Browsing Masters Degrees (Anatomical Pathology) by Title
Now showing items 1-17 of 17
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Analysis of hereditary haemochromatosis and clinical correlations in the elderly
(Stellenbosch : Stellenbosch University, 2000-12)ENGLISH ABSTRACT: Hereditary haemochromatosis (HH) is an autosomal recessive iron storage disease where the accumulation of iron in parenchymal organs may lead to diabetes, heart failure, liver cirrhosis, arthropathy, ... -
Automated sputum screening using the BD FocalPointTM Slide Profiler : correlation with transbronchial and transthoracic needle aspirates in a high risk population
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: Background: Sputum is a non-invasive, economic investigation whereby bronchogenic carcinoma can be identified. Manual cytological screening is labour intensive, time-consuming and requires a continuous ... -
Chemotherapy naive breast cancer: a correlation study between BD Cytorich™ Red cell blocks and formalin- fixed paraffinembedded tissue blocks
(Stellenbosch : Stellenbosch University, 2019-04)Background: The ever increasing burden of breast cancer, the most common cancer among women, demands a diagnostic test that is rapid, reliable, informative and cost-effective; particularly in countries with limited ... -
Comparison of Xpert® Breast cancer STRAT4 assay and immunohistochemistry for the evaluation of breast cancer biomarkers in South African patients
(Stellenbosch : Stellenbosch University, 2020-12)Background: Breast cancer is one of the most common cancers diagnosed in women and approximately 60% of breast cancer related deaths are reported in low-and middle-income countries. Breast cancer ... -
The contribution of the placenta to the diagnosis of congenital tuberculosis
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: The aim of this pilot project was to determine whether mothers with laboratory confirmed or clinically suspected tuberculosis (TB) had evidence of TB in the placenta. A secondary objective was to ... -
Determining the suitability of bio-specimens obtained by fine needle aspiration biopsy at a tertiary hospital in Malawi for immunocytochemical assessment
(Stellenbosch : Stellenbosch University, 2022-04)ENGLISH SUMMARY: Fine-needle aspiration biopsy (FNAB) is a quick, economical, least invasive and easy to perform a minor surgical procedure. In resource-limited settings, FNAB is of utmost importance in providing a ... -
Development of a novel pre-screen algorithm for cardio-metabolic risk management using a genomics database resource
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: The timely assessment and treatment of dyslipidaemia is an important component of cardiovascular risk screening and intervention. The apolipoprotein E (APOE) ε-2/ε-3/ε-4 polymorphism associated with ... -
Evaluating the role of long-term urine bio-banking on the stability of urine bio-markers in the diagnosis of pre-eclampsia
(Stellenbosch : Stellenbosch University, 2019-04)ENGLISH ABSTRACT: The aim of the pre-eclampsia (PE) and eclampsia monitoring, prevention and treatment consortium is to develop a rapid diagnostic test for PE in pregnant women because early identification of PE would ... -
Evaluation of high-throughput methodology for multi-gene screening in patients with Non-Alcoholic Fatty Liver Disease (NAFLD)
(Stellenbosch : Stellenbosch University, 2011-12)ENGLISH ABSTRACT: Non-Alcoholic Fatty Liver Disease (NAFLD) is the most prevalent chronic liver disease in Western countries and is considered the hepatic manifestation of the Metabolic Syndrome (MetS). Its heterogeneous ... -
Genetic aspects of pre-eclampsia : mutation screening of the low-density lipoprotein receptor, methylenetetrahydrofolate reductase, prothrombin and factor V candidate genes
(Stellenbosch : Stellenbosch University, 2001-03)ENGLISH ABSTRACT: Pre-eclampsia is a condition unique to pregnancy and primarily affects the maternal and placental vascular endothelium. It has significant morbidity and mortality consequences for both mother and infant. ... -
HPV strain prevalence and HPV-related biomarker expression in vulvar carcinoma at Tygerberg academic hospital.
(Stellenbosch : Stellenbosch University, 2019-12)ENGLISH ABSTRACT: The incidence of vulvar carcinoma in younger women has increased, possibly due to augmented human papillomavirus (HPV) infection. Variable geographic prevalence of HPV that are associated with vulvar ... -
Investigation and management of primary immunodeficiency in South African children
(Health and Medical Publishing Group, 2014)ENGLISH ABSTRACT: The primary immunodeficiency diseases (PIDs) are inherited, non-communicable diseases that cause immunological dysfunction. PIDs are seldom reported in South Africa (SA). Based on a mid-2013 population ... -
The investigation of bronchoalveolar lavage fluid in paediatric chronic wheezers
(Stellenbosch : Stellenbosch University., 2020-03)ENGLISH ABSTRACT: Background: Paediatric broncho-alveolar lavage (BAL) is a minimally invasive procedure, performed during flexible bronchoscopy using isotonic saline to obtain a sample of bronchial and alveolar fluid from ... -
The MED-PED project : presymptomatic diagnosis in families with disease- related LDL receptor gene mutations
(Stellenbosch : Stellenbosch University, 2000-03)ENGLISH ABSTRACT: Familial hypercholesterolaemia (FH) contributes significantly to the high death rate from cardiovascular disease worldwide. FH is a common autosomal co-dominant disease characterised by raised cholesterol ... -
Molecular-genetic analysis of Hirschsprung's disease in South Africa
(Stellenbosch : Stellenbosch University, 2000-03)ENGLISH ABSTRACT: Hirschsprung's disease, or aganglionic megacolon, is a common cause of intestinal obstruction in neonates and is associated with the congenital absence of intrinsic ganglion cells in the myenteric and ... -
Ontogeny of the innate immune response in healthy South African infants
(Stellenbosch : Stellenbosch University, 2012-12)ENGLISH ABSTRACT: Infection is a major cause of morbidity and mortality in infants within the first few months of life. Susceptibility to infectious disease in this vulnerable population is more prevalent in resource-limited ... -
Prevalence of succinate dehydrogenase deficiency in paragangliomas and pheochromocytomas at Tygerberg Hospital: a retrospective review.
(Stellenbosch : Stellenbosch University, 2020-12)IntroductionPheochromocytomas (PC) and paragangliomas (PGL) are rare neural crest-derived tumours that occur at adrenal and extra-adrenal sites. These tumours may be sporadic but a significant proportion are caused by ...
