (NCDs) including obesity, hypertension, insulin resistance (IR) and ... -
Can the Sutherlandia herb or resistance exercise reverse the stress inducing effects of a mild-intermittent stress procedure
(Stellenbosch : University of Stellenbosch, 2006-03)This study aimed to assess the effect of mild psychological stress in male Wistar rats using incremental, intermittent stress on parameters of atrophy, including body mass, soleus and extensor digitorum longus (EDL) muscle ... -
Cardio-metabolic effects of anti-retroviral treatment in the Cape Winelands region of South Africa
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: Background: Although highly active antiretroviral therapy (HAART) has significantly improved the survival of human immunodeficiency virus (HIV)-infected patients there are increased concerns regarding the ... -
Changes in acetylcholine receptor expression : neuromuscular junction morphology and associated myonuclei in BALB/C mice following muscle contusion injury
(Stellenbosch : Stellenbosch University, 2015-03)ENGLISH ABSTRACT: Contusion injuries cause significant muscle damage, that effects skeletal muscle in its entirety, including the innervating motorneuron and the myofibre’s neuromuscular junction (NMJ). Upon injury, the ... -
Circadian rhythms as novel chemotherapeutic strategies for breast cancer
(Stellenbosch : Stellenbosch University, 2014-12)ENGLISH ABSTRACT: Introduction: Mammalian circadian rhythms form an integral physiological system allowing for the synchronisation of all metabolic processes to daily light/dark cycles, thereby optimising their efficacy. ... -
A comparison of the effect of curcumin treatment on apoptosis, necrosis and autophagy in a MCF-7 mammary adenocarcinoma and a MCF-12A healthy mammary epithelial cell line
(Stellenbosch : University of Stellenbosch, 2009-03)Breast cancer is currently the primary cause of cancer-related death in women worldwide. Conventional treatments such as radiation and chemotherapy have many deleterious and long lasting side-effects, some of which are ... -
Cytokine super-families affect adult stem cells : IL-6 and the skeletal muscle niche
(Stellenbosch : University of Stellenbosch, 2011-03)ENGLISH ABSTRACT: Background: IL-6 belongs to a cytokine super-family known to affect cell proliferation, although other family members are better characterized. Proliferation promoting factors (IL-6) compete with ... -
Deubiquitination : does the answer to cardiotoxicity lie within the ubiquitin proteasome pathway
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT: Introduction: Cardiotoxicity, a complication that arises from anthracycline use is one that has confounded scientists for decades. Attempts have been made to attenuate the development of this condition ... -
Development of a transendothelial shuttle by macrophage modification
(Stellenbosch : Stellenbosch University, 2016-12)ENGLISH ABSTRACT: Background: Targeted stem cell delivery via macrophage modification is a novel and relatively non-invasive therapeutic intervention. Monocytes circulate through the vasculature and infiltrate damaged ... -
Does cardioprotection by autophagy go beyond acute cardiotoxicity?
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: Introduction and Aim The discovery of Doxorubicin (DOX) in the 1960s has drastically improved the survival rates of cancer patients; however, its success is limited by dose-dependent cardiotoxicity. While ...
