Browsing Masters Degrees (Clinical Pharmacology) by Title
Now showing items 1-20 of 21
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Accuracy Optimization of anti-TB Drug Assays using Protein Evaluation in Calibration Curves during Pharmacokinetics Quality Assurance
(Stellenbosch : Stellenbosch University, 2021-12)ENGLISH ABSTRACT: Quality assurance of drug assaying is an important aspect in clinical testing. Accuracy is important to ensure correct bio-analytical results by constructing calibration curves that took blood ... -
Acute poisonings : a comparative study of hospital admissions versus poison centre consultations
(Stellenbosch : Stellenbosch University, 2001-12)ENGLISH ABSTRACT: A prospective study was conducted in 1999 to establish the incidence and nature of acute poisonings in the Cape Town / Western Cape region. This study was based on an analysis of Poison Centre queries ... -
Adverse drug reactions in paediatric in-patients in a South African tertiary hospital
(Stellenbosch : Stellenbosch University, 2017-12)ENGLISH SUMMARY: Purpose: Paediatric patients have more adverse drug reaction (ADR) rates than adults due to off-label use of medicines and the prevalence data of ADRs in Sub-Saharan African children is limited. The aim ... -
Antimycobacterial agents : a study of Liposomal-Encapsulation, comparitive permeability of bronchial tissue and in vitro activity against mycobacterium tuberculosis isolates
(Stellenbosch : Stellenbosch University, 2012-12)ENGLISH ABSTRACT: In this thesis, research results are reported on the role of dipalmitoyl phosphatidyl choline (DPPC) and DPPC-liposomes on the in vitro permeability characteristics of various antimycobacterial drugs ... -
Biophysical properties of experimental compositions of a synthetic pulmonary surfactant synsurf® for aerosolisation
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH ABSTRACT: Synthetic pulmonary surfactant consists of phospholipid mixtures, free fatty acids and/or sterols, as well as specific protein constructs that mimic the functions of surfactant associated proteins B and/or ... -
A cross-sectional study to investigate the knowledge, attitudes, and current practices of pharmacovigilance, among medical doctors and pharmacists in South Africa
(Stellenbosch : Stellenbosch University, 2021-12)Background: Pharmacovigilance pertains to activities aimed at monitoring medicines for related safety concerns, thereby ensuring patient safety and wellbeing. The primary method of pharmacovigilance is spontaneous reporting ... -
A descriptive study to determine the prevalence of TPMT polymorphism in Healthy male subjects in Central South Africa
(Stellenbosch : Stellenbosch University, 2014-03)ENGLISH SUMMARY : Thiopurine medications e.g. Azathioprine and 6-Mercaptopurine are metabolized by the thiopurine methyltransferase (TPMT) enzyme. This enzyme activity is highly variable due to polymorphism of the TPMT ... -
Development of LC-MS/MS toxicology screening methods for common poisoning agents in South Africa
(Stellenbosch : Stellenbosch University, 2020-12)ENGLISH ABSTRACT: Background: Hospitals admit many patients suffering from acute poisoning on a regular basis. Over a single year period the Tygerberg Poison Information Centre (TPIC) dealt with 4 771 consultations related ... -
Drug-drug interactions between antiretrovirals and fluconazole in HIV-infected patients
(Stellenbosch : Stellenbosch University, 2012-03)ENGLISH ABSTRACT: Background: HIV-positive patients have a significantly weakened immune system which makes them highly susceptible for opportunistic infections, requiring additional treatment. Cryptococcal meningitis ... -
Effect of ultrasound on transdermal permeation of diclofenac and the temperature effects on human skin
(Stellenbosch : University of Stellenbosch, 2005-12)During the last two decades the effects of ultrasound on the transdermal diffusion of a wide variety of drugs have been extensively investigated. Because there is much uncertainty regarding the efficacy of and mechanisms ... -
Exploring and identifying the indigenous healers of madwaleni and their relationship with ethnobotany and healthcare
(Stellenbosch : Stellenbosch University, 2019-04)Rationale: The use of indigenous medicine is widely known in South Africa. In fact, it is estimated that 80-85% of black South Africans consult with indigenous healers in both rural and urban communities (Moshabela, et ... -
Inhibitory effect of selected herbal supplements on CYP450-mediated metabolism : an in vitro approach
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: INTRODUCTION Herbal products are popularly used as complementary and alternative medicines to treat a variety of conditions. Often patients use them in conjunction with conventional medicines. Herbal ... -
Karakterisering van die katalase van BCG : invloed van isoniasied op die gesuiwerde ensiem
(Stellenbosch : Stellenbosch University, 1990-12)ENGLISH ABSTRACT: Catalase was extracted and isolated from BCG bacilli by the following precedures : sonication, treatment with deoxyribonuclease, treatment with octyl glucoside and sonification, ammonium sulphate ... -
Pharmacokinetic study of anti-tb drug para-aminosalicylic acid and its metabolites: a possible relationship with the development of toxicity
(Stellenbosch : Stellenbosch University, 2019-04)Background Para-aminosalicylic acid (PAS) is a bacteriostatic anti-tuberculosis (anti-TB) drug, used in the treatment of multi-drug resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB). While PAS has ... -
Pharmacokinetics and dosing rationale of Para-Aminosalicylic acid in children and the evaluation of the in vitro metabolism of Ethionamide, Terizidone and Para-aminosalicylic acid
(Stellenbosch : Stellenbosch University, 2012-03)ENGLISH ABSTRACT: BACKGROUND: The emergence of mycobacterium tuberculosis resistance to first line drugs has renewed interest in second-line anti-tuberculosis drugs. Generally, Paraaminosalicylic acid (PAS) is less ... -
Pharmacokinetics of twice-daily versus once-daily dosing with granular slow-release para-aminosalicylic acid in adults on second-line anti-tuberculosis and antiretroviral treatment
(Stellenbosch : Stellenbosch University, 2013-12)ENGLISH ABSTRACT: Background: Para-aminosalicylic acid (PAS) is one of the first effective anti-tuberculosis agents and has become one of the principal second-line drugs to treat patients with an extended resistance spectrum. ... -
The role of Phosphodiesterase (PDE3) in heart protection.
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: Introduction: During a heart attack the blood supply to the heart is reduced significantly, known as ischemia (Reimer & Jennings, 1991). Energy generating pathways that require oxygen become inhibited in ... -
The role of surfactant in, and a comparison of, the permeability of porcine and human epithelia to various chemical compounds
(Stellenbosch : University of Stellenbosch, 2005-12)In this thesis, research results are reported on the role of natural and synthetic surfactants on the in vitro permeability characteristics of various chemical compounds across porcine (buccal, bronchial, arterial, venous ... -
The specific binding of the thyroid hormones to matrix isolated from rat liver nuclei
(Health & Medical Publishing Group, 1982)Specific binding sites for the thyroid hormones have been demonstrated in the liver nuclear matrix, a structural framework of the nucleus. When labelled 3,5,3'-tri-iodo-L-thyronine ([125I]T3) is injected into rats, 5% of ... -
Using STORM and TIRF in tandem to investigate adherence and migration patterns in stem cells
(Stellenbosch : Stellenbosch University, 2021-03)Background: Cell migration is a dynamic process in physiology requiring pseudopodia, elongated cell protrusions, to associate with the extracellular matrix (ECM) and propel cells forward. The interaction is established ...
