Browsing Masters Degrees (Clinical Pharmacology) by Title
Now showing items 7-26 of 28
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A cross-sectional study to investigate the knowledge, attitudes, and current practices of pharmacovigilance, among medical doctors and pharmacists in South Africa
(Stellenbosch : Stellenbosch University, 2021-12)Background: Pharmacovigilance pertains to activities aimed at monitoring medicines for related safety concerns, thereby ensuring patient safety and wellbeing. The primary method of pharmacovigilance is spontaneous reporting ... -
A descriptive study to determine the prevalence of TPMT polymorphism in Healthy male subjects in Central South Africa
(Stellenbosch : Stellenbosch University, 2014-03)ENGLISH SUMMARY : Thiopurine medications e.g. Azathioprine and 6-Mercaptopurine are metabolized by the thiopurine methyltransferase (TPMT) enzyme. This enzyme activity is highly variable due to polymorphism of the TPMT ... -
Development of a LC-MS/MS method for the detection of snake venom toxins in human plasma
(Stellenbosch : Stellenbosch University, 2022-12)ENGLISH ABSTRACT: Background: Snakebite envenomation in sub-Saharan Africa significantly threatens human health. Species that was responsible for the envenomation are rarely positively identified. There are no rapid ... -
Development of LC-MS/MS toxicology screening methods for common poisoning agents in South Africa
(Stellenbosch : Stellenbosch University, 2020-12)ENGLISH ABSTRACT: Background: Hospitals admit many patients suffering from acute poisoning on a regular basis. Over a single year period the Tygerberg Poison Information Centre (TPIC) dealt with 4 771 consultations related ... -
Drug-drug interactions between antiretrovirals and fluconazole in HIV-infected patients
(Stellenbosch : Stellenbosch University, 2012-03)ENGLISH ABSTRACT: Background: HIV-positive patients have a significantly weakened immune system which makes them highly susceptible for opportunistic infections, requiring additional treatment. Cryptococcal meningitis ... -
The effect of dolutegravir on adipose tissue health
(Stellenbosch : Stellenbosch University, 2022-10)ENGLISH ABSTRACT: Introduction: Dolutegravir, an integrase strand transfer inhibitor (INSTI), forms part of the first-line antiretroviral (ARV) therapy. Despite low cost, fewer drug-drug interactions and minimal reported ... -
The effect of Dolutegravir on redox and vascular integrity
(Stellenbosch : Stellenbosch University, 2022-10)ENGLISH ABSTRACT: Background: Of the estimated 7.2 million people living with HIV (PLWH) in South Africa, more than 50% are on antiretroviral (ARV) medication. Dolutegravir (DTG), an integrase strand transfer inhibitor ... -
Effect of ultrasound on transdermal permeation of diclofenac and the temperature effects on human skin
(Stellenbosch : University of Stellenbosch, 2005-12)During the last two decades the effects of ultrasound on the transdermal diffusion of a wide variety of drugs have been extensively investigated. Because there is much uncertainty regarding the efficacy of and mechanisms ... -
Exploring and identifying the indigenous healers of madwaleni and their relationship with ethnobotany and healthcare
(Stellenbosch : Stellenbosch University, 2019-04)Rationale: The use of indigenous medicine is widely known in South Africa. In fact, it is estimated that 80-85% of black South Africans consult with indigenous healers in both rural and urban communities (Moshabela, et ... -
Inhibitory effect of selected herbal supplements on CYP450-mediated metabolism : an in vitro approach
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: INTRODUCTION Herbal products are popularly used as complementary and alternative medicines to treat a variety of conditions. Often patients use them in conjunction with conventional medicines. Herbal ... -
Karakterisering van die katalase van BCG : invloed van isoniasied op die gesuiwerde ensiem
(Stellenbosch : Stellenbosch University, 1990-12)ENGLISH ABSTRACT: Catalase was extracted and isolated from BCG bacilli by the following precedures : sonication, treatment with deoxyribonuclease, treatment with octyl glucoside and sonification, ammonium sulphate ... -
LC-MS/MS methods for the quantification of sulfasalazine and sulfapyridine in various matrices: application to a pharmacokinetic study
(Stellenbosch : Stellenbosch University, 2022-11)ENGLISH ABSTRACT: Introduction: An early phase clinical trial which took place at The Mercy Hospital for Women in Australia assessed the use of sulfasalazine as a treatment for preterm pre-eclampsia. This project consisted ... -
Neurological risk of prolonged low dose exposure to imidacloprid in zebrafish
(Stellenbosch : Stellenbosch University, 2022-11)ENGLISH ABSTRACT: Imidacloprid (IMI) is a systemic neonicotinoid insecticide intended to replace the organophosphate pesticides in agriculture. Extensive use of these pesticides increases the risk to the environment and ... -
Pharmacokinetic study of anti-tb drug para-aminosalicylic acid and its metabolites: a possible relationship with the development of toxicity
(Stellenbosch : Stellenbosch University, 2019-04)Background Para-aminosalicylic acid (PAS) is a bacteriostatic anti-tuberculosis (anti-TB) drug, used in the treatment of multi-drug resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB). While PAS has ... -
Pharmacokinetics and dosing rationale of Para-Aminosalicylic acid in children and the evaluation of the in vitro metabolism of Ethionamide, Terizidone and Para-aminosalicylic acid
(Stellenbosch : Stellenbosch University, 2012-03)ENGLISH ABSTRACT: BACKGROUND: The emergence of mycobacterium tuberculosis resistance to first line drugs has renewed interest in second-line anti-tuberculosis drugs. Generally, Paraaminosalicylic acid (PAS) is less ... -
Pharmacokinetics of twice-daily versus once-daily dosing with granular slow-release para-aminosalicylic acid in adults on second-line anti-tuberculosis and antiretroviral treatment
(Stellenbosch : Stellenbosch University, 2013-12)ENGLISH ABSTRACT: Background: Para-aminosalicylic acid (PAS) is one of the first effective anti-tuberculosis agents and has become one of the principal second-line drugs to treat patients with an extended resistance spectrum. ... -
The role of Phosphodiesterase (PDE3) in heart protection.
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: Introduction: During a heart attack the blood supply to the heart is reduced significantly, known as ischemia (Reimer & Jennings, 1991). Energy generating pathways that require oxygen become inhibited in ... -
The role of surfactant in, and a comparison of, the permeability of porcine and human epithelia to various chemical compounds
(Stellenbosch : University of Stellenbosch, 2005-12)In this thesis, research results are reported on the role of natural and synthetic surfactants on the in vitro permeability characteristics of various chemical compounds across porcine (buccal, bronchial, arterial, venous ... -
The specific binding of the thyroid hormones to matrix isolated from rat liver nuclei
(Health & Medical Publishing Group, 1982)Specific binding sites for the thyroid hormones have been demonstrated in the liver nuclear matrix, a structural framework of the nucleus. When labelled 3,5,3'-tri-iodo-L-thyronine ([125I]T3) is injected into rats, 5% of ... -
Using STORM and TIRF in tandem to investigate adherence and migration patterns in stem cells
(Stellenbosch : Stellenbosch University, 2021-03)Background: Cell migration is a dynamic process in physiology requiring pseudopodia, elongated cell protrusions, to associate with the extracellular matrix (ECM) and propel cells forward. The interaction is established ...
