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A descriptive study to determine the prevalence of TPMT polymorphism in Healthy male subjects in Central South Africa (Stellenbosch : Stellenbosch University, 2014-03)ENGLISH SUMMARY : Thiopurine medications e.g. Azathioprine and 6-Mercaptopurine are metabolized by the thiopurine methyltransferase (TPMT) enzyme. This enzyme activity is highly variable due to polymorphism of the TPMT ...