Browsing Masters Degrees (Clinical Pharmacology) by Title
Now showing items 16-28 of 28
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Inhibitory effect of selected herbal supplements on CYP450-mediated metabolism : an in vitro approach
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: INTRODUCTION Herbal products are popularly used as complementary and alternative medicines to treat a variety of conditions. Often patients use them in conjunction with conventional medicines. Herbal ... -
Karakterisering van die katalase van BCG : invloed van isoniasied op die gesuiwerde ensiem
(Stellenbosch : Stellenbosch University, 1990-12)ENGLISH ABSTRACT: Catalase was extracted and isolated from BCG bacilli by the following precedures : sonication, treatment with deoxyribonuclease, treatment with octyl glucoside and sonification, ammonium sulphate ... -
LC-MS/MS methods for the quantification of sulfasalazine and sulfapyridine in various matrices: application to a pharmacokinetic study
(Stellenbosch : Stellenbosch University, 2022-11)ENGLISH ABSTRACT: Introduction: An early phase clinical trial which took place at The Mercy Hospital for Women in Australia assessed the use of sulfasalazine as a treatment for preterm pre-eclampsia. This project consisted ... -
Neurological risk of prolonged low dose exposure to imidacloprid in zebrafish
(Stellenbosch : Stellenbosch University, 2022-11)ENGLISH ABSTRACT: Imidacloprid (IMI) is a systemic neonicotinoid insecticide intended to replace the organophosphate pesticides in agriculture. Extensive use of these pesticides increases the risk to the environment and ... -
Pharmacokinetic study of anti-tb drug para-aminosalicylic acid and its metabolites: a possible relationship with the development of toxicity
(Stellenbosch : Stellenbosch University, 2019-04)Background Para-aminosalicylic acid (PAS) is a bacteriostatic anti-tuberculosis (anti-TB) drug, used in the treatment of multi-drug resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB). While PAS has ... -
Pharmacokinetics and dosing rationale of Para-Aminosalicylic acid in children and the evaluation of the in vitro metabolism of Ethionamide, Terizidone and Para-aminosalicylic acid
(Stellenbosch : Stellenbosch University, 2012-03)ENGLISH ABSTRACT: BACKGROUND: The emergence of mycobacterium tuberculosis resistance to first line drugs has renewed interest in second-line anti-tuberculosis drugs. Generally, Paraaminosalicylic acid (PAS) is less ... -
Pharmacokinetics of twice-daily versus once-daily dosing with granular slow-release para-aminosalicylic acid in adults on second-line anti-tuberculosis and antiretroviral treatment
(Stellenbosch : Stellenbosch University, 2013-12)ENGLISH ABSTRACT: Background: Para-aminosalicylic acid (PAS) is one of the first effective anti-tuberculosis agents and has become one of the principal second-line drugs to treat patients with an extended resistance spectrum. ... -
The role of Phosphodiesterase (PDE3) in heart protection.
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: Introduction: During a heart attack the blood supply to the heart is reduced significantly, known as ischemia (Reimer & Jennings, 1991). Energy generating pathways that require oxygen become inhibited in ... -
The role of surfactant in, and a comparison of, the permeability of porcine and human epithelia to various chemical compounds
(Stellenbosch : University of Stellenbosch, 2005-12)In this thesis, research results are reported on the role of natural and synthetic surfactants on the in vitro permeability characteristics of various chemical compounds across porcine (buccal, bronchial, arterial, venous ... -
The specific binding of the thyroid hormones to matrix isolated from rat liver nuclei
(Health & Medical Publishing Group, 1982)Specific binding sites for the thyroid hormones have been demonstrated in the liver nuclear matrix, a structural framework of the nucleus. When labelled 3,5,3'-tri-iodo-L-thyronine ([125I]T3) is injected into rats, 5% of ... -
Using STORM and TIRF in tandem to investigate adherence and migration patterns in stem cells
(Stellenbosch : Stellenbosch University, 2021-03)Background: Cell migration is a dynamic process in physiology requiring pseudopodia, elongated cell protrusions, to associate with the extracellular matrix (ECM) and propel cells forward. The interaction is established ... -
Venomous spider bites in south africa: epidemiology and clinical features
(Stellenbosch : Stellenbosch University, 2019-04)Introduction: Worldwide the number of spider bite calls to poison centres comprises less than 2.5% of calls. Only a small proportion of spiders cause serious envenomation in humans. The known medically important spiders ... -
A zebrafish larval model for drug-induced hepatic Injury due to first-line antituberculosis drugs and possible prevention/treatment with N-acetyl-cysteine
(Stellenbosch : Stellenbosch University, 2022-11)ENGLISH ABSTRACT: Background Tuberculosis (TB) is ranked as the second most deadly infectious disease worldwide. First-line TB medication is associated with the development of drug-induced liver injury (DILI). The ...
