Browsing Masters Degrees (Clinical Pharmacology) by Title
Now showing items 1-20 of 28
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Accuracy Optimization of anti-TB Drug Assays using Protein Evaluation in Calibration Curves during Pharmacokinetics Quality Assurance
(Stellenbosch : Stellenbosch University, 2021-12)ENGLISH ABSTRACT: Quality assurance of drug assaying is an important aspect in clinical testing. Accuracy is important to ensure correct bio-analytical results by constructing calibration curves that took blood ... -
Acute poisonings : a comparative study of hospital admissions versus poison centre consultations
(Stellenbosch : Stellenbosch University, 2001-12)ENGLISH ABSTRACT: A prospective study was conducted in 1999 to establish the incidence and nature of acute poisonings in the Cape Town / Western Cape region. This study was based on an analysis of Poison Centre queries ... -
Adverse drug reactions in paediatric in-patients in a South African tertiary hospital
(Stellenbosch : Stellenbosch University, 2017-12)ENGLISH SUMMARY: Purpose: Paediatric patients have more adverse drug reaction (ADR) rates than adults due to off-label use of medicines and the prevalence data of ADRs in Sub-Saharan African children is limited. The aim ... -
An analytical investigation of the impact of crushing of first-line antituberculosis medication and administration via a nasogastric tube
(Stellenbosch : Stellenbosch University, 2022-11)ENGLISH ABSTRACT: Background Currently, the treatment of TB patients admitted to an intensive care unit (ICU) in South African Hospitals is performed by the off-label practice of crushing the first-line antituberculosis ... -
Antimycobacterial agents : a study of Liposomal-Encapsulation, comparitive permeability of bronchial tissue and in vitro activity against mycobacterium tuberculosis isolates
(Stellenbosch : Stellenbosch University, 2012-12)ENGLISH ABSTRACT: In this thesis, research results are reported on the role of dipalmitoyl phosphatidyl choline (DPPC) and DPPC-liposomes on the in vitro permeability characteristics of various antimycobacterial drugs ... -
Biophysical properties of experimental compositions of a synthetic pulmonary surfactant synsurf® for aerosolisation
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH ABSTRACT: Synthetic pulmonary surfactant consists of phospholipid mixtures, free fatty acids and/or sterols, as well as specific protein constructs that mimic the functions of surfactant associated proteins B and/or ... -
A cross-sectional study to investigate the knowledge, attitudes, and current practices of pharmacovigilance, among medical doctors and pharmacists in South Africa
(Stellenbosch : Stellenbosch University, 2021-12)Background: Pharmacovigilance pertains to activities aimed at monitoring medicines for related safety concerns, thereby ensuring patient safety and wellbeing. The primary method of pharmacovigilance is spontaneous reporting ... -
A descriptive study to determine the prevalence of TPMT polymorphism in Healthy male subjects in Central South Africa
(Stellenbosch : Stellenbosch University, 2014-03)ENGLISH SUMMARY : Thiopurine medications e.g. Azathioprine and 6-Mercaptopurine are metabolized by the thiopurine methyltransferase (TPMT) enzyme. This enzyme activity is highly variable due to polymorphism of the TPMT ... -
Development of a LC-MS/MS method for the detection of snake venom toxins in human plasma
(Stellenbosch : Stellenbosch University, 2022-12)ENGLISH ABSTRACT: Background: Snakebite envenomation in sub-Saharan Africa significantly threatens human health. Species that was responsible for the envenomation are rarely positively identified. There are no rapid ... -
Development of LC-MS/MS toxicology screening methods for common poisoning agents in South Africa
(Stellenbosch : Stellenbosch University, 2020-12)ENGLISH ABSTRACT: Background: Hospitals admit many patients suffering from acute poisoning on a regular basis. Over a single year period the Tygerberg Poison Information Centre (TPIC) dealt with 4 771 consultations related ... -
Drug-drug interactions between antiretrovirals and fluconazole in HIV-infected patients
(Stellenbosch : Stellenbosch University, 2012-03)ENGLISH ABSTRACT: Background: HIV-positive patients have a significantly weakened immune system which makes them highly susceptible for opportunistic infections, requiring additional treatment. Cryptococcal meningitis ... -
The effect of dolutegravir on adipose tissue health
(Stellenbosch : Stellenbosch University, 2022-10)ENGLISH ABSTRACT: Introduction: Dolutegravir, an integrase strand transfer inhibitor (INSTI), forms part of the first-line antiretroviral (ARV) therapy. Despite low cost, fewer drug-drug interactions and minimal reported ... -
The effect of Dolutegravir on redox and vascular integrity
(Stellenbosch : Stellenbosch University, 2022-10)ENGLISH ABSTRACT: Background: Of the estimated 7.2 million people living with HIV (PLWH) in South Africa, more than 50% are on antiretroviral (ARV) medication. Dolutegravir (DTG), an integrase strand transfer inhibitor ... -
Effect of ultrasound on transdermal permeation of diclofenac and the temperature effects on human skin
(Stellenbosch : University of Stellenbosch, 2005-12)During the last two decades the effects of ultrasound on the transdermal diffusion of a wide variety of drugs have been extensively investigated. Because there is much uncertainty regarding the efficacy of and mechanisms ... -
Exploring and identifying the indigenous healers of madwaleni and their relationship with ethnobotany and healthcare
(Stellenbosch : Stellenbosch University, 2019-04)Rationale: The use of indigenous medicine is widely known in South Africa. In fact, it is estimated that 80-85% of black South Africans consult with indigenous healers in both rural and urban communities (Moshabela, et ... -
Inhibitory effect of selected herbal supplements on CYP450-mediated metabolism : an in vitro approach
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: INTRODUCTION Herbal products are popularly used as complementary and alternative medicines to treat a variety of conditions. Often patients use them in conjunction with conventional medicines. Herbal ... -
Karakterisering van die katalase van BCG : invloed van isoniasied op die gesuiwerde ensiem
(Stellenbosch : Stellenbosch University, 1990-12)ENGLISH ABSTRACT: Catalase was extracted and isolated from BCG bacilli by the following precedures : sonication, treatment with deoxyribonuclease, treatment with octyl glucoside and sonification, ammonium sulphate ... -
LC-MS/MS methods for the quantification of sulfasalazine and sulfapyridine in various matrices: application to a pharmacokinetic study
(Stellenbosch : Stellenbosch University, 2022-11)ENGLISH ABSTRACT: Introduction: An early phase clinical trial which took place at The Mercy Hospital for Women in Australia assessed the use of sulfasalazine as a treatment for preterm pre-eclampsia. This project consisted ... -
Neurological risk of prolonged low dose exposure to imidacloprid in zebrafish
(Stellenbosch : Stellenbosch University, 2022-11)ENGLISH ABSTRACT: Imidacloprid (IMI) is a systemic neonicotinoid insecticide intended to replace the organophosphate pesticides in agriculture. Extensive use of these pesticides increases the risk to the environment and ... -
Pharmacokinetic study of anti-tb drug para-aminosalicylic acid and its metabolites: a possible relationship with the development of toxicity
(Stellenbosch : Stellenbosch University, 2019-04)Background Para-aminosalicylic acid (PAS) is a bacteriostatic anti-tuberculosis (anti-TB) drug, used in the treatment of multi-drug resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB). While PAS has ...
